These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

111 related articles for article (PubMed ID: 3449089)

  • 1. Conformational analysis of lipophilic antifolates: crystal and molecular structures of three s-triazine dihydrofolate reductase inhibitors.
    Cody V; Sutton PA
    Anticancer Drug Des; 1987 Dec; 2(3):253-62. PubMed ID: 3449089
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
    Cody V; Galitsky N; Luft JR; Pangborn W; Queener SF; Gangjee A
    Acta Crystallogr D Biol Crystallogr; 2002 Sep; 58(Pt 9):1393-9. PubMed ID: 12198294
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Computer graphic modeling in drug design--conformational analysis of antifolate binding to avian dihydrofolate reductase: crystal and molecular structures of 2,4-diamino-5-cyclohexyl-6-methylpyrimidine and 5-cyclohexyl-6-methyluracil.
    Cody V; Ciszak E
    Anticancer Drug Des; 1991 May; 6(2):83-93. PubMed ID: 2039584
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystallographic studies of the antineoplastic antifolate 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) ethanesulfonate salt.
    Cody V
    Cancer Biochem Biophys; 1983; 6(3):173-7. PubMed ID: 6850552
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comparison of triazines as inhibitors of L1210 dihydrofolate reductase and of L1210 cells sensitive and resistant to methotrexate.
    Selassie CD; Strong CD; Hansch C; Delcamp TJ; Freisheim JH; Khwaja TA
    Cancer Res; 1986 Feb; 46(2):744-56. PubMed ID: 3940640
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CNDO/2 molecular orbital calculations on the antifolate DAMP and some related species: structural geometries, ring distortions, change distributions and conformational characteristics.
    Welsh WJ; Cody V; Mark JE; Zakrzewski SF
    Cancer Biochem Biophys; 1983 Dec; 7(1):27-38. PubMed ID: 6667452
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis.
    Hathaway BA; Guo ZR; Hansch C; Delcamp TJ; Susten SS; Freisheim JH
    J Med Chem; 1984 Feb; 27(2):144-9. PubMed ID: 6694162
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.
    Cody V; Galitsky N; Luft JR; Pangborn W; Rosowsky A; Blakley RL
    Biochemistry; 1997 Nov; 36(45):13897-903. PubMed ID: 9374868
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A comparison of the inhibition of bovine and murine leukemia dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-X-phenyl)-s-triazines.
    Guo ZR; Dietrich SW; Hansch C; Dolnick BJ; Bertino JR
    Mol Pharmacol; 1981 Nov; 20(3):649-56. PubMed ID: 7329407
    [No Abstract]   [Full Text] [Related]  

  • 10. A molecular shape analysis and quantitative structure-activity relationship investigation of some triazine-antifolate inhibitors of Leishmania dihydrofolate reductase.
    Koehler MG; Rowberg-Schaefer K; Hopfinger AJ
    Arch Biochem Biophys; 1988 Oct; 266(1):152-61. PubMed ID: 3178219
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of the optimal third generation antifolate against P. falciparum and P. vivax.
    Hunt SY; Detering C; Varani G; Jacobus DP; Schiehser GA; Shieh HM; Nevchas I; Terpinski J; Sibley CH
    Mol Biochem Parasitol; 2005 Dec; 144(2):198-205. PubMed ID: 16181688
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.
    Gangjee A; Guo X; Queener SF; Cody V; Galitsky N; Luft JR; Pangborn W
    J Med Chem; 1998 Apr; 41(8):1263-71. PubMed ID: 9548816
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of dihydrofolate reductase. 3. 4.6-Diamino-1,2-dihydro-2,2-dimethyl-1-(2-substituted-phenyl)-s-triazine inhibition of bovine liver and mouse tumor enzymes.
    Kim KH; Dietrich SW; Hansch C; Dolnick BJ; Bertino JR
    J Med Chem; 1980 Nov; 23(11):1248-51. PubMed ID: 7452676
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ab initio studies of 2,4-diamino triazine and its complexes with ligands: a model for inhibitor-active site interactions of dihydrofolate reductase.
    Sapse AM; Waltham MC; Bertino JR
    Cancer Invest; 1994; 12(5):469-76. PubMed ID: 7922702
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
    Jones TR; Varney MD; Webber SE; Lewis KK; Marzoni GP; Palmer CL; Kathardekar V; Welsh KM; Webber S; Matthews DA; Appelt K; Smith WW; Janson CA; Villafranca JE; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Moomaw EW; Bartlett CA; Morse CA
    J Med Chem; 1996 Feb; 39(4):904-17. PubMed ID: 8632414
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
    Selassie CD; Hansch C; Khwaja TA; Dias CB; Pentecost S
    J Med Chem; 1984 Mar; 27(3):347-57. PubMed ID: 6699880
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
    Rosowsky A; Papoulis AT; Queener SF
    J Med Chem; 1997 Oct; 40(22):3694-9. PubMed ID: 9357537
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.
    Hansch C; Hathaway BA; Guo ZR; Selassie CD; Dietrich SW; Blaney JM; Langridge R; Volz KW; Kaufman BT
    J Med Chem; 1984 Feb; 27(2):129-43. PubMed ID: 6420569
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth.
    Booth RG; Selassie CD; Hansch C; Santi DV
    J Med Chem; 1987 Jul; 30(7):1218-24. PubMed ID: 3599028
    [TBL] [Abstract][Full Text] [Related]  

  • 20. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.
    Cody V; Pace J; Chisum K; Rosowsky A
    Proteins; 2006 Dec; 65(4):959-69. PubMed ID: 17019704
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.