BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

137 related articles for article (PubMed ID: 34648813)

  • 21. CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide.
    Bidstrup TB; Bjørnsdottir I; Sidelmann UG; Thomsen MS; Hansen KT
    Br J Clin Pharmacol; 2003 Sep; 56(3):305-14. PubMed ID: 12919179
    [TBL] [Abstract][Full Text] [Related]  

  • 22. CYP3A4 and CYP2C19 genetic polymorphisms and myricetin interaction on tofacitinib metabolism.
    Ye Z; Xia H; Hu J; Liu YN; Wang A; Cai JP; Hu GX; Xu RA
    Biomed Pharmacother; 2024 Jun; 175():116421. PubMed ID: 38719708
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors.
    Murray M; Zhang WV; Edwards RJ
    Basic Clin Pharmacol Toxicol; 2018 Apr; 122(4):388-395. PubMed ID: 29155491
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants.
    Akiyoshi T; Saito T; Murase S; Miyazaki M; Murayama N; Yamazaki H; Guengerich FP; Nakamura K; Yamamoto K; Ohtani H
    Drug Metab Dispos; 2011 Apr; 39(4):724-8. PubMed ID: 21212239
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro.
    Bakken GV; Molden E; Knutsen K; Lunder N; Hermann M
    Drug Metab Dispos; 2012 Sep; 40(9):1778-84. PubMed ID: 22688609
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Preclinical assessment of the interactions between the antiretroviral drugs, ritonavir and efavirenz, and the tyrosine kinase inhibitor erlotinib.
    Deeken JF; Beumer JH; Anders NM; Wanjiku T; Rusnak M; Rudek MA
    Cancer Chemother Pharmacol; 2015 Oct; 76(4):813-9. PubMed ID: 26330331
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes.
    Zhang WV; D'Esposito F; Edwards RJ; Ramzan I; Murray M
    Drug Metab Dispos; 2008 Dec; 36(12):2547-55. PubMed ID: 18809730
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Functional characterization of 21 CYP3A4 variants on amiodarone metabolism in vitro.
    Yang CC; Zheng X; Liu TH; Wang CC; Tang PF; Chen Z; Zhang BW; Fang P; Hu GX; Cai JP
    Xenobiotica; 2019 Jan; 49(1):120-126. PubMed ID: 29394111
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Functional characterization of 27 CYP3A4 variants on macitentan metabolism in vitro.
    Li YH; Lu XR; Lin QM; Huang HL; Liang XL; Cai JP; Cui J; Hu GX
    J Pharm Pharmacol; 2019 Nov; 71(11):1677-1683. PubMed ID: 31441067
    [TBL] [Abstract][Full Text] [Related]  

  • 30. In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6.
    Weiss J; Sawa E; Riedel KD; Haefeli WE; Mikus G
    Naunyn Schmiedebergs Arch Pharmacol; 2008 Sep; 378(3):275-82. PubMed ID: 18516595
    [TBL] [Abstract][Full Text] [Related]  

  • 31. The effects of CYP3A4 induction and inhibition on the pharmacokinetics of alisporivir in humans.
    Barve A; Kovacs SJ; Ke J; Crabbe R; Grosgurin P; Menetrey A; Nicolas-Métral V; Dabovic K; Dole K; Zhang J; Praestgaard J; Sunkara G; Stein D
    Clin Pharmacol Drug Dev; 2015 Jan; 4(1):25-32. PubMed ID: 27128001
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Pharmacokinetics of vandetanib: three phase I studies in healthy subjects.
    Martin P; Oliver S; Kennedy SJ; Partridge E; Hutchison M; Clarke D; Giles P
    Clin Ther; 2012 Jan; 34(1):221-37. PubMed ID: 22206795
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Functional evaluation of CYP2C19 and CYP3A4 gene polymorphism on ibuprofen metabolism.
    Yuan LJ; Li XY; Ni JH; Wang J; Xu XY; Luo JC; Zhou Q; Hu GX; Cai JP; Qian JC
    Toxicol Appl Pharmacol; 2023 Sep; 475():116653. PubMed ID: 37574146
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes.
    Li J; Zhao M; He P; Hidalgo M; Baker SD
    Clin Cancer Res; 2007 Jun; 13(12):3731-7. PubMed ID: 17575239
    [TBL] [Abstract][Full Text] [Related]  

  • 35. In Vitro Kinetic Characterization of Axitinib Metabolism.
    Zientek MA; Goosen TC; Tseng E; Lin J; Bauman JN; Walker GS; Kang P; Jiang Y; Freiwald S; Neul D; Smith BJ
    Drug Metab Dispos; 2016 Jan; 44(1):102-14. PubMed ID: 26512042
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Inhibitory effect of ketoconazole on the pharmacokinetics of a multireceptor tyrosine kinase inhibitor BMS-690514 in healthy participants: assessing the mechanism of the interaction with physiologically-based pharmacokinetic simulations.
    Yang Z; Vakkalagadda B; Shen G; Ahlers CM; Has T; Christopher LJ; Kurland JF; Roongta V; Masson E; Zhang S
    J Clin Pharmacol; 2013 Feb; 53(2):217-27. PubMed ID: 23436267
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The impacts of CYP3A4 genetic polymorphism and drug interactions on the metabolism of lurasidone.
    Li Q; Wang J; Wang ZL; Shen Y; Zhou Q; Liu YN; Hu GX; Cai JP; Xu RA
    Biomed Pharmacother; 2023 Dec; 168():115833. PubMed ID: 37935069
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.
    Rakhit A; Pantze MP; Fettner S; Jones HM; Charoin JE; Riek M; Lum BL; Hamilton M
    Eur J Clin Pharmacol; 2008 Jan; 64(1):31-41. PubMed ID: 18000659
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.
    Dowty ME; Lin J; Ryder TF; Wang W; Walker GS; Vaz A; Chan GL; Krishnaswami S; Prakash C
    Drug Metab Dispos; 2014 Apr; 42(4):759-73. PubMed ID: 24464803
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.
    Natsui K; Mizuno Y; Tani N; Yabuki M; Komuro S
    Eur J Drug Metab Pharmacokinet; 2007; 32(4):233-40. PubMed ID: 18348473
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.