191 related articles for article (PubMed ID: 34450570)
1. Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2.
Wei D; Hu T; Zhang Y; Zheng W; Xue H; Shen J; Xie Y; Aisa HA
Bioorg Med Chem; 2021 Sep; 46():116364. PubMed ID: 34450570
[TBL] [Abstract][Full Text] [Related]
2. Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets.
Cox RM; Wolf JD; Lieber CM; Sourimant J; Lin MJ; Babusis D; DuPont V; Chan J; Barrett KT; Lye D; Kalla R; Chun K; Mackman RL; Ye C; Cihlar T; Martinez-Sobrido L; Greninger AL; Bilello JP; Plemper RK
Nat Commun; 2021 Nov; 12(1):6415. PubMed ID: 34741049
[TBL] [Abstract][Full Text] [Related]
3. Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys.
Mackman RL; Kalla RV; Babusis D; Pitts J; Barrett KT; Chun K; Du Pont V; Rodriguez L; Moshiri J; Xu Y; Lee M; Lee G; Bleier B; Nguyen AQ; O'Keefe BM; Ambrosi A; Cook M; Yu J; Dempah KE; Bunyan E; Riola NC; Lu X; Liu R; Davie A; Hsiang TY; Dearing J; Vermillion M; Gale M; Niedziela-Majka A; Feng JY; Hedskog C; Bilello JP; Subramanian R; Cihlar T
J Med Chem; 2023 Sep; 66(17):11701-11717. PubMed ID: 37596939
[TBL] [Abstract][Full Text] [Related]
4. Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
Schäfer A; Martinez DR; Won JJ; Meganck RM; Moreira FR; Brown AJ; Gully KL; Zweigart MR; Conrad WS; May SR; Dong S; Kalla R; Chun K; Du Pont V; Babusis D; Tang J; Murakami E; Subramanian R; Barrett KT; Bleier BJ; Bannister R; Feng JY; Bilello JP; Cihlar T; Mackman RL; Montgomery SA; Baric RS; Sheahan TP
Sci Transl Med; 2022 May; 14(643):eabm3410. PubMed ID: 35315683
[TBL] [Abstract][Full Text] [Related]
5. The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants.
Cao L; Li Y; Yang S; Li G; Zhou Q; Sun J; Xu T; Yang Y; Liao R; Shi Y; Yang Y; Zhu T; Huang S; Ji Y; Cong F; Luo Y; Zhu Y; Luan H; Zhang H; Chen J; Liu X; Luo R; Liu L; Wang P; Yu Y; Xing F; Ke B; Zheng H; Deng X; Zhang W; Lin C; Shi M; Li CM; Zhang Y; Zhang L; Dai J; Lu H; Zhao J; Zhang X; Guo D
Sci Transl Med; 2022 Sep; 14(661):eabm7621. PubMed ID: 35579533
[TBL] [Abstract][Full Text] [Related]
6. The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
Martinez DR; Moreira FR; Catanzaro NJ; Diefenbacher MV; Zweigart MR; Gully KL; De la Cruz G; Brown AJ; Adams LE; Yount B; Baric TJ; Mallory ML; Conrad H; May SR; Dong S; Scobey DT; Nguyen C; Montgomery SA; Perry JK; Babusis D; Barrett KT; Nguyen AH; Nguyen AQ; Kalla R; Bannister R; Feng JY; Cihlar T; Baric RS; Mackman RL; Bilello JP; Schäfer A; Sheahan TP
Sci Transl Med; 2024 May; 16(748):eadj4504. PubMed ID: 38776389
[TBL] [Abstract][Full Text] [Related]
7. Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs.
Schooley RT; Carlin AF; Beadle JR; Valiaeva N; Zhang XQ; Clark AE; McMillan RE; Leibel SL; McVicar RN; Xie J; Garretson AF; Smith VI; Murphy J; Hostetler KY
Antimicrob Agents Chemother; 2021 Sep; 65(10):e0115521. PubMed ID: 34310217
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of dengue virus by an ester prodrug of an adenosine analog.
