BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

328 related articles for article (PubMed ID: 34717253)

  • 1. Making and breaking carbon-carbon bonds in class C radical SAM methyltransferases.
    Brimberry MA; Mathew L; Lanzilotta W
    J Inorg Biochem; 2022 Jan; 226():111636. PubMed ID: 34717253
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily.
    Broderick WE; Hoffman BM; Broderick JB
    Acc Chem Res; 2018 Nov; 51(11):2611-2619. PubMed ID: 30346729
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of
    Impano S; Yang H; Jodts RJ; Pagnier A; Swimley R; McDaniel EC; Shepard EM; Broderick WE; Broderick JB; Hoffman BM
    J Am Chem Soc; 2021 Jan; 143(1):335-348. PubMed ID: 33372786
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Radical-mediated enzymatic methylation: a tale of two SAMS.
    Zhang Q; van der Donk WA; Liu W
    Acc Chem Res; 2012 Apr; 45(4):555-64. PubMed ID: 22097883
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Radical SAM enzymes: Nature's choice for radical reactions.
    Broderick JB; Broderick WE; Hoffman BM
    FEBS Lett; 2023 Jan; 597(1):92-101. PubMed ID: 36251330
    [TBL] [Abstract][Full Text] [Related]  

  • 6. ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S]
    Yang H; Ho MB; Lundahl MN; Mosquera MA; Broderick WE; Broderick JB; Hoffman BM
    J Am Chem Soc; 2024 Feb; 146(6):3710-3720. PubMed ID: 38308759
    [No Abstract]   [Full Text] [Related]  

  • 7. Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily.
    Hoffman BM; Broderick WE; Broderick JB
    Annu Rev Biochem; 2023 Jun; 92():333-349. PubMed ID: 37018846
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Auxiliary iron-sulfur cofactors in radical SAM enzymes.
    Lanz ND; Booker SJ
    Biochim Biophys Acta; 2015 Jun; 1853(6):1316-34. PubMed ID: 25597998
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an
    Yang H; Impano S; Shepard EM; James CD; Broderick WE; Broderick JB; Hoffman BM
    J Am Chem Soc; 2019 Oct; 141(40):16117-16124. PubMed ID: 31509404
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Radical SAM Enzyme Spore Photoproduct Lyase: Properties of the Ω Organometallic Intermediate and Identification of Stable Protein Radicals Formed during Substrate-Free Turnover.
    Pagnier A; Yang H; Jodts RJ; James CD; Shepard EM; Impano S; Broderick WE; Hoffman BM; Broderick JB
    J Am Chem Soc; 2020 Oct; 142(43):18652-18660. PubMed ID: 32966073
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis.
    Dong M; Horitani M; Dzikovski B; Freed JH; Ealick SE; Hoffman BM; Lin H
    J Am Chem Soc; 2017 Apr; 139(16):5680-5683. PubMed ID: 28383907
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Coordination and mechanism of reversible cleavage of S-adenosylmethionine by the [4Fe-4S] center in lysine 2,3-aminomutase.
    Chen D; Walsby C; Hoffman BM; Frey PA
    J Am Chem Soc; 2003 Oct; 125(39):11788-9. PubMed ID: 14505379
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural studies of the interaction of S-adenosylmethionine with the [4Fe-4S] clusters in biotin synthase and pyruvate formate-lyase activating enzyme.
    Cosper MM; Cosper NJ; Hong W; Shokes JE; Broderick WE; Broderick JB; Johnson MK; Scott RA
    Protein Sci; 2003 Jul; 12(7):1573-7. PubMed ID: 12824504
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Radical SAM catalysis via an organometallic intermediate with an Fe-[5'-C]-deoxyadenosyl bond.
    Horitani M; Shisler K; Broderick WE; Hutcheson RU; Duschene KS; Marts AR; Hoffman BM; Broderick JB
    Science; 2016 May; 352(6287):822-5. PubMed ID: 27174986
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pyruvate formate-lyase activating enzyme: The catalytically active 5'-deoxyadenosyl radical caught in the act of H-atom abstraction.
    Lundahl MN; Yang H; Broderick WE; Hoffman BM; Broderick JB
    Proc Natl Acad Sci U S A; 2023 Nov; 120(47):e2314696120. PubMed ID: 37956301
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase.
    Blaszczyk AJ; Silakov A; Zhang B; Maiocco SJ; Lanz ND; Kelly WL; Elliott SJ; Krebs C; Booker SJ
    J Am Chem Soc; 2016 Mar; 138(10):3416-26. PubMed ID: 26841310
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis.
    Byer AS; Yang H; McDaniel EC; Kathiresan V; Impano S; Pagnier A; Watts H; Denler C; Vagstad AL; Piel J; Duschene KS; Shepard EM; Shields TP; Scott LG; Lilla EA; Yokoyama K; Broderick WE; Hoffman BM; Broderick JB
    J Am Chem Soc; 2018 Jul; 140(28):8634-8638. PubMed ID: 29954180
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Reversible Formation of Alkyl Radicals at [Fe
    Brown AC; Suess DLM
    J Am Chem Soc; 2020 Aug; 142(33):14240-14248. PubMed ID: 32696642
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.
    Grove TL; Radle MI; Krebs C; Booker SJ
    J Am Chem Soc; 2011 Dec; 133(49):19586-9. PubMed ID: 21916495
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
    Dong M; Kathiresan V; Fenwick MK; Torelli AT; Zhang Y; Caranto JD; Dzikovski B; Sharma A; Lancaster KM; Freed JH; Ealick SE; Hoffman BM; Lin H
    Science; 2018 Mar; 359(6381):1247-1250. PubMed ID: 29590073
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.