BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 34685571)

  • 1. A Novel Calpain Inhibitor Compound Has Protective Effects on a Zebrafish Model of Spinocerebellar Ataxia Type 3.
    Robinson KJ; Yuan K; Plenderleith SK; Watchon M; Laird AS
    Cells; 2021 Sep; 10(10):. PubMed ID: 34685571
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3.
    Watchon M; Robinson KJ; Luu L; An Y; Yuan KC; Plenderleith SK; Cheng F; Don EK; Nicholson GA; Lee A; Laird AS
    FASEB J; 2024 Jan; 38(2):e23429. PubMed ID: 38258931
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Autophagy Function and Benefits of Autophagy Induction in Models of Spinocerebellar Ataxia Type 3.
    Watchon M; Luu L; Plenderleith SK; Yuan KC; Laird AS
    Cells; 2023 Mar; 12(6):. PubMed ID: 36980234
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3.
    Robinson KJ; Tym MC; Hogan A; Watchon M; Yuan KC; Plenderleith SK; Don EK; Laird AS
    Dis Model Mech; 2021 Oct; 14(10):. PubMed ID: 34473252
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Calpain Inhibition Is Protective in Machado-Joseph Disease Zebrafish Due to Induction of Autophagy.
    Watchon M; Yuan KC; Mackovski N; Svahn AJ; Cole NJ; Goldsbury C; Rinkwitz S; Becker TS; Nicholson GA; Laird AS
    J Neurosci; 2017 Aug; 37(32):7782-7794. PubMed ID: 28687604
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
    Hübener J; Weber JJ; Richter C; Honold L; Weiss A; Murad F; Breuer P; Wüllner U; Bellstedt P; Paquet-Durand F; Takano J; Saido TC; Riess O; Nguyen HP
    Hum Mol Genet; 2013 Feb; 22(3):508-18. PubMed ID: 23100324
    [TBL] [Abstract][Full Text] [Related]  

  • 7. n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
    Rajamani K; Liu JW; Wu CH; Chiang IT; You DH; Lin SY; Hsieh DK; Lin SZ; Harn HJ; Chiou TW
    Neuropharmacology; 2017 May; 117():434-446. PubMed ID: 28223212
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Lysine 117 on ataxin-3 modulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.
    Blount JR; Patel NC; Libohova K; Harris AL; Tsou WL; Sujkowski A; Todi SV
    J Neurol Sci; 2023 Nov; 454():120828. PubMed ID: 37865002
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Spermidine treatment: induction of autophagy but also apoptosis?
    Watchon M; Wright AL; Ahel HI; Robinson KJ; Plenderleith SK; Kuriakose A; Yuan KC; Laird AS
    Mol Brain; 2024 Mar; 17(1):15. PubMed ID: 38443995
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3.
    Koike Y; Jansen-West KR; Hanna Al-Shaikh R; Carlomagno Y; Song Y; Dunmore JA; LeDoux MS; Friedman JH; Pena AB; Uitti RJ; Zaremba J; van Gerpen JA; Pfeiffer RF; Veerappan V; Aiba I; Hashimoto R; Giles SS; Shah JS; Tipton PW; Huang JF; Wierenga KJ; Aasly J; Fryer JD; Petrucelli L; Wszolek ZK; Prudencio M
    Parkinsonism Relat Disord; 2021 Aug; 89():151-154. PubMed ID: 34303201
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein.
    Ashraf NS; Sutton JR; Yang Y; Ranxhi B; Libohova K; Shaw ED; Barget AJ; Todi SV; Paulson HL; Costa MDC
    Neurobiol Dis; 2020 Apr; 137():104697. PubMed ID: 31783119
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3.
    Johnson SL; Libohova K; Blount JR; Sujkowski AL; Prifti MV; Tsou WL; Todi SV
    Neurobiol Dis; 2021 Dec; 160():105516. PubMed ID: 34563642
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.
    Li X; Liu H; Fischhaber PL; Tang TS
    Prog Neurobiol; 2015 Sep; 132():34-58. PubMed ID: 26123252
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vivo assessment of riluzole as a potential therapeutic drug for spinocerebellar ataxia type 3.
    Schmidt J; Schmidt T; Golla M; Lehmann L; Weber JJ; Hübener-Schmid J; Riess O
    J Neurochem; 2016 Jul; 138(1):150-62. PubMed ID: 26990650
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: removal of the CAG containing exon.
    Evers MM; Tran HD; Zalachoras I; Pepers BA; Meijer OC; den Dunnen JT; van Ommen GJ; Aartsma-Rus A; van Roon-Mom WM
    Neurobiol Dis; 2013 Oct; 58():49-56. PubMed ID: 23659897
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.
    Wu YL; Chang JC; Lin WY; Li CC; Hsieh M; Chen HW; Wang TS; Wu WT; Liu CS; Liu KL
    Free Radic Biol Med; 2018 Feb; 115():309-317. PubMed ID: 29247688
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons.
    Li YX; Sibon OCM; Dijkers PF
    J Neuroinflammation; 2018 Sep; 15(1):261. PubMed ID: 30205834
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes.
    Ramani B; Panwar B; Moore LR; Wang B; Huang R; Guan Y; Paulson HL
    Hum Mol Genet; 2017 Sep; 26(17):3362-3374. PubMed ID: 28854700
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Frequency of SCA1, SCA2, SCA3/MJD, SCA6, SCA7, and DRPLA CAG trinucleotide repeat expansion in patients with hereditary spinocerebellar ataxia from Chinese kindreds.
    Tang B; Liu C; Shen L; Dai H; Pan Q; Jing L; Ouyang S; Xia J
    Arch Neurol; 2000 Apr; 57(4):540-4. PubMed ID: 10768629
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Toxicity and aggregation of the polyglutamine disease protein, ataxin-3 is regulated by its binding to VCP/p97 in Drosophila melanogaster.
    Ristic G; Sutton JR; Libohova K; Todi SV
    Neurobiol Dis; 2018 Aug; 116():78-92. PubMed ID: 29704548
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.