BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 34651016)

  • 1. Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts.
    Widjaja AA; Viswanathan S; Jinrui D; Singh BK; Tan J; Wei Ting JG; Lamb D; Shekeran SG; George BL; Schafer S; Carling D; Adami E; Cook SA
    Front Mol Biosci; 2021; 8():740650. PubMed ID: 34651016
    [TBL] [Abstract][Full Text] [Related]  

  • 2. IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.
    Adami E; Viswanathan S; Widjaja AA; Ng B; Chothani S; Zhihao N; Tan J; Lio PM; George BL; Altunoglu U; Ghosh K; Paleja BS; Schafer S; Reversade B; Albani S; Ling ALH; O'Reilly S; Cook SA
    Rheumatology (Oxford); 2021 Dec; 60(12):5820-5826. PubMed ID: 33590875
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.
    Widjaja AA; Singh BK; Adami E; Viswanathan S; Dong J; D'Agostino GA; Ng B; Lim WW; Tan J; Paleja BS; Tripathi M; Lim SY; Shekeran SG; Chothani SP; Rabes A; Sombetzki M; Bruinstroop E; Min LP; Sinha RA; Albani S; Yen PM; Schafer S; Cook SA
    Gastroenterology; 2019 Sep; 157(3):777-792.e14. PubMed ID: 31078624
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease.
    Ng B; Dong J; Viswanathan S; Widjaja AA; Paleja BS; Adami E; Ko NSJ; Wang M; Lim S; Tan J; Chothani SP; Albani S; Schafer S; Cook SA
    FASEB J; 2020 Sep; 34(9):11802-11815. PubMed ID: 32656894
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling.
    Dong J; Viswanathan S; Adami E; Schafer S; Kuthubudeen FF; Widjaja AA; Cook SA
    Elife; 2021 Aug; 10():. PubMed ID: 34435951
    [TBL] [Abstract][Full Text] [Related]  

  • 6. IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.
    Tan Y; Mosallanejad K; Zhang Q; O'Brien S; Clements M; Perper S; Wilson S; Chaulagain S; Wang J; Abdalla M; Al-Saidi H; Butt D; Clabbers A; Ofori K; Dillon B; Harvey B; Memmott J; Negron C; Winarta D; Tan C; Biswas A; Dong F; Morales-Tirado V; Lu X; Singh G; White M; Ashley S; Knight H; Westmoreland S; Phillips L; Carr T; Reinke-Breen L; Singh R; Xu J; Wu K; Rinaldi L; Stoll B; He YD; Hazelwood L; Karman J; McCluskey A; Stine W; Correia I; Gauld S; Levesque MC; Veldman G; Hubeau C; Radstake T; Sadhukhan R; Fiebiger E
    Front Immunol; 2024; 15():1293883. PubMed ID: 38455057
    [TBL] [Abstract][Full Text] [Related]  

  • 7. IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues.
    Widjaja AA; Chothani S; Viswanathan S; Goh JWT; Lim WW; Cook SA
    Int J Mol Sci; 2022 Aug; 23(16):. PubMed ID: 36012165
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.
    Ng B; Widjaja AA; Viswanathan S; Dong J; Chothani SP; Lim S; Shekeran SG; Tan J; McGregor NE; Walker EC; Sims NA; Schafer S; Cook SA
    Sci Rep; 2021 Jul; 11(1):14088. PubMed ID: 34239012
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload.
    Lim WW; Corden B; Ye L; Viswanathan S; Widjaja AA; Xie C; Su L; Tee NGZ; Schafer S; Cook SA
    Clin Exp Pharmacol Physiol; 2021 Apr; 48(4):605-613. PubMed ID: 33462828
    [TBL] [Abstract][Full Text] [Related]  

  • 10. IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis.
    Ng B; Viswanathan S; Widjaja AA; Lim WW; Shekeran SG; Goh JWT; Tan J; Kuthubudeen F; Lim SY; Xie C; Schafer S; Adami E; Cook SA
    Int J Mol Sci; 2022 Mar; 23(7):. PubMed ID: 35408908
    [TBL] [Abstract][Full Text] [Related]  