Chen YL; Yin Z; Lakshminarayana SB; Qing M; Schul W; Duraiswamy J; Kondreddi RR; Goh A; Xu HY; Yip A; Liu B; Weaver M; Dartois V; Keller TH; Shi PY
Antimicrob Agents Chemother; 2010 Aug; 54(8):3255-61. PubMed ID: 20516277
[TBL] [Abstract][Full Text] [Related]
9. AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2
Good SS; Westover J; Jung KH; Zhou XJ; Moussa A; La Colla P; Collu G; Canard B; Sommadossi JP
Antimicrob Agents Chemother; 2021 Mar; 65(4):. PubMed ID: 33558299
[TBL] [Abstract][Full Text] [Related]
10. Broad-Spectrum
Lo MK; Shrivastava-Ranjan P; Chatterjee P; Flint M; Beadle JR; Valiaeva N; Murphy J; Schooley RT; Hostetler KY; Montgomery JM; Spiropoulou CF
Microbiol Spectr; 2021 Dec; 9(3):e0153721. PubMed ID: 34817209
[TBL] [Abstract][Full Text] [Related]
11. Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19.
Rasmussen HB; Jürgens G; Thomsen R; Taboureau O; Zeth K; Hansen PE; Hansen PR
Viruses; 2021 Jul; 13(7):. PubMed ID: 34372575
[TBL] [Abstract][Full Text] [Related]
12. Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models.
Li Y; Cao L; Li G; Cong F; Li Y; Sun J; Luo Y; Chen G; Li G; Wang P; Xing F; Ji Y; Zhao J; Zhang Y; Guo D; Zhang X
J Med Chem; 2022 Feb; 65(4):2785-2793. PubMed ID: 33523654
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(
Abuduaini T; Roy V; Marlet J; Gaudy-Graffin C; Brand D; Baronti C; Touret F; Coutard B; McBrayer TR; Schinazi RF; Agrofoglio LA
Molecules; 2021 Mar; 26(5):. PubMed ID: 33803417
[TBL] [Abstract][Full Text] [Related]
14. Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions.
Deb S; Reeves AA
J Pharm Pharm Sci; 2021; 24():277-291. PubMed ID: 34107241
[TBL] [Abstract][Full Text] [Related]
15. Repurposing Nucleoside Analogs for Human Coronaviruses.
Zandi K; Amblard F; Musall K; Downs-Bowen J; Kleinbard R; Oo A; Cao D; Liang B; Russell OO; McBrayer T; Bassit L; Kim B; Schinazi RF
Antimicrob Agents Chemother; 2020 Dec; 65(1):. PubMed ID: 33122172
[TBL] [Abstract][Full Text] [Related]
16. In vitro activity of itraconazole against SARS-CoV-2.
Van Damme E; De Meyer S; Bojkova D; Ciesek S; Cinatl J; De Jonghe S; Jochmans D; Leyssen P; Buyck C; Neyts J; Van Loock M
J Med Virol; 2021 Jul; 93(7):4454-4460. PubMed ID: 33666253
[TBL] [Abstract][Full Text] [Related]
17. Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy.
Li J; Liu S; Shi J; Wang X; Xue Y; Zhu HJ
ACS Pharmacol Transl Sci; 2021 Apr; 4(2):870-887. PubMed ID: 33855276
[TBL] [Abstract][Full Text] [Related]
18. Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection.
Pitts J; Babusis D; Vermillion MS; Subramanian R; Barrett K; Lye D; Ma B; Zhao X; Riola N; Xie X; Kajon A; Lu X; Bannister R; Shi PY; Toteva M; Porter DP; Smith BJ; Cihlar T; Mackman R; Bilello JP
Antiviral Res; 2022 Jul; 203():105329. PubMed ID: 35525335
[TBL] [Abstract][Full Text] [Related]
19. Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.
Murakami E; Wang T; Babusis D; Lepist EI; Sauer D; Park Y; Vela JE; Shih R; Birkus G; Stefanidis D; Kim CU; Cho A; Ray AS
Antimicrob Agents Chemother; 2014; 58(4):1943-51. PubMed ID: 24419340
[TBL] [Abstract][Full Text] [Related]
20. The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract.
Shi Y; Shuai L; Wen Z; Wang C; Yan Y; Jiao Z; Guo F; Fu ZF; Chen H; Bu Z; Peng G
Emerg Microbes Infect; 2021 Dec; 10(1):481-492. PubMed ID: 33691601
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
