BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

225 related articles for article (PubMed ID: 34729310)

  • 1. Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3.
    Lu T; Li Y; Lu W; Spitters T; Fang X; Wang J; Cai S; Gao J; Zhou Y; Duan Z; Xiong H; Liu L; Li Q; Jiang H; Chen K; Zhou H; Lin H; Feng H; Zhou B; Antos CL; Luo C
    Acta Pharm Sin B; 2021 Oct; 11(10):3206-3219. PubMed ID: 34729310
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors.
    Lu W; Fan M; Ji W; Tse J; You I; Ficarro SB; Tavares I; Che J; Kim AY; Zhu X; Boghossian A; Rees MG; Ronan MM; Roth JA; Hinshaw SM; Nabet B; Corsello SM; Kwiatkowski N; Marto JA; Zhang T; Gray NS
    J Med Chem; 2023 Apr; 66(7):4617-4632. PubMed ID: 36946421
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Leveraging the Fragment Molecular Orbital and MM-GBSA Methods in Virtual Screening for the Discovery of Novel Non-Covalent Inhibitors Targeting the TEAD Lipid Binding Pocket.
    Kim J; Jin H; Kim J; Cho SY; Moon S; Wang J; Mao J; No KT
    Int J Mol Sci; 2024 May; 25(10):. PubMed ID: 38791396
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode.
    Hu L; Sun Y; Liu S; Erb H; Singh A; Mao J; Luo X; Wu X
    Elife; 2022 Nov; 11():. PubMed ID: 36398861
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors.
    Sturbaut M; Bailly F; Coevoet M; Sileo P; Pugniere M; Liberelle M; Magnez R; Thuru X; Chartier-Harlin MC; Melnyk P; Gelin M; Allemand F; Guichou JF; Cotelle P
    Eur J Med Chem; 2021 Dec; 226():113835. PubMed ID: 34509860
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling.
    Fan M; Lu W; Che J; Kwiatkowski NP; Gao Y; Seo HS; Ficarro SB; Gokhale PC; Liu Y; Geffken EA; Lakhani J; Song K; Kuljanin M; Ji W; Jiang J; He Z; Tse J; Boghossian AS; Rees MG; Ronan MM; Roth JA; Mancias JD; Marto JA; Dhe-Paganon S; Zhang T; Gray NS
    Elife; 2022 Oct; 11():. PubMed ID: 36300789
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Toward the Design of Ligands Selective for the C-Terminal Domain of TEADs.
    Liberelle M; Toulotte F; Renault N; Gelin M; Allemand F; Melnyk P; Guichou JF; Cotelle P
    J Med Chem; 2022 Apr; 65(8):5926-5940. PubMed ID: 35389210
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma.
    Kaneda A; Seike T; Danjo T; Nakajima T; Otsubo N; Yamaguchi D; Tsuji Y; Hamaguchi K; Yasunaga M; Nishiya Y; Suzuki M; Saito JI; Yatsunami R; Nakamura S; Sekido Y; Mori K
    Am J Cancer Res; 2020; 10(12):4399-4415. PubMed ID: 33415007
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hippo pathway inhibition by blocking the YAP/TAZ-TEAD interface: a patent review.
    Crawford JJ; Bronner SM; Zbieg JR
    Expert Opin Ther Pat; 2018 Dec; 28(12):867-873. PubMed ID: 30482112
    [No Abstract]   [Full Text] [Related]  

  • 10. The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity.
    Shimomura T; Miyamura N; Hata S; Miura R; Hirayama J; Nishina H
    Biochem Biophys Res Commun; 2014 Jan; 443(3):917-23. PubMed ID: 24380865
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway.
    Miesfeld JB; Link BA
    Mech Dev; 2014 Aug; 133():177-88. PubMed ID: 24560909
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Progress with YAP/TAZ-TEAD inhibitors: a patent review (2018-present).
    Zagiel B; Melnyk P; Cotelle P
    Expert Opin Ther Pat; 2022 Aug; 32(8):899-912. PubMed ID: 35768160
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors.
    Lu W; Wang J; Li Y; Tao H; Xiong H; Lian F; Gao J; Ma H; Lu T; Zhang D; Ye X; Ding H; Yue L; Zhang Y; Tang H; Zhang N; Yang Y; Jiang H; Chen K; Zhou B; Luo C
    Eur J Med Chem; 2019 Dec; 184():111767. PubMed ID: 31622854
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.
    Noland CL; Gierke S; Schnier PD; Murray J; Sandoval WN; Sagolla M; Dey A; Hannoush RN; Fairbrother WJ; Cunningham CN
    Structure; 2016 Jan; 24(1):179-186. PubMed ID: 26724994
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Therapeutic targeting of TEAD transcription factors in cancer.
    Pobbati AV; Kumar R; Rubin BP; Hong W
    Trends Biochem Sci; 2023 May; 48(5):450-462. PubMed ID: 36709077
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of Quinolinols as Activators of TEAD-Dependent Transcription.
    Pobbati AV; Mejuch T; Chakraborty S; Karatas H; Bharath SR; Guéret SM; Goy PA; Hahne G; Pahl A; Sievers S; Guccione E; Song H; Waldmann H; Hong W
    ACS Chem Biol; 2019 Dec; 14(12):2909-2921. PubMed ID: 31742995
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activity.
    Gridnev A; Maity S; Misra JR
    Front Oncol; 2022; 12():1021823. PubMed ID: 36523977
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effect of the acylation of TEAD4 on its interaction with co-activators YAP and TAZ.
    Mesrouze Y; Meyerhofer M; Bokhovchuk F; Fontana P; Zimmermann C; Martin T; Delaunay C; Izaac A; Kallen J; Schmelzle T; Erdmann D; Chène P
    Protein Sci; 2017 Dec; 26(12):2399-2409. PubMed ID: 28960584
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD·YAP1 interaction.
    Bum-Erdene K; Ghozayel MK; Zhang MJ; Gonzalez-Gutierrez G; Meroueh SO
    RSC Med Chem; 2023 Sep; 14(9):1803-1816. PubMed ID: 37731696
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists.
    Bum-Erdene K; Yeh IJ; Gonzalez-Gutierrez G; Ghozayel MK; Pollok K; Meroueh SO
    J Med Chem; 2023 Jan; 66(1):266-284. PubMed ID: 36562717
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.