186 related articles for article (PubMed ID: 34615897)
1. PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages.
Obst J; Hall-Roberts HL; Smith TB; Kreuzer M; Magno L; Di Daniel E; Davis JB; Mead E
Sci Rep; 2021 Oct; 11(1):19842. PubMed ID: 34615897
[TBL] [Abstract][Full Text] [Related]
2. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
Andreone BJ; Przybyla L; Llapashtica C; Rana A; Davis SS; van Lengerich B; Lin K; Shi J; Mei Y; Astarita G; Di Paolo G; Sandmann T; Monroe KM; Lewcock JW
Nat Neurosci; 2020 Aug; 23(8):927-938. PubMed ID: 32514138
[TBL] [Abstract][Full Text] [Related]
3. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Hall-Roberts H; Agarwal D; Obst J; Smith TB; Monzón-Sandoval J; Di Daniel E; Webber C; James WS; Mead E; Davis JB; Cowley SA
Alzheimers Res Ther; 2020 Nov; 12(1):151. PubMed ID: 33198789
[TBL] [Abstract][Full Text] [Related]
4. The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.
Takalo M; Wittrahm R; Wefers B; Parhizkar S; Jokivarsi K; Kuulasmaa T; Mäkinen P; Martiskainen H; Wurst W; Xiang X; Marttinen M; Poutiainen P; Haapasalo A; Hiltunen M; Haass C
Mol Neurodegener; 2020 Sep; 15(1):52. PubMed ID: 32917267
[TBL] [Abstract][Full Text] [Related]
5. Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.
Reich M; Paris I; Ebeling M; Dahm N; Schweitzer C; Reinhardt D; Schmucki R; Prasad M; Köchl F; Leist M; Cowley SA; Zhang JD; Patsch C; Gutbier S; Britschgi M
Front Immunol; 2020; 11():617860. PubMed ID: 33613545
[TBL] [Abstract][Full Text] [Related]
6. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
Jairaman A; McQuade A; Granzotto A; Kang YJ; Chadarevian JP; Gandhi S; Parker I; Smith I; Cho H; Sensi SL; Othy S; Blurton-Jones M; Cahalan MD
Elife; 2022 Feb; 11():. PubMed ID: 35191835
[TBL] [Abstract][Full Text] [Related]
7. Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
Garcia-Reitboeck P; Phillips A; Piers TM; Villegas-Llerena C; Butler M; Mallach A; Rodrigues C; Arber CE; Heslegrave A; Zetterberg H; Neumann H; Neame S; Houlden H; Hardy J; Pocock JM
Cell Rep; 2018 Aug; 24(9):2300-2311. PubMed ID: 30157425
[TBL] [Abstract][Full Text] [Related]
8. Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Solomon S; Sampathkumar NK; Carre I; Mondal M; Chennell G; Vernon AC; Ruepp MD; Mitchell JC
Cell Mol Life Sci; 2022 Jul; 79(8):453. PubMed ID: 35895133
[TBL] [Abstract][Full Text] [Related]
9. The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.
Bull D; Matte JC; Navarron CM; McIntyre R; Whiting P; Katan M; Ducotterd F; Magno L
Biochim Biophys Acta Mol Basis Dis; 2024 Feb; 1870(2):166978. PubMed ID: 38061598
[TBL] [Abstract][Full Text] [Related]
10. Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes.
Olive C; Ibanez L; Farias FHG; Wang F; Budde JP; Norton JB; Gentsch J; Morris JC; Li Z; Dube U; Del-Aguila J; Bergmann K; Bradley J; Benitez BA; Harari O; Fagan A; Ances B; Cruchaga C; Fernandez MV
J Alzheimers Dis; 2020; 77(4):1469-1482. PubMed ID: 32894242
[TBL] [Abstract][Full Text] [Related]
11. Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.
Cosker K; Mallach A; Limaye J; Piers TM; Staddon J; Neame SJ; Hardy J; Pocock JM
Sci Rep; 2021 Jun; 11(1):13316. PubMed ID: 34172778
[TBL] [Abstract][Full Text] [Related]
12. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Nugent AA; Lin K; van Lengerich B; Lianoglou S; Przybyla L; Davis SS; Llapashtica C; Wang J; Kim DJ; Xia D; Lucas A; Baskaran S; Haddick PCG; Lenser M; Earr TK; Shi J; Dugas JC; Andreone BJ; Logan T; Solanoy HO; Chen H; Srivastava A; Poda SB; Sanchez PE; Watts RJ; Sandmann T; Astarita G; Lewcock JW; Monroe KM; Di Paolo G
Neuron; 2020 Mar; 105(5):837-854.e9. PubMed ID: 31902528
[TBL] [Abstract][Full Text] [Related]
13. MEK1/2 activity modulates TREM2 cell surface recruitment.
Schapansky J; Grinberg YY; Osiecki DM; Freeman EA; Walker SG; Karran E; Gopalakrishnan SM; Talanian RV
J Biol Chem; 2021; 296():100218. PubMed ID: 33839686
[TBL] [Abstract][Full Text] [Related]
14. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
Piers TM; Cosker K; Mallach A; Johnson GT; Guerreiro R; Hardy J; Pocock JM
FASEB J; 2020 Feb; 34(2):2436-2450. PubMed ID: 31907987
[TBL] [Abstract][Full Text] [Related]
15. PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522.
Maguire E; Menzies GE; Phillips T; Sasner M; Williams HM; Czubala MA; Evans N; Cope EL; Sims R; Howell GR; Lloyd-Evans E; Williams J; Allen ND; Taylor PR
EMBO J; 2021 Sep; 40(17):e105603. PubMed ID: 34254352
[TBL] [Abstract][Full Text] [Related]
16. Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Magno L; Lessard CB; Martins M; Lang V; Cruz P; Asi Y; Katan M; Bilsland J; Lashley T; Chakrabarty P; Golde TE; Whiting PJ
Alzheimers Res Ther; 2019 Feb; 11(1):16. PubMed ID: 30711010
[TBL] [Abstract][Full Text] [Related]
17. Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages.
Berner DK; Wessolowski L; Armbrust F; Schneppenheim J; Schlepckow K; Koudelka T; Scharfenberg F; Lucius R; Tholey A; Kleinberger G; Haass C; Arnold P; Becker-Pauly C
FASEB J; 2020 May; 34(5):6675-6687. PubMed ID: 32237095
[TBL] [Abstract][Full Text] [Related]
18. Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo.
Zhang L; Dong W; Ma Y; Bai L; Zhang X; Sun C; Li J; Zhang L
Mol Neurobiol; 2022 Jul; 59(7):4612-4629. PubMed ID: 35589918
[TBL] [Abstract][Full Text] [Related]
19. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.
Zhao P; Xu Y; Jiang LL; Fan X; Ku Z; Li L; Liu X; Deng M; Arase H; Zhu JJ; Huang TY; Zhao Y; Zhang C; Xu H; Tong Q; Zhang N; An Z
Mol Neurodegener; 2022 Jun; 17(1):44. PubMed ID: 35717259
[TBL] [Abstract][Full Text] [Related]
20. Neutrophil Phospholipase Cγ2 Drives Autoantibody-Induced Arthritis Through the Generation of the Inflammatory Microenvironment.
Futosi K; Kása O; Szilveszter KP; Mócsai A
Arthritis Rheumatol; 2021 Sep; 73(9):1614-1625. PubMed ID: 33645887
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]