BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

263 related articles for article (PubMed ID: 34718736)

  • 1. Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression.
    Li Y; Li J; Wang J; Lynch DR; Shen X; Corey DR; Parekh D; Bhat B; Woo C; Cherry JJ; Napierala JS; Napierala M
    Nucleic Acids Res; 2021 Nov; 49(20):11560-11574. PubMed ID: 34718736
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat.
    Li L; Shen X; Liu Z; Norrbom M; Prakash TP; O'Reilly D; Sharma VK; Damha MJ; Watts JK; Rigo F; Corey DR
    Nucleic Acid Ther; 2018 Feb; 28(1):23-33. PubMed ID: 29341839
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Premature transcription termination at the expanded GAA repeats and aberrant alternative polyadenylation contributes to the Frataxin transcriptional deficit in Friedreich's ataxia.
    Li Y; Li J; Wang J; Zhang S; Giles K; Prakash TP; Rigo F; Napierala JS; Napierala M
    Hum Mol Genet; 2022 Oct; 31(20):3539-3557. PubMed ID: 35708503
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Progress towards drug discovery for Friedreich's Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein.
    Shen X; Wong J; Prakash TP; Rigo F; Li Y; Napierala M; Corey DR
    Bioorg Med Chem; 2020 Jun; 28(11):115472. PubMed ID: 32279920
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A Comprehensive Transcriptome Analysis Identifies FXN and BDNF as Novel Targets of miRNAs in Friedreich's Ataxia Patients.
    Misiorek JO; Schreiber AM; Urbanek-Trzeciak MO; Jazurek-Ciesiołka M; Hauser LA; Lynch DR; Napierala JS; Napierala M
    Mol Neurobiol; 2020 Jun; 57(6):2639-2653. PubMed ID: 32291635
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.
    Lufino MM; Silva AM; Németh AH; Alegre-Abarrategui J; Russell AJ; Wade-Martins R
    Hum Mol Genet; 2013 Dec; 22(25):5173-87. PubMed ID: 23943791
    [TBL] [Abstract][Full Text] [Related]  

  • 7. G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects.
    Wang F; Calvo-Roitberg E; Rembetsy-Brown JM; Fang M; Sousa J; Kartje ZJ; Krishnamurthy PM; Lee J; Green MR; Pai AA; Watts JK
    Nucleic Acids Res; 2022 Dec; 50(22):12657-12673. PubMed ID: 36511872
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Difficulties translating antisense-mediated activation of Frataxin expression from cell culture to mice.
    Kilikevicius A; Wang J; Shen X; Rigo F; Prakash TP; Napierala M; Corey DR
    RNA Biol; 2022; 19(1):364-372. PubMed ID: 35289725
    [TBL] [Abstract][Full Text] [Related]  

  • 9. SINEUP non-coding RNAs rescue defective frataxin expression and activity in a cellular model of Friedreich's Ataxia.
    Bon C; Luffarelli R; Russo R; Fortuni S; Pierattini B; Santulli C; Fimiani C; Persichetti F; Cotella D; Mallamaci A; Santoro C; Carninci P; Espinoza S; Testi R; Zucchelli S; Condò I; Gustincich S
    Nucleic Acids Res; 2019 Nov; 47(20):10728-10743. PubMed ID: 31584077
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Expression of human frataxin is regulated by transcription factors SRF and TFAP2.
    Li K; Singh A; Crooks DR; Dai X; Cong Z; Pan L; Ha D; Rouault TA
    PLoS One; 2010 Aug; 5(8):e12286. PubMed ID: 20808827
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Efficient electroporation of neuronal cells using synthetic oligonucleotides: identifying duplex RNA and antisense oligonucleotide activators of human frataxin expression.
    Shen X; Beasley S; Putman JN; Li Y; Prakash TP; Rigo F; Napierala M; Corey DR
    RNA; 2019 Sep; 25(9):1118-1129. PubMed ID: 31151992
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming.
    Polak U; Li Y; Butler JS; Napierala M
    Stem Cells Dev; 2016 Dec; 25(23):1788-1800. PubMed ID: 27615158
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia.
    Kim E; Napierala M; Dent SY
    Nucleic Acids Res; 2011 Oct; 39(19):8366-77. PubMed ID: 21745819
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy.
    Li J; Li Y; Wang J; Gonzalez TJ; Asokan A; Napierala JS; Napierala M
    Hum Gene Ther; 2020 Aug; 31(15-16):839-851. PubMed ID: 32527155
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells.
    Silva AM; Brown JM; Buckle VJ; Wade-Martins R; Lufino MM
    Hum Mol Genet; 2015 Jun; 24(12):3457-71. PubMed ID: 25814655
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
    Vilema-Enríquez G; Quinlan R; Kilfeather P; Mazzone R; Saqlain S; Del Molino Del Barrio I; Donato A; Corda G; Li F; Vedadi M; Németh AH; Brennan PE; Wade-Martins R
    J Biol Chem; 2020 Dec; 295(52):17973-17985. PubMed ID: 33028632
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblasts.
    Khonsari H; Schneider M; Al-Mahdawi S; Chianea YG; Themis M; Parris C; Pook MA; Themis M
    Gene Ther; 2016 Dec; 23(12):846-856. PubMed ID: 27518705
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion.
    Shen X; Kilikevicius A; O'Reilly D; Prakash TP; Damha MJ; Rigo F; Corey DR
    Bioorg Med Chem Lett; 2018 Sep; 28(17):2850-2855. PubMed ID: 30076049
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Genetic variations creating microRNA target sites in the FXN 3'-UTR affect frataxin expression in Friedreich ataxia.
    Bandiera S; Cartault F; Jannot AS; Hatem E; Girard M; Rifai L; Loiseau C; Munnich A; Lyonnet S; Henrion-Caude A
    PLoS One; 2013; 8(1):e54791. PubMed ID: 23382970
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Posttranslational regulation of mitochondrial frataxin and identification of compounds that increase frataxin levels in Friedreich's ataxia.
    Hackett PT; Jia X; Li L; Ward DM
    J Biol Chem; 2022 Jun; 298(6):101982. PubMed ID: 35472330
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.