BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

269 related articles for article (PubMed ID: 34689040)

  • 1. Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.
    Lichtenthaler SF; Tschirner SK; Steiner H
    Curr Opin Neurobiol; 2022 Feb; 72():101-110. PubMed ID: 34689040
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice.
    Tian T; Bai D; Li W; Huang GW; Liu H
    Nutrients; 2016 Sep; 8(9):. PubMed ID: 27618097
    [TBL] [Abstract][Full Text] [Related]  

  • 3. η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
    Willem M; Tahirovic S; Busche MA; Ovsepian SV; Chafai M; Kootar S; Hornburg D; Evans LD; Moore S; Daria A; Hampel H; Müller V; Giudici C; Nuscher B; Wenninger-Weinzierl A; Kremmer E; Heneka MT; Thal DR; Giedraitis V; Lannfelt L; Müller U; Livesey FJ; Meissner F; Herms J; Konnerth A; Marie H; Haass C
    Nature; 2015 Oct; 526(7573):443-7. PubMed ID: 26322584
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.
    Cai Z; Wang C; He W; Chen Y
    Curr Alzheimer Res; 2018; 15(11):1045-1052. PubMed ID: 29962345
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice.
    Mori T; Koyama N; Yokoo T; Segawa T; Maeda M; Sawmiller D; Tan J; Town T
    J Biol Chem; 2020 Nov; 295(48):16251-16266. PubMed ID: 32913125
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells.
    Panmanee J; Nopparat C; Chavanich N; Shukla M; Mukda S; Song W; Vincent B; Govitrapong P
    J Pineal Res; 2015 Oct; 59(3):308-20. PubMed ID: 26123100
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Revisiting APP secretases: an overview on the holistic effects of retinoic acid receptor stimulation in APP processing.
    Vitória JJM; Trigo D; da Cruz E Silva OAB
    Cell Mol Life Sci; 2022 Jan; 79(2):101. PubMed ID: 35089425
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A; Hata S; Suzuki T
    J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.
    Colombo A; Wang H; Kuhn PH; Page R; Kremmer E; Dempsey PJ; Crawford HC; Lichtenthaler SF
    Neurobiol Dis; 2013 Jan; 49():137-47. PubMed ID: 22940630
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.
    Mamada N; Tanokashira D; Ishii K; Tamaoka A; Araki W
    Biochem Biophys Res Commun; 2017 Apr; 486(2):321-328. PubMed ID: 28302486
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
    Harris B; Pereira I; Parkin E
    Brain Res; 2009 Nov; 1296():203-15. PubMed ID: 19679113
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease.
    Al-Atrache Z; Lopez DB; Hingley ST; Appelt DM
    BMC Neurosci; 2019 Feb; 20(1):6. PubMed ID: 30786875
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10.
    Hitschler L; Lang T
    J Biol Chem; 2022 Jun; 298(6):101911. PubMed ID: 35398353
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.
    Hogl S; Kuhn PH; Colombo A; Lichtenthaler SF
    PLoS One; 2011; 6(6):e21337. PubMed ID: 21695060
    [TBL] [Abstract][Full Text] [Related]  

  • 16. α-secretase ADAM10 physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis.
    Wang X; Wang C; Pei G
    J Mol Cell Biol; 2018 Oct; 10(5):411-422. PubMed ID: 29325091
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Alpha-secretase cleavage of the amyloid precursor protein: proteolysis regulated by signaling pathways and protein trafficking.
    Lichtenthaler SF
    Curr Alzheimer Res; 2012 Feb; 9(2):165-77. PubMed ID: 21605033
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.
    Corbett GT; Gonzalez FJ; Pahan K
    Proc Natl Acad Sci U S A; 2015 Jul; 112(27):8445-50. PubMed ID: 26080426
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Beta-secretase/BACE1 promotes APP endocytosis and processing in the endosomes and on cell membrane.
    Wang M; Jing T; Wang X; Yao D
    Neurosci Lett; 2018 Oct; 685():63-67. PubMed ID: 30120949
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition.
    Abraham CB; Xu L; Pantelopulos GA; Straub JE
    Biophys J; 2023 Oct; 122(19):3999-4010. PubMed ID: 37658602
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.