BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

279 related articles for article (PubMed ID: 34551432)

  • 1. Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes.
    Saha LK; Murai Y; Saha S; Jo U; Tsuda M; Takeda S; Pommier Y
    Nucleic Acids Res; 2021 Oct; 49(18):10493-10506. PubMed ID: 34551432
    [TBL] [Abstract][Full Text] [Related]  

  • 2. XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA.
    Hirota K; Ooka M; Shimizu N; Yamada K; Tsuda M; Ibrahim MA; Yamada S; Sasanuma H; Masutani M; Takeda S
    Genes Cells; 2022 May; 27(5):331-344. PubMed ID: 35194903
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.
    Lin X; Jiang W; Rudolph J; Lee BJ; Luger K; Zha S
    Nucleic Acids Res; 2022 Apr; 50(7):3958-3973. PubMed ID: 35349716
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors.
    Hopkins TA; Shi Y; Rodriguez LE; Solomon LR; Donawho CK; DiGiammarino EL; Panchal SC; Wilsbacher JL; Gao W; Olson AM; Stolarik DF; Osterling DJ; Johnson EF; Maag D
    Mol Cancer Res; 2015 Nov; 13(11):1465-77. PubMed ID: 26217019
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib.
    Ding X; Zhu Z; Lapek J; McMillan EA; Zhang A; Chung CY; Dubbury S; Lapira J; Firdaus S; Kang X; Gao J; Oyer J; Chionis J; Rollins RA; Li L; Niessen S; Bagrodia S; Zhang L; VanArsdale T
    Sci Rep; 2022 Jul; 12(1):12501. PubMed ID: 35864202
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes.
    Saha LK; Saha S; Yang X; Huang SN; Sun Y; Jo U; Pommier Y
    Nat Commun; 2023 Apr; 14(1):1925. PubMed ID: 37024461
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.
    Vaz B; Popovic M; Newman JA; Fielden J; Aitkenhead H; Halder S; Singh AN; Vendrell I; Fischer R; Torrecilla I; Drobnitzky N; Freire R; Amor DJ; Lockhart PJ; Kessler BM; McKenna GW; Gileadi O; Ramadan K
    Mol Cell; 2016 Nov; 64(4):704-719. PubMed ID: 27871366
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
    Ryan K; Bolaňos B; Smith M; Palde PB; Cuenca PD; VanArsdale TL; Niessen S; Zhang L; Behenna D; Ornelas MA; Tran KT; Kaiser S; Lum L; Stewart A; Gajiwala KS
    J Biol Chem; 2021; 296():100251. PubMed ID: 33361107
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity.
    Chen HD; Chen CH; Wang YT; Guo N; Tian YN; Huan XJ; Song SS; He JX; Miao ZH
    Int J Cancer; 2019 Aug; 145(3):714-727. PubMed ID: 30675909
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols.
    Zhao ML; Stefanick DF; Nadalutti CA; Beard WA; Wilson SH; Horton JK
    DNA Repair (Amst); 2023 Jun; 126():103486. PubMed ID: 37028218
    [TBL] [Abstract][Full Text] [Related]  

  • 11. PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors.
    Parsels LA; Karnak D; Parsels JD; Zhang Q; Vélez-Padilla J; Reichert ZR; Wahl DR; Maybaum J; O'Connor MJ; Lawrence TS; Morgan MA
    Mol Cancer Res; 2018 Feb; 16(2):222-232. PubMed ID: 29133592
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Olaparib modulates DNA repair efficiency, sensitizes cervical cancer cells to cisplatin and exhibits anti-metastatic property.
    Prasad CB; Prasad SB; Yadav SS; Pandey LK; Singh S; Pradhan S; Narayan G
    Sci Rep; 2017 Oct; 7(1):12876. PubMed ID: 28993682
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.
    Shao Z; Lee BJ; Rouleau-Turcotte É; Langelier MF; Lin X; Estes VM; Pascal JM; Zha S
    Nucleic Acids Res; 2020 Sep; 48(17):9694-9709. PubMed ID: 32890402
    [TBL] [Abstract][Full Text] [Related]  

  • 14. PARP-DNA trapping ability of PARP inhibitors jeopardizes astrocyte viability: Implications for CNS disease therapeutics.
    Sinha A; Katyal S; Kauppinen TM
    Neuropharmacology; 2021 Apr; 187():108502. PubMed ID: 33631119
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials.
    Yuan B; Ye N; Song SS; Wang YT; Song Z; Chen HD; Chen CH; Huan XJ; Wang YQ; Su Y; Shen YY; Sun YM; Yang XY; Chen Y; Guo SY; Gan Y; Gao ZW; Chen XY; Ding J; He JX; Zhang A; Miao ZH
    Cancer Lett; 2017 Feb; 386():47-56. PubMed ID: 27847302
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.
    Murai J; Huang SY; Das BB; Renaud A; Zhang Y; Doroshow JH; Ji J; Takeda S; Pommier Y
    Cancer Res; 2012 Nov; 72(21):5588-99. PubMed ID: 23118055
    [TBL] [Abstract][Full Text] [Related]  

  • 17. CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.
    Zimmermann M; Murina O; Reijns MAM; Agathanggelou A; Challis R; Tarnauskaitė Ž; Muir M; Fluteau A; Aregger M; McEwan A; Yuan W; Clarke M; Lambros MB; Paneesha S; Moss P; Chandrashekhar M; Angers S; Moffat J; Brunton VG; Hart T; de Bono J; Stankovic T; Jackson AP; Durocher D
    Nature; 2018 Jul; 559(7713):285-289. PubMed ID: 29973717
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways.
    Ghosh R; Roy S; Kamyab J; Danzter F; Franco S
    DNA Repair (Amst); 2016 Sep; 45():56-62. PubMed ID: 27373144
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.
    Wurster S; Hennes F; Parplys AC; Seelbach JI; Mansour WY; Zielinski A; Petersen C; Clauditz TS; Münscher A; Friedl AA; Borgmann K
    Oncotarget; 2016 Mar; 7(9):9732-41. PubMed ID: 26799421
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib.
    Murai J; Huang SY; Renaud A; Zhang Y; Ji J; Takeda S; Morris J; Teicher B; Doroshow JH; Pommier Y
    Mol Cancer Ther; 2014 Feb; 13(2):433-43. PubMed ID: 24356813
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.