141 related articles for article (PubMed ID: 34788776)
1. Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia.
Cheng W; Li S; Wen X; Han S; Wang S; Wei H; Song Z; Wang Y; Tian X; Zhang X
Chem Commun (Camb); 2021 Nov; 57(95):12852-12855. PubMed ID: 34788776
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis and biological evaluation of the tumor hypoxia-activated PROTACs bearing caged CRBN E3 ligase ligands.
Cheng W; Li S; Han S; Miao R; Wang S; Liu C; Wei H; Tian X; Zhang X
Bioorg Med Chem; 2023 Mar; 82():117237. PubMed ID: 36906965
[TBL] [Abstract][Full Text] [Related]
3. Effective degradation of EGFR
Qu X; Liu H; Song X; Sun N; Zhong H; Qiu X; Yang X; Jiang B
Eur J Med Chem; 2021 Jun; 218():113328. PubMed ID: 33773286
[TBL] [Abstract][Full Text] [Related]
4. Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
Zhang H; Zhao HY; Xi XX; Liu YJ; Xin M; Mao S; Zhang JJ; Lu AX; Zhang SQ
Eur J Med Chem; 2020 Mar; 189():112061. PubMed ID: 31951960
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis and biological evaluation of 6-(nitroimidazole-1H-alkyloxyl)-4-anilinoquinazolines as efficient EGFR inhibitors exerting cytotoxic effects both under normoxia and hypoxia.
Cheng W; Zhu S; Ma X; Qiu N; Peng P; Sheng R; Hu Y
Eur J Med Chem; 2015 Jan; 89():826-34. PubMed ID: 25462282
[TBL] [Abstract][Full Text] [Related]
6. Discovery of potent small molecule PROTACs targeting mutant EGFR.
Zhao HY; Yang XY; Lei H; Xi XX; Lu SM; Zhang JJ; Xin M; Zhang SQ
Eur J Med Chem; 2020 Dec; 208():112781. PubMed ID: 32883633
[TBL] [Abstract][Full Text] [Related]
7. Design and synthesis of selective degraders of EGFR
Zhang X; Xu F; Tong L; Zhang T; Xie H; Lu X; Ren X; Ding K
Eur J Med Chem; 2020 Apr; 192():112199. PubMed ID: 32171162
[TBL] [Abstract][Full Text] [Related]
8. Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs.
Liang D; Wu X; Hasinoff BB; Herbert DE; Tranmer GK
Molecules; 2018 Aug; 23(8):. PubMed ID: 30111719
[TBL] [Abstract][Full Text] [Related]
9. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP.
Zheng M; Huo J; Gu X; Wang Y; Wu C; Zhang Q; Wang W; Liu Y; Liu Y; Zhou X; Chen L; Zhou Y; Li H
J Med Chem; 2021 Jun; 64(11):7839-7852. PubMed ID: 34038131
[TBL] [Abstract][Full Text] [Related]
10. Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges.
Zeng S; Huang W; Zheng X; Liyan Cheng ; Zhang Z; Wang J; Shen Z
Eur J Med Chem; 2021 Jan; 210():112981. PubMed ID: 33160761
[TBL] [Abstract][Full Text] [Related]
11. Targeting Epidermal Growth Factor Receptor in Non-Small-Cell-Lung Cancer: Current State and Future Perspective.
Bao SM; Hu QH; Yang WT; Wang Y; Tong YP; Bao WD
Anticancer Agents Med Chem; 2019; 19(8):984-991. PubMed ID: 30868964
[TBL] [Abstract][Full Text] [Related]
12. Discovery of estrogen receptor α targeting caged hypoxia-responsive PROTACs with an inherent bicyclic skeleton for breast cancer treatment.
Xie B; Xu B; Xin L; Wei Y; Guo X; Dong C
Bioorg Chem; 2023 Aug; 137():106590. PubMed ID: 37163809
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis and biological evaluation of novel 4-anilinoquinazoline derivatives as hypoxia-selective EGFR and VEGFR-2 dual inhibitors.
Wei H; Duan Y; Gou W; Cui J; Ning H; Li D; Qin Y; Liu Q; Li Y
Eur J Med Chem; 2019 Nov; 181():111552. PubMed ID: 31387063
[TBL] [Abstract][Full Text] [Related]
14. Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy.
Li X; Song Y
J Hematol Oncol; 2020 May; 13(1):50. PubMed ID: 32404196
[TBL] [Abstract][Full Text] [Related]
15. Aptamer-PROTAC Conjugates (APCs) for Tumor-Specific Targeting in Breast Cancer.
He S; Gao F; Ma J; Ma H; Dong G; Sheng C
Angew Chem Int Ed Engl; 2021 Oct; 60(43):23299-23305. PubMed ID: 34240523
[TBL] [Abstract][Full Text] [Related]
16. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders.
Yang J; Li Y; Aguilar A; Liu Z; Yang CY; Wang S
J Med Chem; 2019 Nov; 62(21):9471-9487. PubMed ID: 31560543
[TBL] [Abstract][Full Text] [Related]
17. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer.
Kozlova N; Wottawa M; Katschinski DM; Kristiansen G; Kietzmann T
Oncotarget; 2017 Feb; 8(6):9885-9898. PubMed ID: 28038470
[TBL] [Abstract][Full Text] [Related]
18. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).
Schiedel M; Herp D; Hammelmann S; Swyter S; Lehotzky A; Robaa D; Oláh J; Ovádi J; Sippl W; Jung M
J Med Chem; 2018 Jan; 61(2):482-491. PubMed ID: 28379698
[TBL] [Abstract][Full Text] [Related]
19. New strategy for renal fibrosis: Targeting Smad3 proteins for ubiquitination and degradation.
Wang X; Feng S; Fan J; Li X; Wen Q; Luo N
Biochem Pharmacol; 2016 Sep; 116():200-9. PubMed ID: 27473774
[TBL] [Abstract][Full Text] [Related]
20. The PROTAC technology in drug development.
Zou Y; Ma D; Wang Y
Cell Biochem Funct; 2019 Jan; 37(1):21-30. PubMed ID: 30604499
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]