BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

257 related articles for article (PubMed ID: 34552598)

  • 1. Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate Improves Host Control of
    van Doorn CLR; Schouten GK; van Veen S; Walburg KV; Esselink JJ; Heemskerk MT; Vrieling F; Ottenhoff THM
    Front Immunol; 2021; 12():739938. PubMed ID: 34552598
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis.
    Ferrarini MG; Nisimura LM; Girard RMBM; Alencar MB; Fragoso MSI; Araújo-Silva CA; Veiga AA; Abud APR; Nardelli SC; Vommaro RC; Silber AM; France-Sagot M; Ávila AR
    mSphere; 2021 Jan; 6(1):. PubMed ID: 33408226
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α.
    Škorja Milić N; Dolinar K; Miš K; Matkovič U; Bizjak M; Pavlin M; Podbregar M; Pirkmajer S
    Int J Mol Sci; 2021 Aug; 22(16):. PubMed ID: 34445316
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy.
    Anwar S; Shamsi A; Mohammad T; Islam A; Hassan MI
    Biochim Biophys Acta Rev Cancer; 2021 Aug; 1876(1):188568. PubMed ID: 34023419
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation.
    Kumar A; Kant S; Singh SM
    Toxicol Appl Pharmacol; 2013 Nov; 273(1):196-208. PubMed ID: 24051182
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.
    McCall CE; Zabalawi M; Liu T; Martin A; Long DL; Buechler NL; Arts RJW; Netea M; Yoza BK; Stacpoole PW; Vachharajani V
    JCI Insight; 2018 Aug; 3(15):. PubMed ID: 30089711
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pyruvate dehydrogenase kinase inhibitor dichloroacetate augments autophagy mediated constraining the replication of Mycobacteroides massiliense in macrophages.
    Quan H; Chung H; Je S; Hong JJ; Kim BJ; Na YR; Seok SH
    Microbes Infect; 2023; 25(7):105139. PubMed ID: 37085043
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy.
    Wei G; Sun J; Luan W; Hou Z; Wang S; Cui S; Cheng M; Liu Y
    J Med Chem; 2019 Oct; 62(19):8760-8772. PubMed ID: 31509699
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation.
    Min BK; Oh CJ; Park S; Lee JM; Go Y; Park BY; Kang HJ; Kim DW; Kim JE; Yoo EK; Kim HE; Kim MJ; Jeon YH; Kim YH; Lee CH; Jeon JH; Lee IK
    Exp Mol Med; 2019 Sep; 51(10):1-12. PubMed ID: 31570705
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells.
    de Mey S; Dufait I; Jiang H; Corbet C; Wang H; Van De Gucht M; Kerkhove L; Law KL; Vandenplas H; Gevaert T; Feron O; De Ridder M
    Int J Mol Sci; 2020 Dec; 21(24):. PubMed ID: 33316932
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity.
    Wu CY; Satapati S; Gui W; Wynn RM; Sharma G; Lou M; Qi X; Burgess SC; Malloy C; Khemtong C; Sherry AD; Chuang DT; Merritt ME
    J Biol Chem; 2018 Jun; 293(25):9604-9613. PubMed ID: 29739849
    [TBL] [Abstract][Full Text] [Related]  

  • 12. ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells.
    Cesi G; Walbrecq G; Zimmer A; Kreis S; Haan C
    Mol Cancer; 2017 Jun; 16(1):102. PubMed ID: 28595656
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Toll-Like receptor 2 (TLR2) and TLR9 play opposing roles in host innate immunity against Salmonella enterica serovar Typhimurium infection.
    Zhan R; Han Q; Zhang C; Tian Z; Zhang J
    Infect Immun; 2015 Apr; 83(4):1641-9. PubMed ID: 25667264
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent.
    Chiu HC; Kulp SK; Soni S; Wang D; Gunn JS; Schlesinger LS; Chen CS
    Antimicrob Agents Chemother; 2009 Dec; 53(12):5236-44. PubMed ID: 19805568
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate.
    Ferriero R; Iannuzzi C; Manco G; Brunetti-Pierri N
    J Inherit Metab Dis; 2015 Sep; 38(5):895-904. PubMed ID: 25601413
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice.
    Khang AR; Kim DH; Kim MJ; Oh CJ; Jeon JH; Choi SH; Lee IK
    Diabetes Metab J; 2024 May; 48(3):405-417. PubMed ID: 38311057
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury.
    Kho AR; Choi BY; Lee SH; Hong DK; Jeong JH; Kang BS; Kang DH; Park KH; Park JB; Suh SW
    Cells; 2019 May; 8(5):. PubMed ID: 31052436
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype.
    Min BK; Park S; Kang HJ; Kim DW; Ham HJ; Ha CM; Choi BJ; Lee JY; Oh CJ; Yoo EK; Kim HE; Kim BG; Jeon JH; Hyeon DY; Hwang D; Kim YH; Lee CH; Lee T; Kim JW; Choi YK; Park KG; Chawla A; Lee J; Harris RA; Lee IK
    Front Immunol; 2019; 10():944. PubMed ID: 31134063
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 15-Deoxy-Δ12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium.
    Buckner MM; Antunes LC; Gill N; Russell SL; Shames SR; Finlay BB
    PLoS One; 2013; 8(7):e69759. PubMed ID: 23922794
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The protected physiological state of intracellular Salmonella enterica persisters reduces host cell-imposed stress.
    Schulte M; Olschewski K; Hensel M
    Commun Biol; 2021 May; 4(1):520. PubMed ID: 33947954
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.