These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
186 related articles for article (PubMed ID: 34668694)
1. Discovery of Next-Generation Tropomyosin Receptor Kinase Inhibitors for Combating Multiple Resistance Associated with Protein Mutation. Zhuo LS; Wang MS; Wu FX; Xu HC; Gong Y; Yu ZC; Tian YG; Pang C; Hao GF; Huang W; Yang GF J Med Chem; 2021 Oct; 64(20):15503-15514. PubMed ID: 34668694 [TBL] [Abstract][Full Text] [Related]
2. Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer. Liu Z; Yu P; Dong L; Wang W; Duan S; Wang B; Gong X; Ye L; Wang H; Tian J J Med Chem; 2021 Jul; 64(14):10286-10296. PubMed ID: 34253025 [TBL] [Abstract][Full Text] [Related]
3. Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents. Roa P; Foglizzo V; Harada G; Repetto M; Kulick A; de Stanchina E; de Marchena M; Auwardt S; Sayed Ahmed S; Bremer NV; Yang SR; Feng Y; Zhou C; Kong N; Liang R; Xu H; Zhang B; Bardelli A; Toska E; Ventura A; Drilon A; Cocco E Br J Cancer; 2024 Aug; 131(3):601-610. PubMed ID: 38902532 [TBL] [Abstract][Full Text] [Related]
4. Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Murray BW; Rogers E; Zhai D; Deng W; Chen X; Sprengeler PA; Zhang X; Graber A; Reich SH; Stopatschinskaja S; Solomon B; Besse B; Drilon A Mol Cancer Ther; 2021 Dec; 20(12):2446-2456. PubMed ID: 34625502 [No Abstract] [Full Text] [Related]
6. Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib. Xiang S; Lu X Acta Pharm Sin B; 2024 Feb; 14(2):517-532. PubMed ID: 38322338 [TBL] [Abstract][Full Text] [Related]
7. JND4135, a New Type II TRK Inhibitor, Overcomes TRK xDFG and Other Mutation Resistance In Vitro and In Vivo. Wang J; Zhou Y; Tang X; Yu X; Wang Y; Chan S; Song X; Tu Z; Zhang Z; Lu X; Zhang Z; Ding K Molecules; 2022 Oct; 27(19):. PubMed ID: 36235036 [TBL] [Abstract][Full Text] [Related]
8. Discovery of 3-pyrazolyl-substituted pyrazolo[1,5-a]pyrimidine derivatives as potent TRK inhibitors to overcome clinically acquired resistance. Gong Y; Wu FX; Wang MS; Xu HC; Zhuo LS; Yang GF; Huang W Eur J Med Chem; 2022 Nov; 241():114654. PubMed ID: 35961071 [TBL] [Abstract][Full Text] [Related]
9. Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. Wang Z; Wang J; Wang Y; Xiang S; Zhou H; Song S; Song X; Tu Z; Zhou Y; Ding K; Zhang ZM; Zhang Z; Lu X J Med Chem; 2023 Sep; 66(18):12950-12965. PubMed ID: 37676745 [TBL] [Abstract][Full Text] [Related]
10. Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases. Wang T; Lamb ML; Scott DA; Wang H; Block MH; Lyne PD; Lee JW; Davies AM; Zhang HJ; Zhu Y; Gu F; Han Y; Wang B; Mohr PJ; Kaus RJ; Josey JA; Hoffmann E; Thress K; Macintyre T; Wang H; Omer CA; Yu D J Med Chem; 2008 Aug; 51(15):4672-84. PubMed ID: 18646745 [TBL] [Abstract][Full Text] [Related]
12. Detecting and Targeting NTRK Fusions in Cancer in the Era of Tumor Agnostic Oncology. Rohrberg KS; Lassen U Drugs; 2021 Mar; 81(4):445-452. PubMed ID: 33400240 [TBL] [Abstract][Full Text] [Related]
13. Discovery of novel 3-(1H-pyrazol-4-yl)-1H-indazole derivatives as potent type II TRK inhibitors against acquired resistance. Qin Q; Guo Z; Lu S; Wang X; Fu Q; Wu T; Sun Y; Liu N; Zhang H; Zhao D; Cheng M Eur J Med Chem; 2024 Jan; 264():115953. PubMed ID: 38029466 [TBL] [Abstract][Full Text] [Related]
14. Discovery of novel indazole derivatives as second-generation TRK inhibitors. Qin Q; Lu S; Guo Z; Li Z; Fu Q; Wang X; Wu T; Sun Y; Liu N; Zhang H; Zhao D; Cheng M Eur J Med Chem; 2024 Oct; 276():116640. PubMed ID: 39033612 [TBL] [Abstract][Full Text] [Related]
15. Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors. Li P; Cai S; Zhao T; Xu L; Guan D; Li J; Zhou J; Zhang H Bioorg Med Chem Lett; 2021 Dec; 53():128409. PubMed ID: 34628036 [TBL] [Abstract][Full Text] [Related]
16. TRK inhibitors in TRK fusion-positive cancers. Drilon A Ann Oncol; 2019 Nov; 30 Suppl 8():viii23-viii30. PubMed ID: 32223935 [TBL] [Abstract][Full Text] [Related]
17. Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. Wang Z; Wang J; Wang Y; Xiang S; Song X; Tu Z; Zhou Y; Zhang ZM; Zhang Z; Ding K; Lu X J Med Chem; 2022 Apr; 65(8):6325-6337. PubMed ID: 35426680 [TBL] [Abstract][Full Text] [Related]
18. Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy. Xiang S; Wang J; Huang H; Wang Z; Song X; Zhou Y; Jin F; He X; Zhang ZM; Tu Z; Ding K; Zhang Z; Lu X Eur J Med Chem; 2023 Jan; 245(Pt 1):114899. PubMed ID: 36410169 [TBL] [Abstract][Full Text] [Related]
19. Pyrazolo[1,5-a]pyrimidine based Trk inhibitors: Design, synthesis, biological activity evaluation. Zhang Y; Liu Y; Zhou Y; Zhang Q; Han T; Tang C; Fan W Bioorg Med Chem Lett; 2021 Jan; 31():127712. PubMed ID: 33246108 [TBL] [Abstract][Full Text] [Related]