These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 34575505)

  • 1. Structure-Functional Analysis of Human Cytochrome P450 2C8 Using Directed Evolution.
    Lee R; Kim V; Chun Y; Kim D
    Pharmaceutics; 2021 Sep; 13(9):. PubMed ID: 34575505
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Directed-evolution analysis of human cytochrome P450 2A6 for enhanced enzymatic catalysis.
    Lee H; Kim JH; Han S; Lim YR; Park HG; Chun YJ; Park SW; Kim D
    J Toxicol Environ Health A; 2014; 77(22-24):1409-18. PubMed ID: 25343290
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.
    Melet A; Marques-Soares C; Schoch GA; Macherey AC; Jaouen M; Dansette PM; Sari MA; Johnson EF; Mansuy D
    Biochemistry; 2004 Dec; 43(49):15379-92. PubMed ID: 15581350
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F).
    Lee YB; Kim V; Lee SG; Lee GH; Kim C; Jeong E; Kim D
    Int J Mol Sci; 2023 Apr; 24(9):. PubMed ID: 37175734
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evaluation of Luminescent P450 Analysis for Directed Evolution of Human CYP4A11.
    Choi S; Han S; Lee H; Chun YJ; Kim D
    Biomol Ther (Seoul); 2013 Nov; 21(6):487-92. PubMed ID: 24404341
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Differential contribution of active site residues in substrate recognition sites 1 and 5 to cytochrome P450 2C8 substrate selectivity and regioselectivity.
    Kerdpin O; Elliot DJ; Boye SL; Birkett DJ; Yoovathaworn K; Miners JO
    Biochemistry; 2004 Jun; 43(24):7834-42. PubMed ID: 15196026
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8.
    Jiang H; Zhong F; Sun L; Feng W; Huang ZX; Tan X
    Amino Acids; 2011 Apr; 40(4):1195-204. PubMed ID: 20848147
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional characterization of CYP2C8.13 and CYP2C8.14: catalytic activities toward paclitaxel.
    Hanioka N; Matsumoto K; Saito Y; Narimatsu S
    Basic Clin Pharmacol Toxicol; 2010 Jul; 107(1):565-9. PubMed ID: 20148860
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6α-hydroxylation and amodiaquine N-deethylation.
    Tsukada C; Saito T; Maekawa M; Mano N; Oda A; Hirasawa N; Hiratsuka M
    Drug Metab Pharmacokinet; 2015 Oct; 30(5):366-73. PubMed ID: 26427316
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes.
    Yamazaki H; Shimada T
    Xenobiotica; 1999 Mar; 29(3):231-41. PubMed ID: 10219964
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation.
    Kim D; Guengerich FP
    Biochemistry; 2004 Feb; 43(4):981-8. PubMed ID: 14744142
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis.
    Kim D; Wu ZL; Guengerich FP
    J Biol Chem; 2005 Dec; 280(48):40319-27. PubMed ID: 16207711
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide.
    Kumar S; Chen CS; Waxman DJ; Halpert JR
    J Biol Chem; 2005 May; 280(20):19569-75. PubMed ID: 15774478
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.
    Dai D; Zeldin DC; Blaisdell JA; Chanas B; Coulter SJ; Ghanayem BI; Goldstein JA
    Pharmacogenetics; 2001 Oct; 11(7):597-607. PubMed ID: 11668219
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Polymorphisms of CYP2C8 Alter First-Electron Transfer Kinetics and Increase Catalytic Uncoupling.
    R Arnold W; Zelasko S; D Meling D; Sam K; Das A
    Int J Mol Sci; 2019 Sep; 20(18):. PubMed ID: 31540428
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Terfenadine metabolism of human cytochrome P450 2J2 containing genetic variations (G312R, P351L and P115L).
    Jeong D; Park HG; Lim YR; Lee Y; Kim V; Cho MA; Kim D
    Drug Metab Pharmacokinet; 2018 Feb; 33(1):61-66. PubMed ID: 29223463
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding.
    Kim D; Guengerich FP
    Arch Biochem Biophys; 2004 Dec; 432(1):102-8. PubMed ID: 15519301
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.
    Chang TK; Yu L; Goldstein JA; Waxman DJ
    Pharmacogenetics; 1997 Jun; 7(3):211-21. PubMed ID: 9241661
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.
    Zeldin DC; DuBois RN; Falck JR; Capdevila JH
    Arch Biochem Biophys; 1995 Sep; 322(1):76-86. PubMed ID: 7574697
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytochrome P450 2C8 (CYP2C8)-mediated hydroxylation of an endothelin ETA receptor antagonist in human liver microsomes.
    Ma B; Subramanian R; Schrag ML; Rodrigues AD; Tang C
    Drug Metab Dispos; 2004 May; 32(5):473-8. PubMed ID: 15100167
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.