BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

161 related articles for article (PubMed ID: 34767913)

  • 1. Discovery of aryl aminothiazole γ-secretase modulators with novel effects on amyloid β-peptide production.
    Bhattarai S; Liu L; Wolfe MS
    Bioorg Med Chem Lett; 2021 Dec; 54():128446. PubMed ID: 34767913
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
    Wagner SL; Zhang C; Cheng S; Nguyen P; Zhang X; Rynearson KD; Wang R; Li Y; Sisodia SS; Mobley WC; Tanzi RE
    Biochemistry; 2014 Feb; 53(4):702-13. PubMed ID: 24401146
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
    Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
    Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues.
    Devkota S; Williams TD; Wolfe MS
    J Biol Chem; 2021; 296():100281. PubMed ID: 33450230
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
    Czirr E; Cottrell BA; Leuchtenberger S; Kukar T; Ladd TB; Esselmann H; Paul S; Schubenel R; Torpey JW; Pietrzik CU; Golde TE; Wiltfang J; Baumann K; Koo EH; Weggen S
    J Biol Chem; 2008 Jun; 283(25):17049-54. PubMed ID: 18426795
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.
    Fernandez MA; Klutkowski JA; Freret T; Wolfe MS
    J Biol Chem; 2014 Nov; 289(45):31043-52. PubMed ID: 25239621
    [TBL] [Abstract][Full Text] [Related]  

  • 7. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
    Scannevin RH; Chollate S; Brennan MS; Snodgrass-Belt PA; Peng H; Xu L; Jung MY; Bussiere T; Arastu MF; Talreja T; Xin Z; Dunstan RW; Fahrer D; Rohde E; Dunah AW; Wang J; Kumaravel G; Taveras AG; Moore Arnold H; Rhodes KJ
    Neuropharmacology; 2016 Apr; 103():57-68. PubMed ID: 26690893
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
    Blain JF; Bursavich MG; Freeman EA; Hrdlicka LA; Hodgdon HE; Chen T; Costa DE; Harrison BA; Kapadnis S; Murphy DA; Nolan S; Tu Z; Tang C; Burnett DA; Patzke H; Koenig G
    Alzheimers Res Ther; 2016 Aug; 8(1):34. PubMed ID: 27572246
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aminothiazoles as γ-secretase modulators.
    Lübbers T; Flohr A; Jolidon S; David-Pierson P; Jacobsen H; Ozmen L; Baumann K
    Bioorg Med Chem Lett; 2011 Nov; 21(21):6554-8. PubMed ID: 21924610
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
    Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
    J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase.
    Jung CG; Uhm KO; Horike H; Kim MJ; Misumi S; Ishida A; Ueda Y; Choi EK; Kim YS; Michikawa M; Hida H
    J Alzheimers Dis; 2015; 43(4):1215-28. PubMed ID: 25147119
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.
    Rynearson KD; Buckle RN; Barnes KD; Herr RJ; Mayhew NJ; Paquette WD; Sakwa SA; Nguyen PD; Johnson G; Tanzi RE; Wagner SL
    Bioorg Med Chem Lett; 2016 Aug; 26(16):3928-37. PubMed ID: 27426299
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.
    Strömberg K; Eketjäll S; Georgievska B; Tunblad K; Eliason K; Olsson F; Radesäter AC; Klintenberg R; Arvidsson PI; von Berg S; Fälting J; Cowburn RF; Dabrowski M
    FEBS J; 2015 Jan; 282(1):65-73. PubMed ID: 25303711
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.
    Rogers K; Felsenstein KM; Hrdlicka L; Tu Z; Albayya F; Lee W; Hopp S; Miller MJ; Spaulding D; Yang Z; Hodgdon H; Nolan S; Wen M; Costa D; Blain JF; Freeman E; De Strooper B; Vulsteke V; Scrocchi L; Zetterberg H; Portelius E; Hutter-Paier B; Havas D; Ahlijanian M; Flood D; Leventhal L; Shapiro G; Patzke H; Chesworth R; Koenig G
    Mol Neurodegener; 2012 Dec; 7():61. PubMed ID: 23249765
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and synthesis of an aminopiperidine series of γ-secretase modulators.
    Kobayashi T; Iwama S; Fusano A; Kato Y; Ikeda A; Teranishi Y; Nishihara A; Tobe M
    Bioorg Med Chem Lett; 2014 Jan; 24(1):378-81. PubMed ID: 24269163
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pharmacological and Toxicological Properties of the Potent Oral
    Wagner SL; Rynearson KD; Duddy SK; Zhang C; Nguyen PD; Becker A; Vo U; Masliah D; Monte L; Klee JB; Echmalian CM; Xia W; Quinti L; Johnson G; Lin JH; Kim DY; Mobley WC; Rissman RA; Tanzi RE
    J Pharmacol Exp Ther; 2017 Jul; 362(1):31-44. PubMed ID: 28416568
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.
    Gay M; Evrard C; Descamps F; Carato P; Renault N; Coevoet M; Eddarkaoui S; Baud C; Larchanché PE; Buée L; El Bakali J; Vingtdeux V; Sergeant N; Melnyk P
    Eur J Med Chem; 2018 Nov; 159():104-125. PubMed ID: 30268822
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides.
    Cam M; Durieu E; Bodin M; Manousopoulou A; Koslowski S; Vasylieva N; Barnych B; Hammock BD; Bohl B; Koch P; Omori C; Yamamoto K; Hata S; Suzuki T; Karg F; Gizzi P; Erakovic Haber V; Bencetic Mihaljevic V; Tavcar B; Portelius E; Pannee J; Blennow K; Zetterberg H; Garbis SD; Auvray P; Gerber H; Fraering J; Fraering PC; Meijer L
    J Alzheimers Dis; 2018; 62(4):1663-1681. PubMed ID: 29504531
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease.
    Svedružić ZM; Popović K; Smoljan I; Sendula-Jengić V
    PLoS One; 2012; 7(3):e32293. PubMed ID: 22479317
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Generation and Partial Characterization of Rabbit Monoclonal Antibody to Amyloid-β Peptide 1-37 (Aβ37).
    Mehta PD; Blain JF; Freeman EA; Patrick BA; Barshatzky M; Hrdlicka LA; Mehta SP; Frackowiak J; Mazur-Kolecka B; Wegiel J; Patzke H; Miller DL
    J Alzheimers Dis; 2017; 57(1):135-145. PubMed ID: 28222530
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.