235 related articles for article (PubMed ID: 34681880)
1. Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers.
Spinello A; Borišek J; Malcovati L; Magistrato A
Int J Mol Sci; 2021 Oct; 22(20):. PubMed ID: 34681880
[TBL] [Abstract][Full Text] [Related]
2. H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
Seiler M; Yoshimi A; Darman R; Chan B; Keaney G; Thomas M; Agrawal AA; Caleb B; Csibi A; Sean E; Fekkes P; Karr C; Klimek V; Lai G; Lee L; Kumar P; Lee SC; Liu X; Mackenzie C; Meeske C; Mizui Y; Padron E; Park E; Pazolli E; Peng S; Prajapati S; Taylor J; Teng T; Wang J; Warmuth M; Yao H; Yu L; Zhu P; Abdel-Wahab O; Smith PG; Buonamici S
Nat Med; 2018 May; 24(4):497-504. PubMed ID: 29457796
[TBL] [Abstract][Full Text] [Related]
3. The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.
Finci LI; Zhang X; Huang X; Zhou Q; Tsai J; Teng T; Agrawal A; Chan B; Irwin S; Karr C; Cook A; Zhu P; Reynolds D; Smith PG; Fekkes P; Buonamici S; Larsen NA
Genes Dev; 2018 Feb; 32(3-4):309-320. PubMed ID: 29491137
[TBL] [Abstract][Full Text] [Related]
4. In Silico Analysis of a Highly Mutated Gene in Cancer Provides Insight into Abnormal mRNA Splicing: Splicing Factor 3B Subunit 1
Samy A; Suzek BE; Ozdemir MK; Sensoy O
Biomolecules; 2020 Apr; 10(5):. PubMed ID: 32354150
[TBL] [Abstract][Full Text] [Related]
5. Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.
Obeng EA; Chappell RJ; Seiler M; Chen MC; Campagna DR; Schmidt PJ; Schneider RK; Lord AM; Wang L; Gambe RG; McConkey ME; Ali AM; Raza A; Yu L; Buonamici S; Smith PG; Mullally A; Wu CJ; Fleming MD; Ebert BL
Cancer Cell; 2016 Sep; 30(3):404-417. PubMed ID: 27622333
[TBL] [Abstract][Full Text] [Related]
6. Disclosing the Impact of Carcinogenic SF3b Mutations on Pre-mRNA Recognition Via All-Atom Simulations.
Borišek J; Saltalamacchia A; Gallì A; Palermo G; Molteni E; Malcovati L; Magistrato A
Biomolecules; 2019 Oct; 9(10):. PubMed ID: 31640290
[TBL] [Abstract][Full Text] [Related]
7.
López-Oreja I; Gohr A; Playa-Albinyana H; Giró A; Arenas F; Higashi M; Tripathi R; López-Guerra M; Irimia M; Aymerich M; Valcárcel J; Bonnal S; Colomer D
Life Sci Alliance; 2023 Nov; 6(11):. PubMed ID: 37562845
[TBL] [Abstract][Full Text] [Related]
8. Cancer-Related Mutations Alter RNA-Driven Functional Cross-Talk Underlying Premature-Messenger RNA Recognition by Splicing Factor SF3b.
Spinello A; Janos P; Rozza R; Magistrato A
J Phys Chem Lett; 2023 Jul; 14(27):6263-6269. PubMed ID: 37399065
[TBL] [Abstract][Full Text] [Related]
9. Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Teng T; Tsai JH; Puyang X; Seiler M; Peng S; Prajapati S; Aird D; Buonamici S; Caleb B; Chan B; Corson L; Feala J; Fekkes P; Gerard B; Karr C; Korpal M; Liu X; T Lowe J; Mizui Y; Palacino J; Park E; Smith PG; Subramanian V; Wu ZJ; Zou J; Yu L; Chicas A; Warmuth M; Larsen N; Zhu P
Nat Commun; 2017 May; 8():15522. PubMed ID: 28541300
[TBL] [Abstract][Full Text] [Related]
10. Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.
Mupo A; Seiler M; Sathiaseelan V; Pance A; Yang Y; Agrawal AA; Iorio F; Bautista R; Pacharne S; Tzelepis K; Manes N; Wright P; Papaemmanuil E; Kent DG; Campbell PC; Buonamici S; Bolli N; Vassiliou GS
Leukemia; 2017 Mar; 31(3):720-727. PubMed ID: 27604819
[TBL] [Abstract][Full Text] [Related]
11. Structures of SF3b1 reveal a dynamic Achilles heel of spliceosome assembly: Implications for cancer-associated abnormalities and drug discovery.
Maji D; Grossfield A; Kielkopf CL
Biochim Biophys Acta Gene Regul Mech; 2019; 1862(11-12):194440. PubMed ID: 31707043
[TBL] [Abstract][Full Text] [Related]
12. A Comprehensive Overview of Structure-Activity Relationships of Small-Molecule Splicing Modulators Targeting SF3B1 as Anticancer Agents.
Zhang D; Meng F
ChemMedChem; 2020 Nov; 15(22):2098-2120. PubMed ID: 33037739
[TBL] [Abstract][Full Text] [Related]
13. Exploiting Cryo-EM Structural Information and All-Atom Simulations To Decrypt the Molecular Mechanism of Splicing Modulators.
Borišek J; Saltalamacchia A; Spinello A; Magistrato A
J Chem Inf Model; 2020 May; 60(5):2510-2521. PubMed ID: 31539251
[TBL] [Abstract][Full Text] [Related]
14. Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1.
Zhang J; Ali AM; Lieu YK; Liu Z; Gao J; Rabadan R; Raza A; Mukherjee S; Manley JL
Mol Cell; 2019 Oct; 76(1):82-95.e7. PubMed ID: 31474574
[TBL] [Abstract][Full Text] [Related]
15. SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing.
Tang Q; Rodriguez-Santiago S; Wang J; Pu J; Yuste A; Gupta V; Moldón A; Xu YZ; Query CC
Genes Dev; 2016 Dec; 30(24):2710-2723. PubMed ID: 28087715
[TBL] [Abstract][Full Text] [Related]
16. Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Cretu C; Schmitzová J; Ponce-Salvatierra A; Dybkov O; De Laurentiis EI; Sharma K; Will CL; Urlaub H; Lührmann R; Pena V
Mol Cell; 2016 Oct; 64(2):307-319. PubMed ID: 27720643
[TBL] [Abstract][Full Text] [Related]
17. Somatic
Foy A; McMullin MF
J Clin Pathol; 2019 Nov; 72(11):778-782. PubMed ID: 31473630
[TBL] [Abstract][Full Text] [Related]
18. Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.
Cretu C; Agrawal AA; Cook A; Will CL; Fekkes P; Smith PG; Lührmann R; Larsen N; Buonamici S; Pena V
Mol Cell; 2018 Apr; 70(2):265-273.e8. PubMed ID: 29656923
[TBL] [Abstract][Full Text] [Related]
19. Cancer-associated mutations in SF3B1 disrupt the interaction between SF3B1 and DDX42.
Zhao B; Li Z; Qian R; Liu G; Fan M; Liang Z; Hu X; Wan Y
J Biochem; 2022 Jul; 172(2):117-126. PubMed ID: 35652295
[TBL] [Abstract][Full Text] [Related]
20. SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A-c-Myc axis.
Yang JY; Huo YM; Yang MW; Shen Y; Liu DJ; Fu XL; Tao LY; He RZ; Zhang JF; Hua R; Jiang SH; Sun YW; Liu W
Mol Oncol; 2021 Nov; 15(11):3076-3090. PubMed ID: 33932092
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
