149 related articles for article (PubMed ID: 3485239)
1. Contribution of N-oxygenation to the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparations.
Cashman JR; Ziegler DM
Mol Pharmacol; 1986 Feb; 29(2):163-7. PubMed ID: 3485239
[TBL] [Abstract][Full Text] [Related]
2. Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
Chiba K; Kubota E; Miyakawa T; Kato Y; Ishizaki T
J Pharmacol Exp Ther; 1988 Sep; 246(3):1108-15. PubMed ID: 3262153
[TBL] [Abstract][Full Text] [Related]
3. Quantitative analysis of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolism in isolated rat hepatocytes.
Di Monte D; Shinka T; Sandy MS; Castagnoli N; Smith MT
Drug Metab Dispos; 1988; 16(2):250-5. PubMed ID: 2898342
[TBL] [Abstract][Full Text] [Related]
4. Cytochrome P4502D and -2C enzymes catalyze the oxidative N-demethylation of the parkinsonism-inducing substance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in rat liver microsomes.
Narimatsu S; Tachibana M; Masubuchi Y; Suzuki T
Chem Res Toxicol; 1996; 9(1):93-8. PubMed ID: 8924622
[TBL] [Abstract][Full Text] [Related]
5. Biotransformation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes.
Di Monte DA; Wu EY; Irwin I; Delanney LE; Langston JW
J Pharmacol Exp Ther; 1991 Aug; 258(2):594-600. PubMed ID: 1907660
[TBL] [Abstract][Full Text] [Related]
6. Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).
Uehara S; Uno Y; Inoue T; Murayama N; Shimizu M; Sasaki E; Yamazaki H
Drug Metab Dispos; 2015 May; 43(5):735-42. PubMed ID: 25735838
[TBL] [Abstract][Full Text] [Related]
7. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
Coleman T; Ellis SW; Martin IJ; Lennard MS; Tucker GT
J Pharmacol Exp Ther; 1996 May; 277(2):685-90. PubMed ID: 8627546
[TBL] [Abstract][Full Text] [Related]
8. On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. II. Susceptibility among mammalian species correlates with the toxin's metabolic patterns in brain microvessels and liver.
Riachi NJ; Harik SI; Kalaria RN; Sayre LM
J Pharmacol Exp Ther; 1988 Feb; 244(2):443-8. PubMed ID: 3258032
[TBL] [Abstract][Full Text] [Related]
9. Involvement of hepatic aldehyde oxidase in conversion of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+) to 1-methyl-4-phenyl-5,6-dihydro-2-pyridone.
Yoshihara S; Ohta S
Arch Biochem Biophys; 1998 Dec; 360(1):93-8. PubMed ID: 9826433
[TBL] [Abstract][Full Text] [Related]
10. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
Herraiz T; Guillén H; Arán VJ; Idle JR; Gonzalez FJ
Toxicol Appl Pharmacol; 2006 Nov; 216(3):387-98. PubMed ID: 16870220
[TBL] [Abstract][Full Text] [Related]
11. Facile N-oxygenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by the flavin-containing monooxygenase. A convenient synthesis of tritiated [methyl-3H]-4-phenyl-2,3-dihydropyridinium species.
Cashman JR
J Med Chem; 1988 Jun; 31(6):1258-61. PubMed ID: 3259630
[TBL] [Abstract][Full Text] [Related]
12. Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Chiba K; Peterson LA; Castagnoli KP; Trevor AJ; Castagnoli N
Drug Metab Dispos; 1985; 13(3):342-7. PubMed ID: 2861994
[TBL] [Abstract][Full Text] [Related]
13. Enantioselective N-oxygenation of verapamil by the hepatic flavin-containing monooxygenase.
Cashman JR
Mol Pharmacol; 1989 Sep; 36(3):497-503. PubMed ID: 2779529
[TBL] [Abstract][Full Text] [Related]
14. Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrroline.
Ogunrombi MO; Malan SF; Terre'Blanche G; Castagnoli K; Castagnoli N; Bergh JJ; Petzer JP
Life Sci; 2007 Jul; 81(6):458-67. PubMed ID: 17655878
[TBL] [Abstract][Full Text] [Related]
15. Stereoselective S-oxygenation of 2-aryl-1,3-dithiolanes by the flavin-containing and cytochrome P-450 monooxygenases.
Cashman JR; Olsen LD
Mol Pharmacol; 1990 Oct; 38(4):573-85. PubMed ID: 2233694
[TBL] [Abstract][Full Text] [Related]
16. Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractions.
Weissman J; Trevor A; Chiba K; Peterson LA; Caldera P; Castagnoli N; Baillie T
J Med Chem; 1985 Aug; 28(8):997-1001. PubMed ID: 3874963
[TBL] [Abstract][Full Text] [Related]
17. A reactive metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is formed in rat brain in vitro by type B monoamine oxidase.
Corsini GU; Pintus S; Bocchetta A; Piccardi MP; Del Zompo M
J Pharmacol Exp Ther; 1986 Aug; 238(2):648-52. PubMed ID: 3488394
[TBL] [Abstract][Full Text] [Related]
18. The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine.
Williams DE; Reed RL; Kedzierski B; Ziegler DM; Buhler DR
Drug Metab Dispos; 1989; 17(4):380-6. PubMed ID: 2571476
[TBL] [Abstract][Full Text] [Related]
19. Metabolic studies on the nigrostriatal toxin MPTP and its MAO B generated dihydropyridinium metabolite MPDP+.
Wu E; Shinka T; Caldera-Munoz P; Yoshizumi H; Trevor A; Castagnoli N
Chem Res Toxicol; 1988; 1(3):186-94. PubMed ID: 2979730
[TBL] [Abstract][Full Text] [Related]
20. Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.
Inoue H; Castagnoli K; Van Der Schyf C; Mabic S; Igarashi K; Castagnoli N
J Pharmacol Exp Ther; 1999 Nov; 291(2):856-64. PubMed ID: 10525109
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
