These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

237 related articles for article (PubMed ID: 34725156)

  • 1. Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation.
    Liu X; Yang S; Hart JR; Xu Y; Zou X; Zhang H; Zhou Q; Xia T; Zhang Y; Yang D; Wang MW; Vogt PK
    Proc Natl Acad Sci U S A; 2021 Nov; 118(45):. PubMed ID: 34725156
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Kα).
    Vogt PK; Hart JR; Yang S; Zhou Q; Yang D; Wang MW
    Biochim Biophys Acta Rev Cancer; 2023 Sep; 1878(5):188947. PubMed ID: 37394020
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα.
    Liu X; Zhou Q; Hart JR; Xu Y; Yang S; Yang D; Vogt PK; Wang MW
    Proc Natl Acad Sci U S A; 2022 Nov; 119(46):e2215621119. PubMed ID: 36343266
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα.
    Hart JR; Liu X; Pan C; Liang A; Ueno L; Xu Y; Quezada A; Zou X; Yang S; Zhou Q; Schoonooghe S; Hassanzadeh-Ghassabeh G; Xia T; Shui W; Yang D; Vogt PK; Wang MW
    Proc Natl Acad Sci U S A; 2022 Sep; 119(38):e2210769119. PubMed ID: 36095215
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases.
    Hon WC; Berndt A; Williams RL
    Oncogene; 2012 Aug; 31(32):3655-66. PubMed ID: 22120714
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cryo-EM structures reveal two allosteric inhibition modes of PI3Kα
    Huang X; Wang K; Han J; Chen X; Wang Z; Wu T; Yu B; Zhao F; Wang X; Li H; Xie Z; Zhu X; Zhong W; Ren X
    Structure; 2024 Jul; 32(7):907-917.e7. PubMed ID: 38582077
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.
    Pirola L; Zvelebil MJ; Bulgarelli-Leva G; Van Obberghen E; Waterfield MD; Wymann MP
    J Biol Chem; 2001 Jun; 276(24):21544-54. PubMed ID: 11278889
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural insights into the activation mechanism of phosphoinositide 3-kinase alpha.
    Jani V; Sonavane U; Sawant S
    Comput Biol Chem; 2024 Feb; 108():107994. PubMed ID: 38043374
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design.
    Chen P; Deng YL; Bergqvist S; Falk MD; Liu W; Timofeevski S; Brooun A
    Protein Sci; 2014 Oct; 23(10):1332-40. PubMed ID: 25043846
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural insights into the interaction of three Y-shaped ligands with PI3Kα.
    Zhou Q; Liu X; Neri D; Li W; Favalli N; Bassi G; Yang S; Yang D; Vogt PK; Wang MW
    Proc Natl Acad Sci U S A; 2023 Aug; 120(34):e2304071120. PubMed ID: 37585458
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Double
    Vasan N; Razavi P; Johnson JL; Shao H; Shah H; Antoine A; Ladewig E; Gorelick A; Lin TY; Toska E; Xu G; Kazmi A; Chang MT; Taylor BS; Dickler MN; Jhaveri K; Chandarlapaty S; Rabadan R; Reznik E; Smith ML; Sebra R; Schimmoller F; Wilson TR; Friedman LS; Cantley LC; Scaltriti M; Baselga J
    Science; 2019 Nov; 366(6466):714-723. PubMed ID: 31699932
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis of nSH2 regulation and lipid binding in PI3Kα.
    Miller MS; Schmidt-Kittler O; Bolduc DM; Brower ET; Chaves-Moreira D; Allaire M; Kinzler KW; Jennings IG; Thompson PE; Cole PA; Amzel LM; Vogelstein B; Gabelli SB
    Oncotarget; 2014 Jul; 5(14):5198-208. PubMed ID: 25105564
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects.
    Gabelli SB; Echeverria I; Alexander M; Duong-Ly KC; Chaves-Moreira D; Brower ET; Vogelstein B; Amzel LM
    Biophys Rev; 2014 Mar; 6(1):89-95. PubMed ID: 25309634
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains.
    Yu J; Wjasow C; Backer JM
    J Biol Chem; 1998 Nov; 273(46):30199-203. PubMed ID: 9804776
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Definition of the binding mode of phosphoinositide 3-kinase α-selective inhibitor A-66S through molecular dynamics simulation.
    Bian X; Dong W; Zhao Y; Sun R; Kong W; Li Y
    J Mol Model; 2014 Apr; 20(4):2166. PubMed ID: 24633771
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α.
    Zhang M; Li Z; Wang G; Jang H; Sacks DB; Zhang J; Gaponenko V; Nussinov R
    J Phys Chem B; 2018 Dec; 122(49):11137-11146. PubMed ID: 30047727
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.
    Burke JE; Vadas O; Berndt A; Finegan T; Perisic O; Williams RL
    Structure; 2011 Aug; 19(8):1127-37. PubMed ID: 21827948
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition.
    Maheshwari S; Miller MS; O'Meally R; Cole RN; Amzel LM; Gabelli SB
    J Biol Chem; 2017 Aug; 292(33):13541-13550. PubMed ID: 28676499
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases.
    Dornan GL; Stariha JTB; Rathinaswamy MK; Powell CJ; Boulanger MJ; Burke JE
    Structure; 2020 Feb; 28(2):145-156.e5. PubMed ID: 31831213
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A deep learning-based theoretical protocol to identify potentially isoform-selective PI3Kα inhibitors.
    Shafiq M; Sherwani ZA; Mushtaq M; Nur-E-Alam M; Ahmad A; Ul-Haq Z
    Mol Divers; 2024 Aug; 28(4):1907-1924. PubMed ID: 38305819
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.