BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

175 related articles for article (PubMed ID: 34576219)

  • 1. Discovery of a Non-Nucleoside SETD2 Methyltransferase Inhibitor against Acute Myeloid Leukemia.
    Bajusz D; Bognár Z; Ebner J; Grebien F; Keserű GM
    Int J Mol Sci; 2021 Sep; 22(18):. PubMed ID: 34576219
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.
    Le Coadou L; Berthelet J; Mechaly AE; Michail C; Bui LC; Dairou J; Haouz A; Dupret JM; Rodrigues Lima F
    Biochem Biophys Res Commun; 2024 Feb; 695():149400. PubMed ID: 38160530
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Benzene Hematotoxic and Reactive Metabolite 1,4-Benzoquinone Impairs the Activity of the Histone Methyltransferase SET Domain Containing 2 (SETD2) and Causes Aberrant Histone H3 Lysine 36 Trimethylation (H3K36me3).
    Berthelet J; Michail C; Bui LC; Le Coadou L; Sirri V; Wang L; Dulphy N; Dupret JM; Chomienne C; Guidez F; Rodrigues-Lima F
    Mol Pharmacol; 2021 Sep; 100(3):283-294. PubMed ID: 34266924
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells.
    Sheng Y; Ji Z; Zhao H; Wang J; Cheng C; Xu W; Wang X; He Y; Liu K; Li L; Voeltzel T; Maguer-Satta V; Gao WQ; Zhu HH
    Cell Prolif; 2019 Jul; 52(4):e12611. PubMed ID: 31054182
    [TBL] [Abstract][Full Text] [Related]  

  • 5. SETD2-dependent H3K36me3 plays a critical role in epigenetic regulation of the HPV31 life cycle.
    Gautam D; Johnson BA; Mac M; Moody CA
    PLoS Pathog; 2018 Oct; 14(10):e1007367. PubMed ID: 30312361
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.
    Fiskus W; Wang Y; Sreekumar A; Buckley KM; Shi H; Jillella A; Ustun C; Rao R; Fernandez P; Chen J; Balusu R; Koul S; Atadja P; Marquez VE; Bhalla KN
    Blood; 2009 Sep; 114(13):2733-43. PubMed ID: 19638619
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Roles of SETD2 in Leukemia-Transcription, DNA-Damage, and Beyond.
    Skucha A; Ebner J; Grebien F
    Int J Mol Sci; 2019 Feb; 20(5):. PubMed ID: 30818762
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Epigenetic therapies by targeting aberrant histone methylome in AML: molecular mechanisms, current preclinical and clinical development.
    Tsai CT; So CW
    Oncogene; 2017 Mar; 36(13):1753-1759. PubMed ID: 27593928
    [TBL] [Abstract][Full Text] [Related]  

  • 9.
    Mar BG; Chu SH; Kahn JD; Krivtsov AV; Koche R; Castellano CA; Kotlier JL; Zon RL; McConkey ME; Chabon J; Chappell R; Grauman PV; Hsieh JJ; Armstrong SA; Ebert BL
    Blood; 2017 Dec; 130(24):2631-2641. PubMed ID: 29018079
    [TBL] [Abstract][Full Text] [Related]  

  • 10. SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.
    Bu J; Chen A; Yan X; He F; Dong Y; Zhou Y; He J; Zhan D; Lin P; Hayashi Y; Sun Y; Zhang Y; Xiao Z; Grimes HL; Wang QF; Huang G
    Leukemia; 2018 Apr; 32(4):890-899. PubMed ID: 29249820
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of functional cooperative mutations of SETD2 in human acute leukemia.
    Zhu X; He F; Zeng H; Ling S; Chen A; Wang Y; Yan X; Wei W; Pang Y; Cheng H; Hua C; Zhang Y; Yang X; Lu X; Cao L; Hao L; Dong L; Zou W; Wu J; Li X; Zheng S; Yan J; Zhou J; Zhang L; Mi S; Wang X; Zhang L; Zou Y; Chen Y; Geng Z; Wang J; Zhou J; Liu X; Wang J; Yuan W; Huang G; Cheng T; Wang QF
    Nat Genet; 2014 Mar; 46(3):287-93. PubMed ID: 24509477
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair.
    Ye J; Zha J; Shi Y; Li Y; Yuan D; Chen Q; Lin F; Fang Z; Yu Y; Dai Y; Xu B
    Clin Epigenetics; 2019 Oct; 11(1):137. PubMed ID: 31590682
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy response in Chinese acute myeloid leukemia patients.
    Wang S; Yuan X; Liu Y; Zhu K; Chen P; Yan H; Zhang D; Li X; Zeng H; Zhao X; Chen X; Zhou G; Cao S
    J Transl Med; 2019 Mar; 17(1):101. PubMed ID: 30922329
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibitors of LSD1 as a potential therapy for acute myeloid leukemia.
    Przespolewski A; Wang ES
    Expert Opin Investig Drugs; 2016 Jul; 25(7):771-80. PubMed ID: 27077938
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library.
    Gibbons GS; Chakraborty A; Grigsby SM; Umeano AC; Liao C; Moukha-Chafiq O; Pathak V; Mathew B; Lee YT; Dou Y; Schürer SC; Reynolds RC; Snowden TS; Nikolovska-Coleska Z
    Eur J Med Chem; 2020 Mar; 189():112023. PubMed ID: 31978781
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.
    Zhang X; Zheng X; Yang H; Yan J; Fu X; Wei R; Xu X; Zhang Z; Yu A; Zhou K; Ding J; Geng M; Huang X
    Cancer Lett; 2018 Sep; 431():150-160. PubMed ID: 29857126
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines.
    Kondengaden SM; Luo LF; Huang K; Zhu M; Zang L; Bataba E; Wang R; Luo C; Wang B; Li KK; Wang PG
    Eur J Med Chem; 2016 Oct; 122():382-393. PubMed ID: 27393948
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2
    Song J; Du L; Liu P; Wang F; Zhang B; Xie Y; Lu J; Jin Y; Zhou Y; Lv G; Zhang J; Chen S; Chen Z; Sun X; Zhang Y; Huang Q
    Cancer Commun (Lond); 2021 Sep; 41(9):867-888. PubMed ID: 34196511
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors.
    Hou Z; Min W; Zhang R; Niu A; Li Y; Cao L; Han J; Luo C; Yang P; Ding H
    Bioorg Med Chem Lett; 2020 May; 30(9):127061. PubMed ID: 32173197
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.
    Murray-Stewart T; Woster PM; Casero RA
    Amino Acids; 2014 Mar; 46(3):585-94. PubMed ID: 23508577
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.