These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

217 related articles for article (PubMed ID: 34619465)

  • 21. Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6.
    Osko JD; Porter NJ; Narayana Reddy PA; Xiao YC; Rokka J; Jung M; Hooker JM; Salvino JM; Christianson DW
    J Med Chem; 2020 Jan; 63(1):295-308. PubMed ID: 31793776
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology.
    Mondal P; Bai P; Gomm A; Bakiasi G; Lin CJ; Wang Y; Choi SH; Tanzi RE; Wang C; Zhang C
    Adv Sci (Weinh); 2024 Jan; 11(1):e2304545. PubMed ID: 37990786
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Recent advances in the discovery of potent and selective HDAC6 inhibitors.
    Wang XX; Wan RZ; Liu ZP
    Eur J Med Chem; 2018 Jan; 143():1406-1418. PubMed ID: 29133060
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?
    De Simone A; Milelli A
    ChemMedChem; 2019 Jun; 14(11):1067-1073. PubMed ID: 30958639
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.
    Leonhardt M; Sellmer A; Krämer OH; Dove S; Elz S; Kraus B; Beyer M; Mahboobi S
    Eur J Med Chem; 2018 May; 152():329-357. PubMed ID: 29738953
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.
    Senger J; Melesina J; Marek M; Romier C; Oehme I; Witt O; Sippl W; Jung M
    J Med Chem; 2016 Feb; 59(4):1545-55. PubMed ID: 26653328
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Involvement of HDAC6 in ischaemia and reperfusion-induced rat retinal injury.
    Yuan H; Li H; Yu P; Fan Q; Zhang X; Huang W; Shen J; Cui Y; Zhou W
    BMC Ophthalmol; 2018 Nov; 18(1):300. PubMed ID: 30453928
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Chiral mercaptoacetamides display enantioselective inhibition of histone deacetylase 6 and exhibit neuroprotection in cortical neuron models of oxidative stress.
    Kalin JH; Zhang H; Gaudrel-Grosay S; Vistoli G; Kozikowski AP
    ChemMedChem; 2012 Mar; 7(3):425-39. PubMed ID: 22234885
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.
    Vögerl K; Ong N; Senger J; Herp D; Schmidtkunz K; Marek M; Müller M; Bartel K; Shaik TB; Porter NJ; Robaa D; Christianson DW; Romier C; Sippl W; Jung M; Bracher F
    J Med Chem; 2019 Feb; 62(3):1138-1166. PubMed ID: 30645113
    [TBL] [Abstract][Full Text] [Related]  

  • 30. In silico design of HDAC6 inhibitors with neuroprotective effects.
    Sixto-López Y; Gómez-Vidal JA; de Pedro N; Bello M; Rosales-Hernández MC; Correa-Basurto J
    J Biomol Struct Dyn; 2022; 40(24):14204-14222. PubMed ID: 34784487
    [TBL] [Abstract][Full Text] [Related]  

  • 31. First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer's Disease.
    Santini A; Tassinari E; Poeta E; Loi M; Ciani E; Trazzi S; Piccarducci R; Daniele S; Martini C; Pagliarani B; Tarozzi A; Bersani M; Spyrakis F; Danková D; Olsen CA; Soldati R; Tumiatti V; Montanari S; De Simone A; Milelli A
    ACS Chem Neurosci; 2024 Jun; 15(11):2099-2111. PubMed ID: 38747979
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Metal-Free Direct Amidation of Naphthoquinones Using Hydroxamic Acids as an Amide Source: Application in the Synthesis of an HDAC6 Inhibitor.
    Zhang C; Chou CJ
    Org Lett; 2016 Nov; 18(21):5512-5515. PubMed ID: 27759399
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Beyond the Selective Inhibition of Histone Deacetylase 6.
    Rodrigues DA; Thota S; Fraga CA
    Mini Rev Med Chem; 2016; 16(14):1175-84. PubMed ID: 27121714
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Structural determinants of affinity and selectivity in the binding of inhibitors to histone deacetylase 6.
    Osko JD; Christianson DW
    Bioorg Med Chem Lett; 2020 Apr; 30(8):127023. PubMed ID: 32067866
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors.
    Rodrigues DA; Guerra FS; Sagrillo FS; de Sena M Pinheiro P; Alves MA; Thota S; Chaves LS; Sant'Anna CMR; Fernandes PD; Fraga CAM
    ChemMedChem; 2020 Mar; 15(6):539-551. PubMed ID: 32022441
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors.
    Porter NJ; Mahendran A; Breslow R; Christianson DW
    Proc Natl Acad Sci U S A; 2017 Dec; 114(51):13459-13464. PubMed ID: 29203661
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease.
    Benoy V; Vanden Berghe P; Jarpe M; Van Damme P; Robberecht W; Van Den Bosch L
    Neurotherapeutics; 2017 Apr; 14(2):417-428. PubMed ID: 27957719
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Histone deacetylase 6 interacts with the microtubule-associated protein tau.
    Ding H; Dolan PJ; Johnson GV
    J Neurochem; 2008 Sep; 106(5):2119-30. PubMed ID: 18636984
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Design, synthesis and neuroprotective biological evaluation of novel HDAC6 inhibitors incorporating benzothiadiazinyl systems as cap groups.
    Han B; Gu X; Wang M; Wang H; Sun N; Yang X; Zhang Q
    Chem Biol Drug Des; 2024 May; 103(5):e14556. PubMed ID: 38772881
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype.
    Olaoye OO; Watson PR; Nawar N; Geletu M; Sedighi A; Bukhari S; Raouf YS; Manaswiyoungkul P; Erdogan F; Abdeldayem A; Cabral AD; Hassan MM; Toutah K; Shouksmith AE; Gawel JM; Israelian J; Radu TB; Kachhiyapatel N; de Araujo ED; Christianson DW; Gunning PT
    J Med Chem; 2021 Mar; 64(5):2691-2704. PubMed ID: 33576627
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.