These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
182 related articles for article (PubMed ID: 34959646)
1. Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases. Santucci M; Luciani R; Gianquinto E; Pozzi C; Pisa FD; Dello Iacono L; Landi G; Tagliazucchi L; Mangani S; Spyrakis F; Costi MP Pharmaceuticals (Basel); 2021 Nov; 14(12):. PubMed ID: 34959646 [TBL] [Abstract][Full Text] [Related]
2. Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways. Hardy LW; Matthews W; Nare B; Beverley SM Exp Parasitol; 1997 Nov; 87(3):157-69. PubMed ID: 9371081 [TBL] [Abstract][Full Text] [Related]
3. Biochemical and Genetic Tests for Inhibitors of Leishmania Pteridine Pathways. Hardy LW; Matthews W; Nare B; Beverley SM Exp Parasitol; 1997 Nov; 87(3):158-70. PubMed ID: 9398595 [TBL] [Abstract][Full Text] [Related]
4. Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. Tulloch LB; Martini VP; Iulek J; Huggan JK; Lee JH; Gibson CL; Smith TK; Suckling CJ; Hunter WN J Med Chem; 2010 Jan; 53(1):221-9. PubMed ID: 19916554 [TBL] [Abstract][Full Text] [Related]
5. In Silico and In Vitro Search for Dual Inhibitors of the Possart K; Herrmann FC; Jose J; Schmidt TJ Molecules; 2023 Nov; 28(22):. PubMed ID: 38005256 [TBL] [Abstract][Full Text] [Related]
6. The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major. Nare B; Hardy LW; Beverley SM J Biol Chem; 1997 May; 272(21):13883-91. PubMed ID: 9153248 [TBL] [Abstract][Full Text] [Related]
8. New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity. Nare B; Luba J; Hardy LW; Beverley S Parasitology; 1997; 114 Suppl():S101-10. PubMed ID: 9309772 [TBL] [Abstract][Full Text] [Related]
9. Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. Pöhner I; Quotadamo A; Panecka-Hofman J; Luciani R; Santucci M; Linciano P; Landi G; Di Pisa F; Dello Iacono L; Pozzi C; Mangani S; Gul S; Witt G; Ellinger B; Kuzikov M; Santarem N; Cordeiro-da-Silva A; Costi MP; Venturelli A; Wade RC J Med Chem; 2022 Jul; 65(13):9011-9033. PubMed ID: 35675511 [TBL] [Abstract][Full Text] [Related]
10. Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum. Bhattacharya A; Leprohon P; Ouellette M PLoS Negl Trop Dis; 2021 Apr; 15(4):e0009377. PubMed ID: 33905412 [TBL] [Abstract][Full Text] [Related]
11. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Cavazzuti A; Paglietti G; Hunter WN; Gamarro F; Piras S; Loriga M; Allecca S; Corona P; McLuskey K; Tulloch L; Gibellini F; Ferrari S; Costi MP Proc Natl Acad Sci U S A; 2008 Feb; 105(5):1448-53. PubMed ID: 18245389 [TBL] [Abstract][Full Text] [Related]
12. High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor. Landi G; Linciano P; Tassone G; Costi MP; Mangani S; Pozzi C Acta Crystallogr D Struct Biol; 2020 Jun; 76(Pt 6):558-564. PubMed ID: 32496217 [TBL] [Abstract][Full Text] [Related]
13. Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Herrera-Acevedo C; de Menezes RPB; de Sousa NF; Scotti L; Scotti MT; Coy-Barrera E Antibiotics (Basel); 2023 Mar; 12(4):. PubMed ID: 37107025 [TBL] [Abstract][Full Text] [Related]
14. Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Tassone G; Landi G; Linciano P; Francesconi V; Tonelli M; Tagliazucchi L; Costi MP; Mangani S; Pozzi C Pharmaceuticals (Basel); 2021 Jun; 14(7):. PubMed ID: 34209148 [No Abstract] [Full Text] [Related]
15. Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors. Panecka-Hofman J; Pöhner I; Spyrakis F; Zeppelin T; Di Pisa F; Dello Iacono L; Bonucci A; Quotadamo A; Venturelli A; Mangani S; Costi MP; Wade RC Biochim Biophys Acta Gen Subj; 2017 Dec; 1861(12):3215-3230. PubMed ID: 28939533 [TBL] [Abstract][Full Text] [Related]
16. Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy. Cunningham ML; Beverley SM Mol Biochem Parasitol; 2001 Apr; 113(2):199-213. PubMed ID: 11295174 [TBL] [Abstract][Full Text] [Related]
17. Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity. Di Pisa F; Landi G; Dello Iacono L; Pozzi C; Borsari C; Ferrari S; Santucci M; Santarem N; Cordeiro-da-Silva A; Moraes CB; Alcantara LM; Fontana V; Freitas-Junior LH; Gul S; Kuzikov M; Behrens B; Pöhner I; Wade RC; Costi MP; Mangani S Molecules; 2017 Mar; 22(3):. PubMed ID: 28282886 [TBL] [Abstract][Full Text] [Related]
18. Structural Insights into the Development of Cycloguanil Derivatives as Landi G; Linciano P; Borsari C; Bertolacini CP; Moraes CB; Cordeiro-da-Silva A; Gul S; Witt G; Kuzikov M; Costi MP; Pozzi C; Mangani S ACS Infect Dis; 2019 Jul; 5(7):1105-1114. PubMed ID: 31012301 [TBL] [Abstract][Full Text] [Related]
19. An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. Leite FHA; Froes TQ; da Silva SG; de Souza EIM; Vital-Fujii DG; Trossini GHG; Pita SSDR; Castilho MS Eur J Med Chem; 2017 May; 132():322-332. PubMed ID: 28407565 [TBL] [Abstract][Full Text] [Related]
20. Pharmacophore Mapping, In Silico Screening and Molecular Docking to Identify Selective Trypanosoma brucei Pteridine Reductase Inhibitors. Dube D; Sharma S; Singh TP; Kaur P Mol Inform; 2014 Feb; 33(2):124-34. PubMed ID: 27485569 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]