BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 34662125)

  • 21. Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors.
    Jing T; Miao X; Jiang F; Guo M; Xing L; Zhang J; Zuo D; Lei H; Zhai X
    Bioorg Med Chem; 2018 May; 26(8):1784-1796. PubMed ID: 29496411
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Convergent
    Petersen IN; Villadsen J; Hansen HD; Jensen AA; Lehel S; Gillings N; Herth MM; Knudsen GM; Kristensen JL
    Bioorg Med Chem; 2016 Nov; 24(21):5353-5356. PubMed ID: 27624522
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.
    Joncour A; Desroy N; Housseman C; Bock X; Bienvenu N; Cherel L; Labeguere V; Peixoto C; Annoot D; Lepissier L; Heiermann J; Hengeveld WJ; Pilzak G; Monjardet A; Wakselman E; Roncoroni V; Le Tallec S; Galien R; David C; Vandervoort N; Christophe T; Conrath K; Jans M; Wohlkonig A; Soror S; Steyaert J; Touitou R; Fleury D; Vercheval L; Mollat P; Triballeau N; van der Aar E; Brys R; Heckmann B
    J Med Chem; 2017 Sep; 60(17):7371-7392. PubMed ID: 28731719
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.
    Castagna D; Budd DC; Macdonald SJ; Jamieson C; Watson AJ
    J Med Chem; 2016 Jun; 59(12):5604-21. PubMed ID: 26745766
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Fluorine-18 click radiosynthesis and preclinical evaluation of a new 18F-labeled folic acid derivative.
    Ross TL; Honer M; Lam PY; Mindt TL; Groehn V; Schibli R; Schubiger PA; Ametamey SM
    Bioconjug Chem; 2008 Dec; 19(12):2462-70. PubMed ID: 19053298
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model.
    Lei H; Li Z; Li T; Wu H; Yang J; Yang X; Yang Y; Jiang N; Zhai X
    Bioorg Chem; 2022 Mar; 120():105590. PubMed ID: 34998121
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors.
    Lei H; Wang X; Zhao G; Li T; Cui Y; Wu H; Yang J; Jiang N; Zhai X
    Eur J Med Chem; 2022 Jun; 236():114307. PubMed ID: 35436669
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Hybrid imidazo[1,2-a]pyridine analogs as potent ATX inhibitors with concrete in vivo antifibrosis effect.
    Li T; Lei H; Yang J; Cao Z; Yang Y; Liu Z; Sun R; Yang X; Zhai X
    Arch Pharm (Weinheim); 2022 Oct; 355(10):e2200171. PubMed ID: 35661405
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Radiosynthesis and biological evaluation of the new PDE10A radioligand [
    Wagner S; Teodoro R; Deuther-Conrad W; Kranz M; Scheunemann M; Fischer S; Wenzel B; Egerland U; Hoefgen N; Steinbach J; Brust P
    J Labelled Comp Radiopharm; 2017 Jan; 60(1):36-48. PubMed ID: 27896836
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Design, synthesis, docking and biological evaluation of 4-phenyl-thiazole derivatives as autotaxin (ATX) inhibitors.
    Balupuri A; Lee DY; Lee MH; Chae S; Jung E; Kim Y; Ryu J; Kang NS
    Bioorg Med Chem Lett; 2017 Sep; 27(17):4156-4164. PubMed ID: 28743508
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition.
    Ragle LE; Palanisamy DJ; Joe MJ; Stein RS; Norman DD; Tigyi G; Baker DL; Parrill AL
    Bioorg Med Chem; 2016 Oct; 24(19):4660-4674. PubMed ID: 27544588
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model.
    Lei H; Cao Z; Wu H; Li T; Wang X; Chen Y; Ma E; Sun L; Zhai X
    Eur J Med Chem; 2022 Jan; 227():113951. PubMed ID: 34742015
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Benzoxaboroles-Novel Autotaxin Inhibitors.
    Kraljić K; Jelić D; Žiher D; Cvrtila A; Dragojević S; Sinković V; Mesić M
    Molecules; 2019 Sep; 24(19):. PubMed ID: 31547058
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2.
    Slavik R; Müller Herde A; Haider A; Krämer SD; Weber M; Schibli R; Ametamey SM; Mu L
    J Neurochem; 2016 Sep; 138(6):874-86. PubMed ID: 27385045
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography.
    Ritawidya R; Wenzel B; Teodoro R; Toussaint M; Kranz M; Deuther-Conrad W; Dukic-Stefanovic S; Ludwig FA; Scheunemann M; Brust P
    Molecules; 2019 Nov; 24(22):. PubMed ID: 31731831
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Structure-based discovery of (S)-2-amino-6-(4-fluorobenzyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione as low nanomolar, orally bioavailable autotaxin inhibitor.
    Roy A; Sarkar T; Datta S; Maiti A; Chakrabarti M; Mondal T; Mondal C; Banerjee A; Roy S; Mukherjee S; Muley P; Chakraborty S; Banerjee M; Kundu M; Roy KK
    Chem Biol Drug Des; 2022 Mar; 99(3):496-503. PubMed ID: 34951520
    [TBL] [Abstract][Full Text] [Related]  

  • 37. 5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography.
    Zhang Y; Pavlova OA; Chefer SI; Hall AW; Kurian V; Brown LL; Kimes AS; Mukhin AG; Horti AG
    J Med Chem; 2004 May; 47(10):2453-65. PubMed ID: 15115389
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Synthesis and evaluation of novel ¹⁸F labeled 2-pyridinylbenzoxazole and 2-pyridinylbenzothiazole derivatives as ligands for positron emission tomography (PET) imaging of β-amyloid plaques.
    Cui M; Wang X; Yu P; Zhang J; Li Z; Zhang X; Yang Y; Ono M; Jia H; Saji H; Liu B
    J Med Chem; 2012 Nov; 55(21):9283-96. PubMed ID: 22974116
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Evaluation of [
    Haider A; Wang L; Gobbi L; Li Y; Chaudhary A; Zhou X; Chen J; Zhao C; Rong J; Xiao Z; Hou L; Elghazawy NH; Sippl W; Davenport AT; Daunais JB; Ahmed H; Crowe R; Honer M; Rominger A; Grether U; Liang SH; Ametamey SM
    ACS Chem Neurosci; 2023 Oct; 14(20):3752-3760. PubMed ID: 37788055
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Rational design of caspase-responsive smart molecular probe for positron emission tomography imaging of drug-induced apoptosis.
    Qiu L; Wang W; Li K; Peng Y; Lv G; Liu Q; Gao F; Seimbille Y; Xie M; Lin J
    Theranostics; 2019; 9(23):6962-6975. PubMed ID: 31660080
    [No Abstract]   [Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.