226 related articles for article (PubMed ID: 34517222)
1. Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease.
Wang XX; Xie F; Jia CC; Yan N; Zeng YL; Wu JD; Liu ZP
Eur J Med Chem; 2021 Dec; 225():113821. PubMed ID: 34517222
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020).
Li Y; Sang S; Ren W; Pei Y; Bian Y; Chen Y; Sun H
Eur J Med Chem; 2021 Dec; 226():113874. PubMed ID: 34619465
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease.
Tseng HJ; Lin MH; Shiao YJ; Yang YC; Chu JC; Chen CY; Chen YY; Lin TE; Su CJ; Pan SL; Chen LC; Wang CY; Hsu KC; Huang WJ
Eur J Med Chem; 2020 Apr; 192():112193. PubMed ID: 32151835
[TBL] [Abstract][Full Text] [Related]
4. Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.
Leonhardt M; Sellmer A; Krämer OH; Dove S; Elz S; Kraus B; Beyer M; Mahboobi S
Eur J Med Chem; 2018 May; 152():329-357. PubMed ID: 29738953
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction.
Guo Z; Zhang Z; Zhang Y; Wang G; Huang Z; Zhang Q; Li J
Eur J Med Chem; 2021 Jun; 218():113383. PubMed ID: 33799069
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
Xie SS; Liu J; Tang C; Pang C; Li Q; Qin Y; Nong X; Zhang Z; Guo J; Cheng M; Tang W; Liang N; Jiang N
Eur J Med Chem; 2020 Sep; 202():112475. PubMed ID: 32652406
[TBL] [Abstract][Full Text] [Related]
7. Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
Rabal O; Sánchez-Arias JA; Cuadrado-Tejedor M; de Miguel I; Pérez-González M; García-Barroso C; Ugarte A; Estella-Hermoso de Mendoza A; Sáez E; Espelosin M; Ursua S; Haizhong T; Wei W; Musheng X; Garcia-Osta A; Oyarzabal J
Eur J Med Chem; 2018 Apr; 150():506-524. PubMed ID: 29549837
[TBL] [Abstract][Full Text] [Related]
8. Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
Xu A; He F; Zhang X; Li X; Ran Y; Wei C; James Chou C; Zhang R; Wu J
Bioorg Chem; 2020 May; 98():103721. PubMed ID: 32193030
[TBL] [Abstract][Full Text] [Related]
9. Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation.
Song Q; Li Y; Cao Z; Qiang X; Tan Z; Deng Y
Bioorg Chem; 2019 Mar; 84():137-149. PubMed ID: 30500523
[TBL] [Abstract][Full Text] [Related]
10. 5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes.
Lee HY; Fan SJ; Huang FI; Chao HY; Hsu KC; Lin TE; Yeh TK; Lai MJ; Li YH; Huang HL; Yang CR; Liou JP
J Med Chem; 2018 Aug; 61(16):7087-7102. PubMed ID: 30028616
[TBL] [Abstract][Full Text] [Related]
11. Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma.
Kassab SE; Mowafy S; Alserw AM; Seliem JA; El-Naggar SM; Omar NN; Awad MM
J Enzyme Inhib Med Chem; 2019 Dec; 34(1):1062-1077. PubMed ID: 31072216
[TBL] [Abstract][Full Text] [Related]
12. Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease.
Wang XQ; Zhou LY; Tan RX; Liang GP; Fang SX; Li W; Xie M; Wen YH; Wu JQ; Chen YP
Chem Biodivers; 2021 Nov; 18(11):e2100341. PubMed ID: 34510699
[TBL] [Abstract][Full Text] [Related]
13. Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation.
Tian C; Qiang X; Song Q; Cao Z; Ye C; He Y; Deng Y; Zhang L
Bioorg Chem; 2020 Jan; 94():103477. PubMed ID: 31818478
[TBL] [Abstract][Full Text] [Related]
14. The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.
Negmeldin AT; Knoff JR; Pflum MKH
Eur J Med Chem; 2018 Jan; 143():1790-1806. PubMed ID: 29150330
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis and evaluation of novel bivalent β-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Zhao Y; Ye F; Xu J; Liao Q; Chen L; Zhang W; Sun H; Liu W; Feng F; Qu W
Bioorg Med Chem; 2018 Jul; 26(13):3812-3824. PubMed ID: 29960728
[TBL] [Abstract][Full Text] [Related]
16. Re-exploration of tetrahydro-β-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective activities.
Wen W; Hu J; Wang C; Yang R; Zhang Y; Huang B; Qiao T; Wang J; Chen X
Bioorg Med Chem Lett; 2024 Apr; 102():129670. PubMed ID: 38387692
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer's disease.
Liao Q; Li Q; Zhao Y; Jiang P; Yan Y; Sun H; Liu W; Feng F; Qu W
Bioorg Chem; 2020 Jun; 99():103844. PubMed ID: 32325336
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors.
Liang T; Xue J; Yao Z; Ye Y; Yang X; Hou X; Fang H
Eur J Med Chem; 2021 Oct; 221():113526. PubMed ID: 33992929
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors.
Hsu KC; Chu JC; Tseng HJ; Liu CI; Wang HC; Lin TE; Lee HS; Hsin LW; Wang AH; Lin CH; Huang WJ
Eur J Med Chem; 2021 Jul; 219():113419. PubMed ID: 33845233
[TBL] [Abstract][Full Text] [Related]
20. Novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors to suppress tumor metastasis and invasion in vitro and in vivo.
Li Y; Quan J; Song H; Li D; Ma E; Wang Y; Ma C
Bioorg Chem; 2021 Sep; 114():105081. PubMed ID: 34153811
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
