158 related articles for article (PubMed ID: 34429853)
1. Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors.
Gallego-Yerga L; Ochoa R; Lans I; Peña-Varas C; Alegría-Arcos M; Cossio P; Ramírez D; Peláez R
Comput Struct Biotechnol J; 2021; 19():4360-4372. PubMed ID: 34429853
[TBL] [Abstract][Full Text] [Related]
2. Identification of Essential 2D and 3D Chemical Features for Discovery of the Novel Tubulin Polymerization Inhibitors.
Azimi F; Ghasemi JB; Saghaei L; Hassanzadeh F; Mahdavi M; Sadeghi-Aliabadi H; Scotti MT; Scotti L
Curr Top Med Chem; 2019; 19(13):1092-1120. PubMed ID: 31109275
[TBL] [Abstract][Full Text] [Related]
3. Ligand- and structural-based discovery of potential small molecules that target the colchicine site of tubulin for cancer treatment.
Guo Q; Zhang H; Deng Y; Zhai S; Jiang Z; Zhu D; Wang L
Eur J Med Chem; 2020 Jun; 196():112328. PubMed ID: 32320841
[TBL] [Abstract][Full Text] [Related]
4. Structural Investigation of Vinca Domain Tubulin Binders by Pharmacophore, Atom based QSAR, Docking and Molecular Dynamics Simulations.
Athar M; Lone MY; Khedkar VM; Radadiya A; Shah A; Jha PC
Comb Chem High Throughput Screen; 2017; 20(8):682-695. PubMed ID: 28486912
[TBL] [Abstract][Full Text] [Related]
5. Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.
Wang Y; Zhang H; Gigant B; Yu Y; Wu Y; Chen X; Lai Q; Yang Z; Chen Q; Yang J
FEBS J; 2016 Jan; 283(1):102-11. PubMed ID: 26462166
[TBL] [Abstract][Full Text] [Related]
6. Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin.
Kim DY; Kim KH; Kim ND; Lee KY; Han CK; Yoon JH; Moon SK; Lee SS; Seong BL
J Med Chem; 2006 Sep; 49(19):5664-70. PubMed ID: 16970393
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers.
Subba Rao AV; Swapna K; Shaik SP; Lakshma Nayak V; Srinivasa Reddy T; Sunkari S; Shaik TB; Bagul C; Kamal A
Bioorg Med Chem; 2017 Feb; 25(3):977-999. PubMed ID: 28034647
[TBL] [Abstract][Full Text] [Related]
8. Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site.
Li DD; Qin YJ; Zhang X; Yin Y; Zhu HL; Zhao LG
Chem Biol Drug Des; 2015 Oct; 86(4):731-45. PubMed ID: 25711282
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
Lai Q; Wang Y; Wang R; Lai W; Tang L; Tao Y; Liu Y; Zhang R; Huang L; Xiang H; Zeng S; Gou L; Chen H; Yao Y; Yang J
Eur J Med Chem; 2018 Aug; 156():162-179. PubMed ID: 30006162
[TBL] [Abstract][Full Text] [Related]
10. Identification of novel antitubulin agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin colchi-site.
Massarotti A; Theeramunkong S; Mesenzani O; Caldarelli A; Genazzani AA; Tron GC
Chem Biol Drug Des; 2011 Dec; 78(6):913-22. PubMed ID: 22039890
[TBL] [Abstract][Full Text] [Related]
11. Discovery of novel tubulin inhibitors via structure-based hierarchical virtual screening.
Cao R; Liu M; Yin M; Liu Q; Wang Y; Huang N
J Chem Inf Model; 2012 Oct; 52(10):2730-40. PubMed ID: 22992059
[TBL] [Abstract][Full Text] [Related]
12. Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents.
Gallego-Yerga L; Ceña V; Peláez R
Pharmaceutics; 2023 Jun; 15(6):. PubMed ID: 37376146
[TBL] [Abstract][Full Text] [Related]
13. New ligands of the tubulin colchicine site based on X-ray structures.
Álvarez R; Medarde M; Peláez R
Curr Top Med Chem; 2014; 14(20):2231-52. PubMed ID: 25434358
[TBL] [Abstract][Full Text] [Related]
14. Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.
Mangiatordi GF; Trisciuzzi D; Alberga D; Denora N; Iacobazzi RM; Gadaleta D; Catto M; Nicolotti O
Eur J Med Chem; 2017 Oct; 139():792-803. PubMed ID: 28863359
[TBL] [Abstract][Full Text] [Related]
15. Tubulin inhibitor identification by bioactive conformation alignment pharmacophore-guided virtual screening.
Nagarajan S; Choi MJ; Cho YS; Min SJ; Keum G; Kim SJ; Lee CS; Pae AN
Chem Biol Drug Des; 2015 Nov; 86(5):998-1016. PubMed ID: 25845798
[TBL] [Abstract][Full Text] [Related]
16. Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.
Álvarez R; Aramburu L; Gajate C; Vicente-Blázquez A; Mollinedo F; Medarde M; Peláez R
Bioorg Chem; 2020 May; 98():103755. PubMed ID: 32200330
[TBL] [Abstract][Full Text] [Related]
17. Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.
Sharma A; Sáez-Calvo G; Olieric N; de Asís Balaguer F; Barasoain I; Lamberth C; Díaz JF; Steinmetz MO
Int J Mol Sci; 2017 Jun; 18(7):. PubMed ID: 28640209
[TBL] [Abstract][Full Text] [Related]
18. The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo.
Cui YJ; Ma CC; Zhang CM; Tang LQ; Liu ZP
Eur J Med Chem; 2020 Feb; 187():111968. PubMed ID: 31865012
[TBL] [Abstract][Full Text] [Related]
19. Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.
Maklad RM; AbdelHafez EMN; Abdelhamid D; Aly OM
Bioorg Chem; 2020 Jun; 99():103767. PubMed ID: 32325332
[TBL] [Abstract][Full Text] [Related]
20. Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents.
Kim ND; Park ES; Kim YH; Moon SK; Lee SS; Ahn SK; Yu DY; No KT; Kim KH
Bioorg Med Chem; 2010 Oct; 18(19):7092-100. PubMed ID: 20810285
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
