These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

247 related articles for article (PubMed ID: 34593637)

  • 1. The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity.
    Snoznik C; Medvedeva V; Mojsilovic-Petrovic J; Rudich P; Oosten J; Kalb RG; Lamitina T
    Proc Natl Acad Sci U S A; 2021 Oct; 118(40):. PubMed ID: 34593637
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS.
    Jovičić A; Mertens J; Boeynaems S; Bogaert E; Chai N; Yamada SB; Paul JW; Sun S; Herdy JR; Bieri G; Kramer NJ; Gage FH; Van Den Bosch L; Robberecht W; Gitler AD
    Nat Neurosci; 2015 Sep; 18(9):1226-9. PubMed ID: 26308983
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
    Saberi S; Stauffer JE; Jiang J; Garcia SD; Taylor AE; Schulte D; Ohkubo T; Schloffman CL; Maldonado M; Baughn M; Rodriguez MJ; Pizzo D; Cleveland D; Ravits J
    Acta Neuropathol; 2018 Mar; 135(3):459-474. PubMed ID: 29196813
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans.
    Rudich P; Snoznik C; Watkins SC; Monaghan J; Pandey UB; Lamitina ST
    Hum Mol Genet; 2017 Dec; 26(24):4916-4928. PubMed ID: 29036691
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD.
    Westergard T; Jensen BK; Wen X; Cai J; Kropf E; Iacovitti L; Pasinelli P; Trotti D
    Cell Rep; 2016 Oct; 17(3):645-652. PubMed ID: 27732842
    [TBL] [Abstract][Full Text] [Related]  

  • 6. C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
    Licata NV; Cristofani R; Salomonsson S; Wilson KM; Kempthorne L; Vaizoglu D; D'Agostino VG; Pollini D; Loffredo R; Pancher M; Adami V; Bellosta P; Ratti A; Viero G; Quattrone A; Isaacs AM; Poletti A; Provenzani A
    EMBO J; 2022 Jan; 41(1):e105026. PubMed ID: 34791698
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration.
    Gomez-Deza J; Lee YB; Troakes C; Nolan M; Al-Sarraj S; Gallo JM; Shaw CE
    Acta Neuropathol Commun; 2015 Jun; 3():38. PubMed ID: 26108573
    [TBL] [Abstract][Full Text] [Related]  

  • 8. C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
    Beckers J; Tharkeshwar AK; Van Damme P
    Autophagy; 2021 Nov; 17(11):3306-3322. PubMed ID: 33632058
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients.
    Yin S; Lopez-Gonzalez R; Kunz RC; Gangopadhyay J; Borufka C; Gygi SP; Gao FB; Reed R
    Cell Rep; 2017 Jun; 19(11):2244-2256. PubMed ID: 28614712
    [TBL] [Abstract][Full Text] [Related]  

  • 10. C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.
    Moens TG; Niccoli T; Wilson KM; Atilano ML; Birsa N; Gittings LM; Holbling BV; Dyson MC; Thoeng A; Neeves J; Glaria I; Yu L; Bussmann J; Storkebaum E; Pardo M; Choudhary JS; Fratta P; Partridge L; Isaacs AM
    Acta Neuropathol; 2019 Mar; 137(3):487-500. PubMed ID: 30604225
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD.
    Andrade NS; Ramic M; Esanov R; Liu W; Rybin MJ; Gaidosh G; Abdallah A; Del'Olio S; Huff TC; Chee NT; Anatha S; Gendron TF; Wahlestedt C; Zhang Y; Benatar M; Mueller C; Zeier Z
    Mol Neurodegener; 2020 Feb; 15(1):13. PubMed ID: 32093728
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity.
    Bennett CL; Dastidar S; Arnold FJ; McKinstry SU; Stockford C; Freibaum BD; Sopher BL; Wu M; Seidner G; Joiner W; Taylor JP; West RJH; La Spada AR
    Acta Neuropathol Commun; 2023 Oct; 11(1):164. PubMed ID: 37845749
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity.
    Kramer NJ; Haney MS; Morgens DW; Jovičić A; Couthouis J; Li A; Ousey J; Ma R; Bieri G; Tsui CK; Shi Y; Hertz NT; Tessier-Lavigne M; Ichida JK; Bassik MC; Gitler AD
    Nat Genet; 2018 Apr; 50(4):603-612. PubMed ID: 29507424
    [TBL] [Abstract][Full Text] [Related]  

  • 14. C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration.
    May S; Hornburg D; Schludi MH; Arzberger T; Rentzsch K; Schwenk BM; Grässer FA; Mori K; Kremmer E; Banzhaf-Strathmann J; Mann M; Meissner F; Edbauer D
    Acta Neuropathol; 2014 Oct; 128(4):485-503. PubMed ID: 25120191
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins.
    Darling AL; Breydo L; Rivas EG; Gebru NT; Zheng D; Baker JD; Blair LJ; Dickey CA; Koren J; Uversky VN
    Int J Biol Macromol; 2019 Apr; 127():136-145. PubMed ID: 30639592
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD.
    Wang S; Latallo MJ; Zhang Z; Huang B; Bobrovnikov DG; Dong D; Livingston NM; Tjoeng W; Hayes LR; Rothstein JD; Ostrow LW; Wu B; Sun S
    Nat Commun; 2021 Aug; 12(1):4908. PubMed ID: 34389711
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells.
    Leskelä S; Huber N; Hoffmann D; Rostalski H; Remes AM; Takalo M; Hiltunen M; Haapasalo A
    Biochim Biophys Acta Mol Cell Res; 2021 Jun; 1868(7):119021. PubMed ID: 33775797
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Reduced autophagy upon C9ORF72 loss synergizes with dipeptide repeat protein toxicity in G4C2 repeat expansion disorders.
    Boivin M; Pfister V; Gaucherot A; Ruffenach F; Negroni L; Sellier C; Charlet-Berguerand N
    EMBO J; 2020 Feb; 39(4):e100574. PubMed ID: 31930538
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD.
    Khosravi B; LaClair KD; Riemenschneider H; Zhou Q; Frottin F; Mareljic N; Czuppa M; Farny D; Hartmann H; Michaelsen M; Arzberger T; Hartl FU; Hipp MS; Edbauer D
    EMBO J; 2020 Apr; 39(8):e102811. PubMed ID: 32175624
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
    Sonobe Y; Aburas J; Krishnan G; Fleming AC; Ghadge G; Islam P; Warren EC; Gu Y; Kankel MW; Brown AEX; Kiskinis E; Gendron TF; Gao FB; Roos RP; Kratsios P
    Nat Commun; 2021 Oct; 12(1):6025. PubMed ID: 34654821
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.