137 related articles for article (PubMed ID: 34593974)
1. HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson's disease models.
Zang CX; Wang L; Yang HY; Shang JM; Liu H; Zhang ZH; Ju C; Yuan FY; Li FY; Bao XQ; Zhang D
Acta Pharmacol Sin; 2022 Feb; 43(2):285-294. PubMed ID: 34593974
[TBL] [Abstract][Full Text] [Related]
2. The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1.
Torrino S; Visvikis O; Doye A; Boyer L; Stefani C; Munro P; Bertoglio J; Gacon G; Mettouchi A; Lemichez E
Dev Cell; 2011 Nov; 21(5):959-65. PubMed ID: 22036506
[TBL] [Abstract][Full Text] [Related]
3. HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi's Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity.
Kumar B; Roy A; Asha K; Sharma-Walia N; Ansari MA; Chandran B
J Virol; 2019 May; 93(9):. PubMed ID: 30787155
[TBL] [Abstract][Full Text] [Related]
4. The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation.
Castillo-Lluva S; Tan CT; Daugaard M; Sorensen PH; Malliri A
Oncogene; 2013 Mar; 32(13):1735-42. PubMed ID: 22614015
[TBL] [Abstract][Full Text] [Related]
5. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Rotblat B; Southwell AL; Ehrnhoefer DE; Skotte NH; Metzler M; Franciosi S; Leprivier G; Somasekharan SP; Barokas A; Deng Y; Tang T; Mathers J; Cetinbas N; Daugaard M; Kwok B; Li L; Carnie CJ; Fink D; Nitsch R; Galpin JD; Ahern CA; Melino G; Penninger JM; Hayden MR; Sorensen PH
Proc Natl Acad Sci U S A; 2014 Feb; 111(8):3032-7. PubMed ID: 24516159
[TBL] [Abstract][Full Text] [Related]
6. Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.
Daugaard M; Nitsch R; Razaghi B; McDonald L; Jarrar A; Torrino S; Castillo-Lluva S; Rotblat B; Li L; Malliri A; Lemichez E; Mettouchi A; Berman JN; Penninger JM; Sorensen PH
Nat Commun; 2013; 4():2180. PubMed ID: 23864022
[TBL] [Abstract][Full Text] [Related]
7. Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells.
Kim I; Shin SH; Lee JE; Park JW
Oncogene; 2019 May; 38(19):3651-3666. PubMed ID: 30659265
[TBL] [Abstract][Full Text] [Related]
8. Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
Andrio E; Lotte R; Hamaoui D; Cherfils J; Doye A; Daugaard M; Sorensen PH; Bost F; Ruimy R; Mettouchi A; Lemichez E
Sci Rep; 2017 Mar; 7():44779. PubMed ID: 28317937
[TBL] [Abstract][Full Text] [Related]
9. Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.
Acosta MI; Urbach S; Doye A; Ng YW; Boudeau J; Mettouchi A; Debant A; Manser E; Visvikis O; Lemichez E
Sci Rep; 2018 Jan; 8(1):1410. PubMed ID: 29362425
[TBL] [Abstract][Full Text] [Related]
10. MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease.
Yao L; Ye Y; Mao H; Lu F; He X; Lu G; Zhang S
J Neuroinflammation; 2018 Jan; 15(1):13. PubMed ID: 29329581
[TBL] [Abstract][Full Text] [Related]
11. HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner.
Turgu B; Zhang F; El-Naggar A; Negri GL; Kogler M; Tortola L; Johnson F; Ng T; Li A; Yapp D; Lockwood W; Martinez D; Maris JM; Daugaard M; Penninger JM; Hughes CS; Sorensen PH
Oncogene; 2021 Mar; 40(11):1988-2001. PubMed ID: 33603169
[TBL] [Abstract][Full Text] [Related]
12. HACE1 is a potential tumor suppressor in osteosarcoma.
El-Naggar AM; Clarkson PW; Negri GL; Turgu B; Zhang F; Anglesio MS; Sorensen PH
Cell Death Dis; 2019 Jan; 10(1):21. PubMed ID: 30622235
[TBL] [Abstract][Full Text] [Related]
13. Ubiquitylation of active Rac1 by the E3 ubiquitin-ligase HACE1.
Mettouchi A; Lemichez E
Small GTPases; 2012; 3(2):102-6. PubMed ID: 22790197
[TBL] [Abstract][Full Text] [Related]
14. HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.
Kogler M; Tortola L; Negri GL; Leopoldi A; El-Naggar AM; Mereiter S; Gomez-Diaz C; Nitsch R; Tortora D; Kavirayani AM; Gapp BV; Rao S; Uribesalgo I; Hoffmann D; Cikes D; Novatchkova M; Williams DA; Trent JM; Ikeda F; Daugaard M; Hagelkruys A; Sorensen PH; Penninger JM
Cancer Res; 2020 Jul; 80(14):3009-3022. PubMed ID: 32366477
[TBL] [Abstract][Full Text] [Related]
15. Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: A promising target.
Zang C; Liu H; Ning J; Chen Q; Jiang Y; Shang M; Yang Y; Ma J; Dong Y; Wang J; Li F; Bao X; Zhang D
Biomed Pharmacother; 2024 Mar; 172():116204. PubMed ID: 38364733
[TBL] [Abstract][Full Text] [Related]
16. The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes.
Turgu B; El-Naggar A; Kogler M; Tortola L; Zhang HF; Hassan M; Lizardo MM; Kung SH; Lam W; Penninger JM; Sorensen PH
EMBO Rep; 2023 Dec; 24(12):e56815. PubMed ID: 37846480
[TBL] [Abstract][Full Text] [Related]
17. Inhibition of esophageal cancer progression through HACE1-TRIP12 interaction and associated RAC1 ubiquitination and degradation.
Hu Y; Zhu Z; Xu Y; Zaman MF; Ge Y; Hu J; Tang X
J Cancer; 2024; 15(10):3114-3127. PubMed ID: 38706891
[No Abstract] [Full Text] [Related]
18. Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization.
Singh S; Machida S; Tulsian NK; Choong YK; Ng J; Shankar S; Liu Y; Chandiramani KV; Shi J; Sivaraman J
Adv Sci (Weinh); 2023 Sep; 10(27):e2207672. PubMed ID: 37537642
[TBL] [Abstract][Full Text] [Related]
19. MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease.
Yao L; Zhu Z; Wu J; Zhang Y; Zhang H; Sun X; Qian C; Wang B; Xie L; Zhang S; Lu G
FASEB J; 2019 Jul; 33(7):8648-8665. PubMed ID: 30995872
[TBL] [Abstract][Full Text] [Related]
20. Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression.
Goka ET; Lippman ME
Oncogene; 2015 Oct; 34(42):5395-405. PubMed ID: 25659579
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]