BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

218 related articles for article (PubMed ID: 34583518)

  • 1. PROTAC cell permeability and oral bioavailability: a journey into uncharted territory.
    Poongavanam V; Kihlberg J
    Future Med Chem; 2022 Jan; 14(3):123-126. PubMed ID: 34583518
    [No Abstract]   [Full Text] [Related]  

  • 2. The application of ubiquitin ligases in the PROTAC drug design.
    Chen Y; Jin J
    Acta Biochim Biophys Sin (Shanghai); 2020 Jul; 52(7):776-790. PubMed ID: 32506133
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Special Focus Issue - Targeted protein degradation: a new paradigm in medicinal chemistry.
    Wall H
    Future Med Chem; 2022 Jan; 14(3):115-117. PubMed ID: 35080920
    [No Abstract]   [Full Text] [Related]  

  • 4. Proteolysis-targeting chimeras: a kaleidoscope of targeted protein degradation.
    Mou Y; Wen S; Gao X; Jiang ZY
    Future Med Chem; 2022 Jan; 14(3):139-141. PubMed ID: 34814705
    [No Abstract]   [Full Text] [Related]  

  • 5. Small-molecule PROTACs: novel agents for cancer therapy.
    Wan Y; Yan C; Gao H; Liu T
    Future Med Chem; 2020 May; 12(10):915-938. PubMed ID: 32270707
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The Present and Future of Novel Protein Degradation Technology.
    Xia L; Liu W; Song Y; Zhu H; Duan Y
    Curr Top Med Chem; 2019; 19(20):1784-1788. PubMed ID: 31644408
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Arvinas's PROTACs pass first safety and PK analysis.
    Mullard A
    Nat Rev Drug Discov; 2019 Nov; 18(12):895. PubMed ID: 31780851
    [No Abstract]   [Full Text] [Related]  

  • 8. An E3 ligase guide to the galaxy of small-molecule-induced protein degradation.
    Jevtić P; Haakonsen DL; Rapé M
    Cell Chem Biol; 2021 Jul; 28(7):1000-1013. PubMed ID: 33891901
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeted protein degradation: expanding the toolbox.
    Schapira M; Calabrese MF; Bullock AN; Crews CM
    Nat Rev Drug Discov; 2019 Dec; 18(12):949-963. PubMed ID: 31666732
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The role of reversible and irreversible covalent chemistry in targeted protein degradation.
    Kiely-Collins H; Winter GE; Bernardes GJL
    Cell Chem Biol; 2021 Jul; 28(7):952-968. PubMed ID: 33789091
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity.
    Klein VG; Bond AG; Craigon C; Lokey RS; Ciulli A
    J Med Chem; 2021 Dec; 64(24):18082-18101. PubMed ID: 34881891
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Drugging the undruggable: targeting challenging E3 ligases for personalized medicine.
    Galdeano C
    Future Med Chem; 2017 Mar; 9(4):347-350. PubMed ID: 28263082
    [No Abstract]   [Full Text] [Related]  

  • 13. A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands.
    Han B
    J Biol Chem; 2020 Nov; 295(45):15280-15291. PubMed ID: 32859748
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
    Bondeson DP; Smith BE; Burslem GM; Buhimschi AD; Hines J; Jaime-Figueroa S; Wang J; Hamman BD; Ishchenko A; Crews CM
    Cell Chem Biol; 2018 Jan; 25(1):78-87.e5. PubMed ID: 29129718
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A caged E3 ligase ligand for PROTAC-mediated protein degradation with light.
    Kounde CS; Shchepinova MM; Saunders CN; Muelbaier M; Rackham MD; Harling JD; Tate EW
    Chem Commun (Camb); 2020 May; 56(41):5532-5535. PubMed ID: 32297626
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Paving the way to targeting HECT ubiquitin ligases.
    Zinzalla G
    Future Med Chem; 2015; 7(16):2107-11. PubMed ID: 26510616
    [No Abstract]   [Full Text] [Related]  

  • 17. E3 Ubiquitin Ligases as Molecular Targets in Human Oral Cancers.
    Masumoto K; Kitagawa M
    Curr Cancer Drug Targets; 2016; 16(2):130-5. PubMed ID: 26560119
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of IAP-recruiting BCL-X
    Zhang X; He Y; Zhang P; Budamagunta V; Lv D; Thummuri D; Yang Y; Pei J; Yuan Y; Zhou D; Zheng G
    Eur J Med Chem; 2020 Aug; 199():112397. PubMed ID: 32388279
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.
    Anumala UR; Waaler J; Nkizinkiko Y; Ignatev A; Lazarow K; Lindemann P; Olsen PA; Murthy S; Obaji E; Majouga AG; Leonov S; von Kries JP; Lehtiö L; Krauss S; Nazaré M
    J Med Chem; 2017 Dec; 60(24):10013-10025. PubMed ID: 29155568
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase.
    Degorce SL; Tavana O; Banks E; Crafter C; Gingipalli L; Kouvchinov D; Mao Y; Pachl F; Solanki A; Valge-Archer V; Yang B; Edmondson SD
    J Med Chem; 2020 Sep; 63(18):10460-10473. PubMed ID: 32803978
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.