BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

227 related articles for article (PubMed ID: 34942146)

  • 1. Activation of the SARS-CoV-2 NSP14 3'-5' exoribonuclease by NSP10 and response to antiviral inhibitors.
    Riccio AA; Sullivan ED; Copeland WC
    J Biol Chem; 2022 Jan; 298(1):101518. PubMed ID: 34942146
    [TBL] [Abstract][Full Text] [Related]  

  • 2. New targets for drug design: importance of nsp14/nsp10 complex formation for the 3'-5' exoribonucleolytic activity on SARS-CoV-2.
    Saramago M; Bárria C; Costa VG; Souza CS; Viegas SC; Domingues S; Lousa D; Soares CM; Arraiano CM; Matos RG
    FEBS J; 2021 Sep; 288(17):5130-5147. PubMed ID: 33705595
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification.
    Baddock HT; Brolih S; Yosaatmadja Y; Ratnaweera M; Bielinski M; Swift LP; Cruz-Migoni A; Fan H; Keown JR; Walker AP; Morris GM; Grimes JM; Fodor E; Schofield CJ; Gileadi O; McHugh PJ
    Nucleic Acids Res; 2022 Feb; 50(3):1484-1500. PubMed ID: 35037045
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target.
    Rona G; Zeke A; Miwatani-Minter B; de Vries M; Kaur R; Schinlever A; Garcia SF; Goldberg HV; Wang H; Hinds TR; Bailly F; Zheng N; Cotelle P; Desmaële D; Landau NR; Dittmann M; Pagano M
    Cell Death Differ; 2022 Feb; 29(2):285-292. PubMed ID: 34862481
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity.
    Lin S; Chen H; Chen Z; Yang F; Ye F; Zheng Y; Yang J; Lin X; Sun H; Wang L; Wen A; Dong H; Xiao Q; Deng D; Cao Y; Lu G
    Nucleic Acids Res; 2021 May; 49(9):5382-5392. PubMed ID: 33956156
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Reconstitution and functional characterization of SARS-CoV-2 proofreading complex.
    Ma Z; Pourfarjam Y; Kim IK
    Protein Expr Purif; 2021 Sep; 185():105894. PubMed ID: 33933612
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.
    Ogando NS; Zevenhoven-Dobbe JC; van der Meer Y; Bredenbeek PJ; Posthuma CC; Snijder EJ
    J Virol; 2020 Nov; 94(23):. PubMed ID: 32938769
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease.
    Canal B; McClure AW; Curran JF; Wu M; Ulferts R; Weissmann F; Zeng J; Bertolin AP; Milligan JC; Basu S; Drury LS; Deegan TD; Fujisawa R; Roberts EL; Basier C; Labib K; Beale R; Howell M; Diffley JFX
    Biochem J; 2021 Jul; 478(13):2445-2464. PubMed ID: 34198326
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.
    Imprachim N; Yosaatmadja Y; Newman JA
    Nucleic Acids Res; 2023 Jan; 51(1):475-487. PubMed ID: 36546776
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry.
    Scholle MD; Liu C; Deval J; Gurard-Levin ZA
    SLAS Discov; 2021 Jul; 26(6):766-774. PubMed ID: 33870746
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.
    Bouvet M; Lugari A; Posthuma CC; Zevenhoven JC; Bernard S; Betzi S; Imbert I; Canard B; Guillemot JC; Lécine P; Pfefferle S; Drosten C; Snijder EJ; Decroly E; Morelli X
    J Biol Chem; 2014 Sep; 289(37):25783-96. PubMed ID: 25074927
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex.
    Ma Y; Wu L; Shaw N; Gao Y; Wang J; Sun Y; Lou Z; Yan L; Zhang R; Rao Z
    Proc Natl Acad Sci U S A; 2015 Jul; 112(30):9436-41. PubMed ID: 26159422
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.
    Czarna A; Plewka J; Kresik L; Matsuda A; Karim A; Robinson C; O'Byrne S; Cunningham F; Georgiou I; Wilk P; Pachota M; Popowicz G; Wyatt PG; Dubin G; Pyrć K
    Structure; 2022 Aug; 30(8):1050-1054.e2. PubMed ID: 35609600
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and potentiate the activity of chain terminating drugs.
    Narayanan N; Nair DT
    Int J Biol Macromol; 2021 Jan; 168():272-278. PubMed ID: 33309661
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity.
    Smith EC; Case JB; Blanc H; Isakov O; Shomron N; Vignuzzi M; Denison MR
    J Virol; 2015 Jun; 89(12):6418-26. PubMed ID: 25855750
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry.
    Pearson LA; Green CJ; Lin D; Petit AP; Gray DW; Cowling VH; Fordyce EAF
    SLAS Discov; 2021 Jul; 26(6):749-756. PubMed ID: 33724070
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN.
    Moeller NH; Shi K; Demir Ö; Belica C; Banerjee S; Yin L; Durfee C; Amaro RE; Aihara H
    Proc Natl Acad Sci U S A; 2022 Mar; 119(9):. PubMed ID: 35165203
    [TBL] [Abstract][Full Text] [Related]  

  • 18. RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex.
    Bouvet M; Imbert I; Subissi L; Gluais L; Canard B; Decroly E
    Proc Natl Acad Sci U S A; 2012 Jun; 109(24):9372-7. PubMed ID: 22635272
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase.
    Basu S; Mak T; Ulferts R; Wu M; Deegan T; Fujisawa R; Tan KW; Lim CT; Basier C; Canal B; Curran JF; Drury LS; McClure AW; Roberts EL; Weissmann F; Zeisner TU; Beale R; Cowling VH; Howell M; Labib K; Diffley JFX
    Biochem J; 2021 Jul; 478(13):2481-2497. PubMed ID: 34198328
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target.
    Tahir M
    J Med Virol; 2021 Jul; 93(7):4258-4264. PubMed ID: 33837972
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.