145 related articles for article (PubMed ID: 34802838)
1. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates.
Li Y; Ouyang Y; Wu H; Wang P; Huang Y; Li X; Chen H; Sun Y; Hu X; Wang X; Li G; Lu Y; Li C; Lu X; Pang J; Nie T; Sang X; Dong L; Dong W; Jiang J; Paterson IC; Yang X; Hong W; Wang H; You X
Eur J Med Chem; 2022 Jan; 228():113979. PubMed ID: 34802838
[TBL] [Abstract][Full Text] [Related]
2. The Anti-Multidrug-Resistant
Wu H; Chen H; Zhang J; Hu X; Xie C; Cao W; Zhao Z; Xiao Z; Ren Y; Dong L; Sun P; You X; Yang X; Hong W; Wang H
Molecules; 2022 Dec; 27(23):. PubMed ID: 36500701
[TBL] [Abstract][Full Text] [Related]
3. Characterizing the Antimicrobial Activity of
Fleeman R; Van Horn KS; Barber MM; Burda WN; Flanigan DL; Manetsch R; Shaw LN
Antimicrob Agents Chemother; 2017 Jun; 61(6):. PubMed ID: 28289036
[TBL] [Abstract][Full Text] [Related]
4. Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.
Reeve SM; Scocchera E; Ferreira JJ; G-Dayanandan N; Keshipeddy S; Wright DL; Anderson AC
J Med Chem; 2016 Jul; 59(13):6493-500. PubMed ID: 27308944
[TBL] [Abstract][Full Text] [Related]
5. Exploration and Biological Evaluation of 1,3-Diamino-7
Zhu Z; Chen C; Zhang J; Lai F; Feng J; Wu G; Xia J; Zhang W; Han Z; Zhang C; Yang Q; Wang Y; Liu B; Li T; Wu S
J Med Chem; 2023 Oct; 66(20):13946-13967. PubMed ID: 37698518
[TBL] [Abstract][Full Text] [Related]
6. Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant
Reeve SM; Si D; Krucinska J; Yan Y; Viswanathan K; Wang S; Holt GT; Frenkel MS; Ojewole AA; Estrada A; Agabiti SS; Alverson JB; Gibson ND; Priestley ND; Wiemer AJ; Donald BR; Wright DL
ACS Infect Dis; 2019 Nov; 5(11):1896-1906. PubMed ID: 31565920
[TBL] [Abstract][Full Text] [Related]
7. New imidazolone derivatives comprising a benzoate or sulfonamide moiety as anti-inflammatory and antibacterial inhibitors: Design, synthesis, selective COX-2, DHFR and molecular-modeling study.
Metwally NH; Mohamed MS
Bioorg Chem; 2020 Jun; 99():103438. PubMed ID: 31796216
[TBL] [Abstract][Full Text] [Related]
8. Pharmacological validation of dihydrofolate reductase as a drug target in
Aragaw WW; Negatu DA; Bungard CJ; Dartois VA; Marrouni AE; Nickbarg EB; Olsen DB; Warrass R; Dick T
Antimicrob Agents Chemother; 2024 Jan; 68(1):e0071723. PubMed ID: 38018963
[TBL] [Abstract][Full Text] [Related]
9. Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity.
Hassan AS; Askar AA; Naglah AM; Almehizia AA; Ragab A
Molecules; 2020 Jun; 25(11):. PubMed ID: 32498469
[TBL] [Abstract][Full Text] [Related]
10. Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.
Keshipeddy S; Reeve SM; Anderson AC; Wright DL
J Am Chem Soc; 2015 Jul; 137(28):8983-90. PubMed ID: 26098608
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
Gangjee A; Lin X; Kisliuk RL; McGuire JJ
J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
[TBL] [Abstract][Full Text] [Related]
12. The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling.
Hong W; Wang Y; Chang Z; Yang Y; Pu J; Sun T; Kaur S; Sacchettini JC; Jung H; Lin Wong W; Fah Yap L; Fong Ngeow Y; Paterson IC; Wang H
Sci Rep; 2015 Oct; 5():15328. PubMed ID: 26471125
[TBL] [Abstract][Full Text] [Related]
13. Deletion of
Li K; Li T; Yang SS; Wang XD; Gao LX; Wang RQ; Gu J; Zhang XE; Deng JY
Antimicrob Agents Chemother; 2017 May; 61(5):. PubMed ID: 28223385
[TBL] [Abstract][Full Text] [Related]
14. Design, Synthesis and Biological Evaluation of 7-Substituted-1,3-diaminopyrrol[3,2-f]quinazolines as Potential Antibacterial Agents.
Yuan D; Liu S; Li S; Liu R; Zhu X
ChemMedChem; 2023 Jun; 18(12):e202300078. PubMed ID: 37017005
[TBL] [Abstract][Full Text] [Related]
15. Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance.
Frey KM; Viswanathan K; Wright DL; Anderson AC
Antimicrob Agents Chemother; 2012 Jul; 56(7):3556-62. PubMed ID: 22491688
[TBL] [Abstract][Full Text] [Related]
16. Synthesis, Antimicrobial Evaluation and Molecular Docking of Some Potential 2,6-disubstituted 1H-Benzimidazoles; Non-Classical Antifolates.
Harer S; Bhatia M; Kawade V
Med Chem; 2019; 15(7):813-832. PubMed ID: 30727904
[TBL] [Abstract][Full Text] [Related]
17. Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.
Srinivasan B; Tonddast-Navaei S; Skolnick J
Eur J Med Chem; 2015 Oct; 103():600-14. PubMed ID: 26414808
[TBL] [Abstract][Full Text] [Related]
18. Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.
Wyatt EE; Galloway WR; Thomas GL; Welch M; Loiseleur O; Plowright AT; Spring DR
Chem Commun (Camb); 2008 Oct; (40):4962-4. PubMed ID: 18931753
[TBL] [Abstract][Full Text] [Related]
19. Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.
Lam T; Hilgers MT; Cunningham ML; Kwan BP; Nelson KJ; Brown-Driver V; Ong V; Trzoss M; Hough G; Shaw KJ; Finn J
J Med Chem; 2014 Feb; 57(3):651-68. PubMed ID: 24428639
[TBL] [Abstract][Full Text] [Related]
20. Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus.
Gatadi S; Gour J; Shukla M; Kaul G; Das S; Dasgupta A; Malasala S; Borra RS; Madhavi YV; Chopra S; Nanduri S
Eur J Med Chem; 2018 Sep; 157():1056-1067. PubMed ID: 30176536
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