  • 11. IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells.
    Widjaja AA; Viswanathan S; Wei Ting JG; Tan J; Shekeran SG; Carling D; Lim WW; Cook SA
    iScience; 2022 Aug; 25(8):104806. PubMed ID: 35992082
    [TBL] [Abstract][Full Text] [Related]  

  • 12. IL-11 is a crucial determinant of cardiovascular fibrosis.
    Schafer S; Viswanathan S; Widjaja AA; Lim WW; Moreno-Moral A; DeLaughter DM; Ng B; Patone G; Chow K; Khin E; Tan J; Chothani SP; Ye L; Rackham OJL; Ko NSJ; Sahib NE; Pua CJ; Zhen NTG; Xie C; Wang M; Maatz H; Lim S; Saar K; Blachut S; Petretto E; Schmidt S; Putoczki T; Guimarães-Camboa N; Wakimoto H; van Heesch S; Sigmundsson K; Lim SL; Soon JL; Chao VTT; Chua YL; Tan TE; Evans SM; Loh YJ; Jamal MH; Ong KK; Chua KC; Ong BH; Chakaramakkil MJ; Seidman JG; Seidman CE; Hubner N; Sin KYK; Cook SA
    Nature; 2017 Dec; 552(7683):110-115. PubMed ID: 29160304
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.
    Widjaja AA; Dong J; Adami E; Viswanathan S; Ng B; Pakkiri LS; Chothani SP; Singh BK; Lim WW; Zhou J; Shekeran SG; Tan J; Lim SY; Goh J; Wang M; Holgate R; Hearn A; Felkin LE; Yen PM; Dear JW; Drum CL; Schafer S; Cook SA
    Sci Transl Med; 2021 Jun; 13(597):. PubMed ID: 34108253
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models.
    Lim WW; Corden B; Ng B; Vanezis K; D'Agostino G; Widjaja AA; Song WH; Xie C; Su L; Kwek XY; Tee NGZ; Dong J; Ko NSJ; Wang M; Pua CJ; Jamal MH; Soh B; Viswanathan S; Schafer S; Cook SA
    Sci Rep; 2020 Oct; 10(1):17853. PubMed ID: 33082445
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Critical Conditions for Studying Interleukin-11 Signaling In Vitro and Avoiding Experimental Artefacts.
    Viswanathan S; Ng B; Widjaja AA; Pua CJ; Tham N; Tan J; Cook SA; Schafer S
    Curr Protoc; 2021 Sep; 1(9):e251. PubMed ID: 34570432
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Fibroblast-matrix interplay: Nintedanib and pirfenidone modulate the effect of IPF fibroblast-conditioned matrix on normal fibroblast phenotype.
    Epstein Shochet G; Wollin L; Shitrit D
    Respirology; 2018 Aug; 23(8):756-763. PubMed ID: 29532550
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction.
    Sweeney M; O'Fee K; Villanueva-Hayes C; Rahman E; Lee M; Vanezis K; Andrew I; Lim WW; Widjaja A; Barton PJR; Cook SA
    Int J Mol Sci; 2023 Aug; 24(16):. PubMed ID: 37629170
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 5-HT
    Chaturvedi S; Misra DP; Prasad N; Rastogi K; Singh H; Rai MK; Agarwal V
    Int J Rheum Dis; 2018 Dec; 21(12):2128-2138. PubMed ID: 30207074
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice.
    Lim WW; Ng B; Widjaja A; Xie C; Su L; Ko N; Lim SY; Kwek XY; Lim S; Cook SA; Schafer S
    PLoS One; 2020; 15(1):e0227505. PubMed ID: 31917819
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of mast cells: a novel mechanism by which nintedanib may elicit anti-fibrotic effects.
    Overed-Sayer C; Miranda E; Dunmore R; Liarte Marin E; Beloki L; Rassl D; Parfrey H; Carruthers A; Chahboub A; Koch S; Güler-Gane G; Kuziora M; Lewis A; Murray L; May R; Clarke D
    Thorax; 2020 Sep; 75(9):754-763. PubMed ID: 32709610
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.