BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 34535048)

  • 1. EGFR binding Fc domain-drug conjugates: stable and highly potent cytotoxic molecules mediate selective cell killing.
    Jäger S; Dickgiesser S; Tonillo J; Hecht S; Kolmar H; Schröter C
    Biol Chem; 2022 Apr; 403(5-6):525-534. PubMed ID: 34535048
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Generation and Biological Evaluation of Fc Antigen Binding Fragment-Drug Conjugates as a Novel Antibody-Based Format for Targeted Drug Delivery.
    Jäger S; Wagner TR; Rasche N; Kolmar H; Hecht S; Schröter C
    Bioconjug Chem; 2021 Aug; 32(8):1699-1710. PubMed ID: 34185508
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates.
    Jackson D; Atkinson J; Guevara CI; Zhang C; Kery V; Moon SJ; Virata C; Yang P; Lowe C; Pinkstaff J; Cho H; Knudsen N; Manibusan A; Tian F; Sun Y; Lu Y; Sellers A; Jia XC; Joseph I; Anand B; Morrison K; Pereira DS; Stover D
    PLoS One; 2014; 9(1):e83865. PubMed ID: 24454709
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Chemical generation of small molecule-based bispecific antibody-drug conjugates for broadening the target scope.
    Yamaguchi A; Anami Y; Ha SYY; Roeder TJ; Xiong W; Lee J; Ueno NT; Zhang N; An Z; Tsuchikama K
    Bioorg Med Chem; 2021 Feb; 32():116013. PubMed ID: 33482584
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Site-Specific Antibody-Drug Conjugates in Triple Variable Domain Fab Format.
    Hwang D; Rader C
    Biomolecules; 2020 May; 10(5):. PubMed ID: 32422893
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.
    Behrens CR; Ha EH; Chinn LL; Bowers S; Probst G; Fitch-Bruhns M; Monteon J; Valdiosera A; Bermudez A; Liao-Chan S; Wong T; Melnick J; Theunissen JW; Flory MR; Houser D; Venstrom K; Levashova Z; Sauer P; Migone TS; van der Horst EH; Halcomb RL; Jackson DY
    Mol Pharm; 2015 Nov; 12(11):3986-98. PubMed ID: 26393951
    [TBL] [Abstract][Full Text] [Related]  

  • 7. High turnover of tissue factor enables efficient intracellular delivery of antibody-drug conjugates.
    de Goeij BE; Satijn D; Freitag CM; Wubbolts R; Bleeker WK; Khasanov A; Zhu T; Chen G; Miao D; van Berkel PH; Parren PW
    Mol Cancer Ther; 2015 May; 14(5):1130-40. PubMed ID: 25724665
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload.
    Wang Y; Fan S; Zhong W; Zhou X; Li S
    Int J Mol Sci; 2017 Aug; 18(9):. PubMed ID: 28841157
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bivalent EGFR-Targeting DARPin-MMAE Conjugates.
    Karsten L; Janson N; Le Joncour V; Alam S; Müller B; Tanjore Ramanathan J; Laakkonen P; Sewald N; Müller KM
    Int J Mol Sci; 2022 Feb; 23(5):. PubMed ID: 35269611
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells.
    Poźniak M; Porębska N; Krzyścik MA; Sokołowska-Wędzina A; Jastrzębski K; Sochacka M; Szymczyk J; Zakrzewska M; Otlewski J; Opaliński Ł
    Mol Med; 2021 May; 27(1):46. PubMed ID: 33962559
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates.
    Sun X; Ponte JF; Yoder NC; Laleau R; Coccia J; Lanieri L; Qiu Q; Wu R; Hong E; Bogalhas M; Wang L; Dong L; Setiady Y; Maloney EK; Ab O; Zhang X; Pinkas J; Keating TA; Chari R; Erickson HK; Lambert JM
    Bioconjug Chem; 2017 May; 28(5):1371-1381. PubMed ID: 28388844
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F.
    Woitok M; Klose D; Niesen J; Richter W; Abbas M; Stein C; Fendel R; Bialon M; Püttmann C; Fischer R; Barth S; Kolberg K
    Cancer Lett; 2016 Oct; 381(2):323-30. PubMed ID: 27502168
    [TBL] [Abstract][Full Text] [Related]  

  • 13. EpCAM- and EGFR-Specific Antibody Drug Conjugates for Triple-Negative Breast Cancer Treatment.
    Zhang C; Sheng W; Al-Rawe M; Mohiuddin TM; Niebert M; Zeppernick F; Meihold-Heerlein I; Hussain AF
    Int J Mol Sci; 2022 May; 23(11):. PubMed ID: 35682800
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Altering Antibody-Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability.
    Hamblett KJ; Le T; Rock BM; Rock DA; Siu S; Huard JN; Conner KP; Milburn RR; O'Neill JW; Tometsko ME; Fanslow WC
    Mol Pharm; 2016 Jul; 13(7):2387-96. PubMed ID: 27248573
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Antibody drug conjugates, targeting cancer-expressed EGFR, exhibit potent and specific antitumor activity.
    Ho ECH; Qiu R; Miller E; Bilotta MT; FitzGerald D; Antignani A
    Biomed Pharmacother; 2023 Jan; 157():114047. PubMed ID: 36459711
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
    White JB; Fleming R; Masterson L; Ruddle BT; Zhong H; Fazenbaker C; Strout P; Rosenthal K; Reed M; Muniz-Medina V; Howard P; Dixit R; Wu H; Hinrichs MJ; Gao C; Dimasi N
    MAbs; 2019 Apr; 11(3):500-515. PubMed ID: 30835621
    [TBL] [Abstract][Full Text] [Related]  

  • 17. EGFR-targeted humanized single chain antibody fragment functionalized silica nanoparticles for precision therapy of cancer.
    Wu H; Ding X; Chen Y; Cai Y; Yang Z; Jin J
    Int J Biol Macromol; 2023 Dec; 253(Pt 8):127538. PubMed ID: 37866562
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In vivo and in vitro activity of an immunoglobulin Fc fragment (Fcab) with engineered Her-2/neu binding sites.
    Woisetschläger M; Antes B; Borrowdale R; Wiederkum S; Kainer M; Steinkellner H; Wozniak-Knopp G; Moulder K; Rüker F; Mudde GC
    Biotechnol J; 2014 Jun; 9(6):844-51. PubMed ID: 24806546
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody-Drug Conjugate.
    Anderson MG; Falls HD; Mitten MJ; Oleksijew A; Vaidya KS; Boghaert ER; Gao W; Palma JP; Cao D; Chia PL; John T; Gan HK; Scott AM; Reilly EB
    Mol Cancer Ther; 2020 Oct; 19(10):2117-2125. PubMed ID: 32847977
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.
    Li F; Emmerton KK; Jonas M; Zhang X; Miyamoto JB; Setter JR; Nicholas ND; Okeley NM; Lyon RP; Benjamin DR; Law CL
    Cancer Res; 2016 May; 76(9):2710-9. PubMed ID: 26921341
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.