BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 34783037)

  • 1. Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption.
    Essandoh K; Auchus RJ; Brody MJ
    J Pathol; 2022 Mar; 256(3):249-252. PubMed ID: 34783037
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure.
    Xu N; Guan S; Chen Z; Yu Y; Xie J; Pan FY; Zhao NW; Liu L; Yang ZZ; Gao X; Xu B; Li CJ
    J Pathol; 2015 Apr; 235(5):672-85. PubMed ID: 25385233
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Key Enzymes for the Mevalonate Pathway in the Cardiovascular System.
    Zhang C; Jin DD; Wang XY; Lou L; Yang J
    J Cardiovasc Pharmacol; 2021 Feb; 77(2):142-152. PubMed ID: 33538531
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cardiac-specific deletion of FDPS induces cardiac remodeling and dysfunction by enhancing the activity of small GTP-binding proteins.
    Wang X; Zhang X; Chen Y; Zhao C; Zhou W; Chen W; Zhang C; Ding K; Li W; Xu H; Lou L; Chu Z; Hu S; Yang J
    J Pathol; 2021 Dec; 255(4):438-450. PubMed ID: 34467534
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation of Small GTPase Prenylation in the Nervous System.
    Reddy JM; Raut NGR; Seifert JL; Hynds DL
    Mol Neurobiol; 2020 May; 57(5):2220-2231. PubMed ID: 31989383
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.
    Basso AD; Mirza A; Liu G; Long BJ; Bishop WR; Kirschmeier P
    J Biol Chem; 2005 Sep; 280(35):31101-8. PubMed ID: 16006564
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
    Yang J; Mou Y; Wu T; Ye Y; Jiang JC; Zhao CZ; Zhu HH; Du CQ; Zhou L; Hu SJ
    Cardiovasc Res; 2013 Mar; 97(3):490-9. PubMed ID: 23180723
    [TBL] [Abstract][Full Text] [Related]  

  • 8. High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway.
    Mather A; Chen XM; McGinn S; Field MJ; Sumual S; Mangiafico S; Zhang Y; Kelly DJ; Pollock CA
    Int J Biochem Cell Biol; 2009 Mar; 41(3):561-9. PubMed ID: 18692592
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases.
    García-Torres D; Fierke CA
    J Biol Chem; 2019 Aug; 294(31):11793-11804. PubMed ID: 31197034
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.
    Hanker AB; Mitin N; Wilder RS; Henske EP; Tamanoi F; Cox AD; Der CJ
    Oncogene; 2010 Jan; 29(3):380-91. PubMed ID: 19838215
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodeling.
    Zhao CZ; Zhao XM; Yang J; Mou Y; Chen B; Wu HD; Dai DP; Ding J; Hu SJ
    Sci Rep; 2016 Dec; 6():39186. PubMed ID: 28008986
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.
    Schuld NJ; Vervacke JS; Lorimer EL; Simon NC; Hauser AD; Barbieri JT; Distefano MD; Williams CL
    J Biol Chem; 2014 Mar; 289(10):6862-6876. PubMed ID: 24415755
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.
    Gbelcová H; Rimpelová S; Knejzlík Z; Šáchová J; Kolář M; Strnad H; Repiská V; D'Acunto WC; Ruml T; Vítek L
    Lipids Health Dis; 2017 Dec; 16(1):250. PubMed ID: 29262834
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases.
    Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JM; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ
    Immunol Cell Biol; 2016 Nov; 94(10):994-999. PubMed ID: 27377765
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Splice variants of SmgGDS control small GTPase prenylation and membrane localization.
    Berg TJ; Gastonguay AJ; Lorimer EL; Kuhnmuench JR; Li R; Fields AP; Williams CL
    J Biol Chem; 2010 Nov; 285(46):35255-66. PubMed ID: 20709748
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of the mevalonate pathway ameliorates anoxia-induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells.
    Yang Y; Lu X; Rong X; Jiang W; Lai D; Ma Y; Zhou K; Fu G; Xu S
    J Mol Cell Cardiol; 2015 Mar; 80():166-74. PubMed ID: 25636197
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Insights into the mevalonate pathway in the anticancer effect of a platinum complex on human gastric cancer cells.
    Qiu L; Yang H; Lv G; Li K; Liu G; Wang W; Wang S; Zhao X; Xie M; Lin J
    Eur J Pharmacol; 2017 Sep; 810():120-127. PubMed ID: 28666798
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS.
    Henneman L; van Cruchten AG; Kulik W; Waterham HR
    Biochim Biophys Acta; 2011 Apr; 1811(4):227-33. PubMed ID: 21237288
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.
    Dunford JE; Rogers MJ; Ebetino FH; Phipps RJ; Coxon FP
    J Bone Miner Res; 2006 May; 21(5):684-94. PubMed ID: 16734383
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of mevalonate pathway prevents ischemia-induced cardiac dysfunction in rats via RhoA-independent signaling pathway.
    Yang Y; Rong X; Lv X; Jiang W; Yang Y; Lai D; Xu S; Fu G
    Cardiovasc Ther; 2017 Oct; 35(5):. PubMed ID: 28665545
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.