191 related articles for article (PubMed ID: 34459410)
1. Characterization of a Knock-In Mouse Model with a Huntingtin Exon 1 Deletion.
Braatz EM; André EA; Liu JP; Zeitlin SO
J Huntingtons Dis; 2021; 10(4):435-454. PubMed ID: 34459410
[TBL] [Abstract][Full Text] [Related]
2. Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.
André EA; Braatz EM; Liu JP; Zeitlin SO
J Huntingtons Dis; 2017; 6(1):47-62. PubMed ID: 28211815
[TBL] [Abstract][Full Text] [Related]
3. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis.
Zheng S; Ghitani N; Blackburn JS; Liu JP; Zeitlin SO
Mol Brain; 2012 Aug; 5():28. PubMed ID: 22892315
[TBL] [Abstract][Full Text] [Related]
4. Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.
Franich NR; Hickey MA; Zhu C; Osborne GF; Ali N; Chu T; Bove NH; Lemesre V; Lerner RP; Zeitlin SO; Howland D; Neueder A; Landles C; Bates GP; Chesselet MF
J Neurosci Res; 2019 Dec; 97(12):1590-1605. PubMed ID: 31282030
[TBL] [Abstract][Full Text] [Related]
5. HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis.
Xu S; Li G; Ye X; Chen D; Chen Z; Xu Z; Daniele M; Tambone S; Ceccacci A; Tomei L; Ye L; Yu Y; Solbach A; Farmer SM; Stimming EF; McAllister G; Marchionini DM; Zhang S
PLoS Genet; 2022 Jul; 18(7):e1010302. PubMed ID: 35853002
[TBL] [Abstract][Full Text] [Related]
6. Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro.
Clabough EB; Zeitlin SO
Hum Mol Genet; 2006 Feb; 15(4):607-23. PubMed ID: 16403806
[TBL] [Abstract][Full Text] [Related]
7. Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form.
Yang H; Yang S; Jing L; Huang L; Chen L; Zhao X; Yang W; Pan Y; Yin P; Qin ZS; Tang B; Li S; Li XJ
Nat Commun; 2020 May; 11(1):2582. PubMed ID: 32444599
[TBL] [Abstract][Full Text] [Related]
8. Is Huntingtin Dispensable in the Adult Brain?
Liu JP; Zeitlin SO
J Huntingtons Dis; 2017; 6(1):1-17. PubMed ID: 28339401
[TBL] [Abstract][Full Text] [Related]
9. Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.
Franich NR; Basso M; André EA; Ochaba J; Kumar A; Thein S; Fote G; Kachemov M; Lau AL; Yeung SY; Osmand A; Zeitlin SO; Ratan RR; Thompson LM; Steffan JS
J Huntingtons Dis; 2018; 7(2):137-150. PubMed ID: 29843246
[TBL] [Abstract][Full Text] [Related]
10. Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice.
Neveklovska M; Clabough EB; Steffan JS; Zeitlin SO
J Huntingtons Dis; 2012; 1(1):71-87. PubMed ID: 22956985
[TBL] [Abstract][Full Text] [Related]
11. N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.
Liu X; Wang CE; Hong Y; Zhao T; Wang G; Gaertig MA; Sun M; Li S; Li XJ
PLoS Genet; 2016 May; 12(5):e1006083. PubMed ID: 27203582
[TBL] [Abstract][Full Text] [Related]
12. Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective.
Baias M; Smith PE; Shen K; Joachimiak LA; Żerko S; Koźmiński W; Frydman J; Frydman L
J Am Chem Soc; 2017 Jan; 139(3):1168-1176. PubMed ID: 28085263
[TBL] [Abstract][Full Text] [Related]
13. Huntingtin's N-Terminus Rearrangements in the Presence of Membranes: A Joint Spectroscopic and Computational Perspective.
Levy GR; Shen K; Gavrilov Y; Smith PES; Levy Y; Chan R; Frydman J; Frydman L
ACS Chem Neurosci; 2019 Jan; 10(1):472-481. PubMed ID: 30149694
[TBL] [Abstract][Full Text] [Related]
14. Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice.
Zhao X; Sun Y; Wang Z; Chen L; Li S; Li XJ
Front Cell Neurosci; 2022; 16():1021592. PubMed ID: 36439204
[TBL] [Abstract][Full Text] [Related]
15. Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt
McAdam RL; Morton A; Gordon SL; Alterman JF; Khvorova A; Cousin MA; Smillie KJ
Neurobiol Dis; 2020 Feb; 134():104637. PubMed ID: 31614197
[TBL] [Abstract][Full Text] [Related]
16. Polyglutamine tracts regulate beclin 1-dependent autophagy.
Ashkenazi A; Bento CF; Ricketts T; Vicinanza M; Siddiqi F; Pavel M; Squitieri F; Hardenberg MC; Imarisio S; Menzies FM; Rubinsztein DC
Nature; 2017 May; 545(7652):108-111. PubMed ID: 28445460
[TBL] [Abstract][Full Text] [Related]
17. In vivo proof-of-concept of removal of the huntingtin caspase cleavage motif-encoding exon 12 approach in the YAC128 mouse model of Huntington's disease.
Casaca-Carreira J; Toonen LJA; Evers MM; Jahanshahi A; van-Roon-Mom WMC; Temel Y
Biomed Pharmacother; 2016 Dec; 84():93-96. PubMed ID: 27639545
[TBL] [Abstract][Full Text] [Related]
18. SUMOylation Prevents Huntingtin Fibrillization and Localization onto Lipid Membranes.
Sedighi F; Adegbuyiro A; Legleiter J
ACS Chem Neurosci; 2020 Feb; 11(3):328-343. PubMed ID: 31880908
[TBL] [Abstract][Full Text] [Related]
19. The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
Wong YC; Holzbaur EL
J Neurosci; 2014 Jan; 34(4):1293-305. PubMed ID: 24453320
[TBL] [Abstract][Full Text] [Related]
20. Interaction between huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins.
Zhang H; Wu S; Itzhaki LS; Perrett S
Protein Sci; 2023 Dec; 32(12):e4810. PubMed ID: 37853955
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
