These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

248 related articles for article (PubMed ID: 34895657)

  • 1. Structure driven compound optimization in targeted protein degradation.
    Leissing TM; Luh LM; Cromm PM
    Drug Discov Today Technol; 2020 Dec; 37():73-82. PubMed ID: 34895657
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeted protein degradation and the enzymology of degraders.
    Fisher SL; Phillips AJ
    Curr Opin Chem Biol; 2018 Jun; 44():47-55. PubMed ID: 29885948
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.
    Rothweiler EM; Brennan PE; Huber KVM
    Biol Chem; 2022 Mar; 403(4):391-402. PubMed ID: 35191283
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeted protein degradation via intramolecular bivalent glues.
    Hsia O; Hinterndorfer M; Cowan AD; Iso K; Ishida T; Sundaramoorthy R; Nakasone MA; Imrichova H; Schätz C; Rukavina A; Husnjak K; Wegner M; Correa-Sáez A; Craigon C; Casement R; Maniaci C; Testa A; Kaulich M; Dikic I; Winter GE; Ciulli A
    Nature; 2024 Mar; 627(8002):204-211. PubMed ID: 38383787
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Perspectives on the development of first-in-class protein degraders.
    Rambacher KM; Calabrese MF; Yamaguchi M
    Future Med Chem; 2021 Jul; 13(14):1203-1226. PubMed ID: 34015962
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The rise of covalent proteolysis targeting chimeras.
    Gabizon R; London N
    Curr Opin Chem Biol; 2021 Jun; 62():24-33. PubMed ID: 33549806
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs.
    Winter GE
    ACS Chem Biol; 2024 Oct; 19(10):2089-2102. PubMed ID: 39264973
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ligandability of E3 Ligases for Targeted Protein Degradation Applications.
    Belcher BP; Ward CC; Nomura DK
    Biochemistry; 2023 Feb; 62(3):588-600. PubMed ID: 34473924
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications.
    Ward CC; Kleinman JI; Brittain SM; Lee PS; Chung CYS; Kim K; Petri Y; Thomas JR; Tallarico JA; McKenna JM; Schirle M; Nomura DK
    ACS Chem Biol; 2019 Nov; 14(11):2430-2440. PubMed ID: 31059647
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Current Challenges in Small Molecule Proximity-Inducing Compound Development for Targeted Protein Degradation Using the Ubiquitin Proteasomal System.
    Radhakrishnan S; Hoff O; Muellner MK
    Molecules; 2022 Nov; 27(23):. PubMed ID: 36500212
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The importance of cellular degradation kinetics for understanding mechanisms in targeted protein degradation.
    Riching KM; Caine EA; Urh M; Daniels DL
    Chem Soc Rev; 2022 Jul; 51(14):6210-6221. PubMed ID: 35792307
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic.
    Sasso JM; Tenchov R; Wang D; Johnson LS; Wang X; Zhou QA
    Biochemistry; 2023 Feb; 62(3):601-623. PubMed ID: 35856839
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues.
    Ramachandran S; Ciulli A
    Curr Opin Struct Biol; 2021 Apr; 67():110-119. PubMed ID: 33271439
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mathematical Model for Covalent Proteolysis Targeting Chimeras: Thermodynamics and Kinetics Underlying Catalytic Efficiency.
    Chaudhry C
    J Med Chem; 2023 May; 66(9):6239-6250. PubMed ID: 37102218
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.
    Kagiou C; Cisneros JA; Farnung J; Liwocha J; Offensperger F; Dong K; Yang K; Tin G; Horstmann CS; Hinterndorfer M; Paulo JA; Scholes NS; Sanchez Avila J; Fellner M; Andersch F; Hannich JT; Zuber J; Kubicek S; Gygi SP; Schulman BA; Winter GE
    Nat Commun; 2024 Jun; 15(1):5409. PubMed ID: 38926334
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts.
    Chernobrovkin AL; Cázares-Körner C; Friman T; Caballero IM; Amadio D; Martinez Molina D
    SLAS Discov; 2021 Apr; 26(4):534-546. PubMed ID: 33445986
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Quantitative Measurement of Rate of Targeted Protein Degradation.
    Lynch TL; Marin VL; McClure RA; Phipps C; Ronau JA; Rouhimoghadam M; Adams AM; Kandi S; Wolke ML; Shergalis AG; Potts GK; Nacham O; Richardson P; Kakavas SJ; Chhor G; Jenkins GJ; Woller KR; Warder SE; Vasudevan A; Reitsma JM
    ACS Chem Biol; 2024 Jul; 19(7):1604-1615. PubMed ID: 38980123
    [TBL] [Abstract][Full Text] [Related]  

  • 18. cIAP1-based degraders induce degradation via branched ubiquitin architectures.
    Akizuki Y; Morita M; Mori Y; Kaiho-Soma A; Dixit S; Endo A; Shimogawa M; Hayashi G; Naito M; Okamoto A; Tanaka K; Saeki Y; Ohtake F
    Nat Chem Biol; 2023 Mar; 19(3):311-322. PubMed ID: 36316570
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Chemically Induced Cellular Proteolysis: An Emerging Therapeutic Strategy for Undruggable Targets.
    Moon S; Lee BH
    Mol Cells; 2018 Nov; 41(11):933-942. PubMed ID: 30486612
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
    Bondeson DP; Smith BE; Burslem GM; Buhimschi AD; Hines J; Jaime-Figueroa S; Wang J; Hamman BD; Ishchenko A; Crews CM
    Cell Chem Biol; 2018 Jan; 25(1):78-87.e5. PubMed ID: 29129718
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.