BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

254 related articles for article (PubMed ID: 34770990)

  • 1. Pyrrolizine/Indolizine-NSAID Hybrids: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies.
    Abourehab MAS; Alqahtani AM; Almalki FA; Zaher DM; Abdalla AN; Gouda AM; Beshr EAM
    Molecules; 2021 Oct; 26(21):. PubMed ID: 34770990
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities.
    Attalah KM; Abdalla AN; Aslam A; Ahmed M; Abourehab MAS; ElSawy NA; Gouda AM
    Bioorg Chem; 2020 Jan; 94():103371. PubMed ID: 31708230
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases.
    Almalki FA; Abdalla AN; Shawky AM; El Hassab MA; Gouda AM
    Molecules; 2021 Jun; 26(13):. PubMed ID: 34209011
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of new pyrimidopyrrolizine/indolizine-based derivatives as P-glycoprotein inhibitors: Design, synthesis, cytotoxicity, and MDR reversal activities.
    Shawky AM; Abdalla AN; Ibrahim NA; Abourehab MAS; Gouda AM
    Eur J Med Chem; 2021 Jun; 218():113403. PubMed ID: 33823396
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities.
    Gouda AM; Abdelazeem AH; Abdalla AN; Ahmed M
    Acta Pharm; 2018 Sep; 68(3):251-273. PubMed ID: 31259695
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency.
    Shawky AM; Abourehab MAS; Abdalla AN; Gouda AM
    Eur J Med Chem; 2020 Jan; 185():111780. PubMed ID: 31655429
    [TBL] [Abstract][Full Text] [Related]  

  • 7. New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies.
    Fadaly WAA; Elshaier YAMM; Hassanein EHM; Abdellatif KRA
    Bioorg Chem; 2020 May; 98():103752. PubMed ID: 32197148
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities.
    Shawky AM; Ibrahim NA; Abourehab MAS; Abdalla AN; Gouda AM
    J Enzyme Inhib Med Chem; 2021 Dec; 36(1):15-33. PubMed ID: 33103497
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Curcumin Conjugates of Non-steroidal Anti-Inflammatory Drugs: Synthesis, Structures, Anti-proliferative Assays, Computational Docking, and Inflammatory Response.
    Laali KK; Zwarycz AT; Beck N; Borosky GL; Nukaya M; Kennedy GD
    ChemistryOpen; 2020 Aug; 9(8):822-834. PubMed ID: 32802728
    [TBL] [Abstract][Full Text] [Related]  

  • 10. New thiazol-hydrazono-coumarin hybrids targeting human cervical cancer cells: Synthesis, CDK2 inhibition, QSAR and molecular docking studies.
    Abd El-Karim SS; Syam YM; El Kerdawy AM; Abdelghany TM
    Bioorg Chem; 2019 May; 86():80-96. PubMed ID: 30685646
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies.
    El-Azab AS; Abdel-Aziz AA; Abou-Zeid LA; El-Husseiny WM; El Morsy AM; El-Gendy MA; El-Sayed MA
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):989-998. PubMed ID: 29806488
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antitumor activity of pyrrolizines and their Cu(II) complexes: Design, synthesis and cytotoxic screening with potential apoptosis-inducing activity.
    Gouda AM; El-Ghamry HA; Bawazeer TM; Farghaly TA; Abdalla AN; Aslam A
    Eur J Med Chem; 2018 Feb; 145():350-359. PubMed ID: 29335201
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Biological evaluation of indolizine-chalcone hybrids as new anticancer agents.
    Park S; Kim EH; Kim J; Kim SH; Kim I
    Eur J Med Chem; 2018 Jan; 144():435-443. PubMed ID: 29288944
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells.
    Alam MM; Malebari AM; Syed N; Neamatallah T; Almalki ASA; Elhenawy AA; Obaid RJ; Alsharif MA
    Bioorg Med Chem; 2021 May; 38():116136. PubMed ID: 33894490
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Biological Activity, Apoptotic Induction and Cell Cycle Arrest of New Hydrazonoyl Halides Derivatives.
    Mohamed MF; Hassaneen HM; Elzayat EM; El-Hallouty SM; El-Manawaty M; Saleh FM; Mohamed Y; El-Zohiry D; Fahmy G; Abdelaal N; Hassanin N; Hossam N
    Anticancer Agents Med Chem; 2019; 19(9):1141-1149. PubMed ID: 30843494
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and
    Eldehna WM; Al-Rashood ST; Al-Warhi T; Eskandrani RO; Alharbi A; El Kerdawy AM
    J Enzyme Inhib Med Chem; 2021 Dec; 36(1):270-285. PubMed ID: 33327806
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action.
    Gouda AM; Abdelazeem AH; Omar HA; Abdalla AN; Abourehab MAS; Ali HI
    Bioorg Med Chem; 2017 Oct; 25(20):5637-5651. PubMed ID: 28916158
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity.
    Moise IM; Bîcu E; Farce A; Dubois J; Ghinet A
    Bioorg Chem; 2020 Oct; 103():104184. PubMed ID: 32891861
    [TBL] [Abstract][Full Text] [Related]  

  • 19. EGFR/VEGFR-2 dual inhibitor and apoptotic inducer: Design, synthesis, anticancer activity and docking study of new 2-thioxoimidazolidin-4one derivatives.
    Mourad AAE; Farouk NA; El-Sayed EH; Mahdy ARE
    Life Sci; 2021 Jul; 277():119531. PubMed ID: 33887348
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular docking studies, biological evaluation and synthesis of novel 3-mercapto-1,2,4-triazole derivatives.
    Ghanaat J; Khalilzadeh MA; Zareyee D
    Mol Divers; 2021 Feb; 25(1):223-232. PubMed ID: 32067134
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.