181 related articles for article (PubMed ID: 34754068)
1. Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins.
Malvezzi F; Stubbs CJ; Jowitt TA; Dale IL; Guo X; DeGnore JP; Degliesposti G; Skehel JM; Bannister AJ; McAlister MS
Commun Biol; 2021 Nov; 4(1):1273. PubMed ID: 34754068
[TBL] [Abstract][Full Text] [Related]
2. Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting.
Wu SY; Lee AY; Lai HT; Zhang H; Chiang CM
Mol Cell; 2013 Mar; 49(5):843-57. PubMed ID: 23317504
[TBL] [Abstract][Full Text] [Related]
3. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.
Shu S; Lin CY; He HH; Witwicki RM; Tabassum DP; Roberts JM; Janiszewska M; Huh SJ; Liang Y; Ryan J; Doherty E; Mohammed H; Guo H; Stover DG; Ekram MB; Brown J; D'Santos C; Krop IE; Dillon D; McKeown M; Ott C; Qi J; Ni M; Rao PK; Duarte M; Wu SY; Chiang CM; Anders L; Young RA; Winer E; Letai A; Barry WT; Carroll JS; Long H; Brown M; Liu XS; Meyer CA; Bradner JE; Polyak K
Nature; 2016 Jan; 529(7586):413-417. PubMed ID: 26735014
[TBL] [Abstract][Full Text] [Related]
4. Involvement of Brd4 in different steps of the papillomavirus life cycle.
Iftner T; Haedicke-Jarboui J; Wu SY; Chiang CM
Virus Res; 2017 Mar; 231():76-82. PubMed ID: 27965149
[TBL] [Abstract][Full Text] [Related]
5. Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation.
Zheng B; Gold S; Iwanaszko M; Howard BC; Wang L; Shilatifard A
Mol Cell; 2023 Aug; 83(16):2896-2910.e4. PubMed ID: 37442129
[TBL] [Abstract][Full Text] [Related]
6. Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.
Werner MT; Wang H; Hamagami N; Hsu SC; Yano JA; Stonestrom AJ; Behera V; Zong Y; Mackay JP; Blobel GA
J Biol Chem; 2020 Feb; 295(7):1898-1914. PubMed ID: 31792058
[TBL] [Abstract][Full Text] [Related]
7. Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Wang W; Tang YA; Xiao Q; Lee WC; Cheng B; Niu Z; Oguz G; Feng M; Lee PL; Li B; Yang ZH; Chen YF; Lan P; Wu XJ; Yu Q
Nat Commun; 2021 Jul; 12(1):4441. PubMed ID: 34290255
[TBL] [Abstract][Full Text] [Related]
8. Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites.
Olp MD; Sprague DJ; Goetz CJ; Kathman SG; Wynia-Smith SL; Shishodia S; Summers SB; Xu Z; Statsyuk AV; Smith BC
ACS Chem Biol; 2020 Apr; 15(4):1036-1049. PubMed ID: 32149490
[TBL] [Abstract][Full Text] [Related]
9. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Faivre EJ; McDaniel KF; Albert DH; Mantena SR; Plotnik JP; Wilcox D; Zhang L; Bui MH; Sheppard GS; Wang L; Sehgal V; Lin X; Huang X; Lu X; Uziel T; Hessler P; Lam LT; Bellin RJ; Mehta G; Fidanze S; Pratt JK; Liu D; Hasvold LA; Sun C; Panchal SC; Nicolette JJ; Fossey SL; Park CH; Longenecker K; Bigelow L; Torrent M; Rosenberg SH; Kati WM; Shen Y
Nature; 2020 Feb; 578(7794):306-310. PubMed ID: 31969702
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation.
Li X; Yang Q; Jiang P; Wen J; Chen Y; Huang J; Tian M; Ren J; Yang Q
Neurochem Res; 2024 May; 49(5):1254-1267. PubMed ID: 38381246
[TBL] [Abstract][Full Text] [Related]
11. Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
Guan X; Cheryala N; Karim RM; Chan A; Berndt N; Qi J; Georg GI; Schönbrunn E
J Med Chem; 2022 Aug; 65(15):10441-10458. PubMed ID: 35867655
[TBL] [Abstract][Full Text] [Related]
12. IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors.
Wu SY; Lai HT; Sanjib Banerjee N; Ma Z; Santana JF; Wei S; Liu X; Zhang M; Zhan J; Chen H; Posner B; Chen Y; Price DH; Chow LT; Zhou J; Chiang CM
Mol Cell; 2024 Jan; 84(2):202-220.e15. PubMed ID: 38103559
[TBL] [Abstract][Full Text] [Related]
13. BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity.
Khoueiry P; Ward Gahlawat A; Petretich M; Michon AM; Simola D; Lam E; Furlong EE; Benes V; Dawson MA; Prinjha RK; Drewes G; Grandi P
Epigenetics Chromatin; 2019 Jul; 12(1):39. PubMed ID: 31266503
[TBL] [Abstract][Full Text] [Related]
14. The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains.
Weissman JD; Singh AK; Devaiah BN; Schuck P; LaRue RC; Singer DS
J Biol Chem; 2021 Nov; 297(5):101326. PubMed ID: 34688663
[TBL] [Abstract][Full Text] [Related]
15. Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy.
Zhang J; Tang P; Zou L; Zhang J; Chen J; Yang C; He G; Liu B; Liu J; Chiang CM; Wang G; Ye T; Ouyang L
J Med Chem; 2021 Dec; 64(24):18025-18053. PubMed ID: 34908415
[TBL] [Abstract][Full Text] [Related]
16. Co-targeting BET bromodomain BRD4 and RAC1 suppresses growth, stemness and tumorigenesis by disrupting the c-MYC-G9a-FTH1axis and downregulating HDAC1 in molecular subtypes of breast cancer.
Ali A; Shafarin J; Unnikannan H; Al-Jabi N; Jabal RA; Bajbouj K; Muhammad JS; Hamad M
Int J Biol Sci; 2021; 17(15):4474-4492. PubMed ID: 34803511
[TBL] [Abstract][Full Text] [Related]
17.
Nord JA; Wynia-Smith SL; Gehant AL; Jones Lipinski RA; Naatz A; Rioja I; Prinjha RK; Corbett JA; Smith BC
Front Endocrinol (Lausanne); 2022; 13():923925. PubMed ID: 36176467
[TBL] [Abstract][Full Text] [Related]
18. Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure.
Wang R; Li Q; Helfer CM; Jiao J; You J
J Biol Chem; 2012 Mar; 287(14):10738-52. PubMed ID: 22334664
[TBL] [Abstract][Full Text] [Related]
19. Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation-Serial Fragmentation (PASEF) Mass Spectrometry.
Mann M; Roberts DS; Zhu Y; Li Y; Zhou J; Ge Y; Brasier AR
Viruses; 2021 Mar; 13(3):. PubMed ID: 33799525
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of BET Family Proteins Suppresses African Swine Fever Virus Infection.
Zhao Y; Niu Q; Yang S; Yang J; Zhang Z; Geng S; Fan J; Liu Z; Guan G; Liu Z; Zhou J; Hu H; Luo J; Yin H
Microbiol Spectr; 2022 Aug; 10(4):e0241921. PubMed ID: 35758684
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
