227 related articles for article (PubMed ID: 34591488)
1. Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.
Subbaiah MAM; Meanwell NA
J Med Chem; 2021 Oct; 64(19):14046-14128. PubMed ID: 34591488
[TBL] [Abstract][Full Text] [Related]
2. Advances in nonclassical phenyl bioisosteres for drug structural optimization.
Li H; Gao Y; Ma J
Future Med Chem; 2022 Nov; 14(22):1681-1692. PubMed ID: 36317661
[TBL] [Abstract][Full Text] [Related]
3. Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.
Meanwell NA
Chem Res Toxicol; 2011 Sep; 24(9):1420-56. PubMed ID: 21790149
[TBL] [Abstract][Full Text] [Related]
4. Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere.
Rodríguez Sarmiento RM; Bissantz C; Bylund J; Limberg A; Neidhart W; Jakob-Roetne R; Wang L; Baumann K
J Med Chem; 2020 Aug; 63(15):8534-8553. PubMed ID: 32706964
[TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors.
Zarghi A; Kakhgi S; Hadipoor A; Daraee B; Dadrass OG; Hedayati M
Bioorg Med Chem Lett; 2008 Feb; 18(4):1336-9. PubMed ID: 18226898
[TBL] [Abstract][Full Text] [Related]
6. Applications of fluorine to the construction of bioisosteric elements for the purposes of novel drug discovery.
Richardson P
Expert Opin Drug Discov; 2021 Nov; 16(11):1261-1286. PubMed ID: 34074189
[No Abstract] [Full Text] [Related]
7. Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials.
Tse EG; Houston SD; Williams CM; Savage GP; Rendina LM; Hallyburton I; Anderson M; Sharma R; Walker GS; Obach RS; Todd MH
J Med Chem; 2020 Oct; 63(20):11585-11601. PubMed ID: 32678591
[TBL] [Abstract][Full Text] [Related]
8. 2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring.
Denisenko A; Garbuz P; Voloshchuk NM; Holota Y; Al-Maali G; Borysko P; Mykhailiuk PK
Nat Chem; 2023 Aug; 15(8):1155-1163. PubMed ID: 37277469
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.
Karig G; Large JM; Sharples CG; Sutherland A; Gallagher T; Wonnacott S
Bioorg Med Chem Lett; 2003 Sep; 13(17):2825-8. PubMed ID: 14611837
[TBL] [Abstract][Full Text] [Related]
10. Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space.
Meanwell NA
Chem Res Toxicol; 2016 Apr; 29(4):564-616. PubMed ID: 26974882
[TBL] [Abstract][Full Text] [Related]
11. Investigation of aryl halides as ketone bioisosteres: refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase).
McNulty J; Nielsen AJ; Brown CE; DiFrancesco BR; Vurgun N; Nair JJ; Crankshaw DJ; Holloway AC
Bioorg Med Chem Lett; 2013 Nov; 23(22):6060-3. PubMed ID: 24113062
[TBL] [Abstract][Full Text] [Related]
12. Applications of Bioisosteres in the Design of Biologically Active Compounds.
Meanwell NA
J Agric Food Chem; 2023 Nov; 71(47):18087-18122. PubMed ID: 36961953
[TBL] [Abstract][Full Text] [Related]
13. Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists.
Schlotter K; Boeckler F; Hübner H; Gmeiner P
J Med Chem; 2006 Jun; 49(12):3628-35. PubMed ID: 16759104
[TBL] [Abstract][Full Text] [Related]
14. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
Baum B; Muley L; Heine A; Smolinski M; Hangauer D; Klebe G
J Mol Biol; 2009 Aug; 391(3):552-64. PubMed ID: 19520086
[TBL] [Abstract][Full Text] [Related]
15. 2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring.
Levterov VV; Panasiuk Y; Sahun K; Stashkevych O; Badlo V; Shablykin O; Sadkova I; Bortnichuk L; Klymenko-Ulianov O; Holota Y; Lachmann L; Borysko P; Horbatok K; Bodenchuk I; Bas Y; Dudenko D; Mykhailiuk PK
Nat Commun; 2023 Oct; 14(1):5608. PubMed ID: 37783681
[TBL] [Abstract][Full Text] [Related]
16. The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?
Ritchie TJ; Macdonald SJ
Drug Discov Today; 2009 Nov; 14(21-22):1011-20. PubMed ID: 19729075
[TBL] [Abstract][Full Text] [Related]
17. Synthesis of tetraphenyl-substituted [12]cycloparaphenylene: toward a rationally designed ultrashort carbon nanotube.
Sisto TJ; Tian X; Jasti R
J Org Chem; 2012 Jul; 77(14):5857-60. PubMed ID: 22734917
[TBL] [Abstract][Full Text] [Related]
18. The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types.
Ritchie TJ; Macdonald SJ; Young RJ; Pickett SD
Drug Discov Today; 2011 Feb; 16(3-4):164-71. PubMed ID: 21129497
[TBL] [Abstract][Full Text] [Related]
19. Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold.
Marsilje TH; Alper PB; Lu W; Mutnick D; Michellys PY; He Y; Karanewsky DS; Chow D; Gerken A; Lao J; Kim MJ; Seidel HM; Tian SS
Bioorg Med Chem Lett; 2008 Oct; 18(19):5259-62. PubMed ID: 18783949
[TBL] [Abstract][Full Text] [Related]
20. Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes.
Tuccinardi T; Bertini S; Martinelli A; Minutolo F; Ortore G; Placanica G; Prota G; Rapposelli S; Carlson KE; Katzenellenbogen JA; Macchia M
J Med Chem; 2006 Aug; 49(16):5001-12. PubMed ID: 16884312
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]