BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

225 related articles for article (PubMed ID: 34935961)

  • 1. Disrupting the Cdk9/Cyclin T1 heterodimer of 7SK snRNP for the Brd4 and AFF1/4 guided reconstitution of active P-TEFb.
    Zhou K; Zhuang S; Liu F; Chen Y; Li Y; Wang S; Li Y; Wen H; Lin X; Wang J; Huang Y; He C; Xu N; Li Z; Xu L; Zhang Z; Chen LF; Chen R; Liu M
    Nucleic Acids Res; 2022 Jan; 50(2):750-762. PubMed ID: 34935961
    [TBL] [Abstract][Full Text] [Related]  

  • 2. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.
    Lu H; Li Z; Xue Y; Schulze-Gahmen U; Johnson JR; Krogan NJ; Alber T; Zhou Q
    Proc Natl Acad Sci U S A; 2014 Jan; 111(1):E15-24. PubMed ID: 24367103
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.
    Chen R; Liu M; Li H; Xue Y; Ramey WN; He N; Ai N; Luo H; Zhu Y; Zhou N; Zhou Q
    Genes Dev; 2008 May; 22(10):1356-68. PubMed ID: 18483222
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.
    Liu P; Xiang Y; Fujinaga K; Bartholomeeusen K; Nilson KA; Price DH; Peterlin BM
    J Biol Chem; 2014 Apr; 289(14):9918-25. PubMed ID: 24515107
    [TBL] [Abstract][Full Text] [Related]  

  • 5. T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
    Dow EC; Liu H; Rice AP
    J Cell Physiol; 2010 Jul; 224(1):84-93. PubMed ID: 20201073
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.
    Mbonye UR; Gokulrangan G; Datt M; Dobrowolski C; Cooper M; Chance MR; Karn J
    PLoS Pathog; 2013; 9(5):e1003338. PubMed ID: 23658523
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.
    Mbonye U; Wang B; Gokulrangan G; Shi W; Yang S; Karn J
    J Biol Chem; 2018 Jun; 293(26):10009-10025. PubMed ID: 29743242
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.
    Bartholomeeusen K; Xiang Y; Fujinaga K; Peterlin BM
    J Biol Chem; 2012 Oct; 287(43):36609-16. PubMed ID: 22952229
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding.
    Cho WK; Jang MK; Huang K; Pise-Masison CA; Brady JN
    J Virol; 2010 Dec; 84(24):12801-9. PubMed ID: 20926576
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.
    Schröder S; Cho S; Zeng L; Zhang Q; Kaehlcke K; Mak L; Lau J; Bisgrove D; Schnölzer M; Verdin E; Zhou MM; Ott M
    J Biol Chem; 2012 Jan; 287(2):1090-9. PubMed ID: 22084242
    [TBL] [Abstract][Full Text] [Related]  

  • 11. HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.
    Sobhian B; Laguette N; Yatim A; Nakamura M; Levy Y; Kiernan R; Benkirane M
    Mol Cell; 2010 May; 38(3):439-51. PubMed ID: 20471949
    [TBL] [Abstract][Full Text] [Related]  

  • 12. AFF4 globally affects the release of paused RNA polymerase II in HEL cells.
    Yang ZM; Zhang G; Wei G; Jing LL; Yu M
    Yi Chuan; 2023 Aug; 45(8):658-668. PubMed ID: 37609817
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.
    Chen R; Yang Z; Zhou Q
    J Biol Chem; 2004 Feb; 279(6):4153-60. PubMed ID: 14627702
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK.
    Krueger BJ; Varzavand K; Cooper JJ; Price DH
    PLoS One; 2010 Aug; 5(8):e12335. PubMed ID: 20808803
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells.
    Fujinaga K; Luo Z; Peterlin BM
    J Biol Chem; 2014 Jul; 289(30):21181-90. PubMed ID: 24917669
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.
    Zhou M; Huang K; Jung KJ; Cho WK; Klase Z; Kashanchi F; Pise-Masison CA; Brady JN
    J Virol; 2009 Jan; 83(2):1036-44. PubMed ID: 18971272
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.
    Yang Z; Yik JH; Chen R; He N; Jang MK; Ozato K; Zhou Q
    Mol Cell; 2005 Aug; 19(4):535-45. PubMed ID: 16109377
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.
    Michels AA; Fraldi A; Li Q; Adamson TE; Bonnet F; Nguyen VT; Sedore SC; Price JP; Price DH; Lania L; Bensaude O
    EMBO J; 2004 Jul; 23(13):2608-19. PubMed ID: 15201869
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription.
    Kuzmina A; Verstraete N; Galker S; Maatook M; Bensaude O; Taube R
    Retrovirology; 2014 Jul; 11():51. PubMed ID: 24985467
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.
    Li Q; Price JP; Byers SA; Cheng D; Peng J; Price DH
    J Biol Chem; 2005 Aug; 280(31):28819-26. PubMed ID: 15965233
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.