BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

370 related articles for article (PubMed ID: 34976713)

  • 1. One oncogene, several vulnerabilities: EWS/FLI targeted therapies for Ewing sarcoma.
    Flores G; Grohar PJ
    J Bone Oncol; 2021 Dec; 31():100404. PubMed ID: 34976713
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.
    Stegmaier K; Wong JS; Ross KN; Chow KT; Peck D; Wright RD; Lessnick SL; Kung AL; Golub TR
    PLoS Med; 2007 Apr; 4(4):e122. PubMed ID: 17425403
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.
    Sankar S; Bell R; Stephens B; Zhuo R; Sharma S; Bearss DJ; Lessnick SL
    Oncogene; 2013 Oct; 32(42):5089-100. PubMed ID: 23178492
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors.
    Castillero-Trejo Y; Eliazer S; Xiang L; Richardson JA; Ilaria RL
    Cancer Res; 2005 Oct; 65(19):8698-705. PubMed ID: 16204038
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting.
    Theisen ER; Pishas KI; Saund RS; Lessnick SL
    Oncotarget; 2016 Apr; 7(14):17616-30. PubMed ID: 26848860
    [TBL] [Abstract][Full Text] [Related]  

  • 6. BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma.
    Wiles ET; Lui-Sargent B; Bell R; Lessnick SL
    PLoS One; 2013; 8(3):e59369. PubMed ID: 23527175
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma.
    Elzi DJ; Song M; Houghton PJ; Chen Y; Shiio Y
    Genes Cancer; 2015 Nov; 6(11-12):452-61. PubMed ID: 26807198
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.
    Sankar S; Theisen ER; Bearss J; Mulvihill T; Hoffman LM; Sorna V; Beckerle MC; Sharma S; Lessnick SL
    Clin Cancer Res; 2014 Sep; 20(17):4584-97. PubMed ID: 24963049
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma.
    Chaturvedi A; Hoffman LM; Welm AL; Lessnick SL; Beckerle MC
    Genes Cancer; 2012 Feb; 3(2):102-16. PubMed ID: 23050043
    [TBL] [Abstract][Full Text] [Related]  

  • 10. EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma.
    Kinsey M; Smith R; Iyer AK; McCabe ER; Lessnick SL
    Cancer Res; 2009 Dec; 69(23):9047-55. PubMed ID: 19920188
    [TBL] [Abstract][Full Text] [Related]  

  • 11. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.
    Prieur A; Tirode F; Cohen P; Delattre O
    Mol Cell Biol; 2004 Aug; 24(16):7275-83. PubMed ID: 15282325
    [TBL] [Abstract][Full Text] [Related]  

  • 12. EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma.
    Owen LA; Kowalewski AA; Lessnick SL
    PLoS One; 2008 Apr; 3(4):e1965. PubMed ID: 18414662
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model.
    Takigami I; Ohno T; Kitade Y; Hara A; Nagano A; Kawai G; Saitou M; Matsuhashi A; Yamada K; Shimizu K
    Int J Cancer; 2011 Jan; 128(1):216-26. PubMed ID: 20648560
    [TBL] [Abstract][Full Text] [Related]  

  • 14. EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma.
    Fadul J; Bell R; Hoffman LM; Beckerle MC; Engel ME; Lessnick SL
    Genes Cancer; 2015 Mar; 6(3-4):129-43. PubMed ID: 26000096
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Anti-Epileptic Drug Targets Ewing Sarcoma.
    Kayarthodi S; Fujimura Y; Fang J; Morsalin S; Rao VN; Reddy ES
    J Pharm Sci Pharmacol; 2014 Jun; 1(2):87-100. PubMed ID: 25664332
    [TBL] [Abstract][Full Text] [Related]  

  • 16. NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma.
    Kinsey M; Smith R; Lessnick SL
    Mol Cancer Res; 2006 Nov; 4(11):851-9. PubMed ID: 17114343
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth.
    Johnson KM; Mahler NR; Saund RS; Theisen ER; Taslim C; Callender NW; Crow JC; Miller KR; Lessnick SL
    Proc Natl Acad Sci U S A; 2017 Sep; 114(37):9870-9875. PubMed ID: 28847958
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma.
    Johnson KM; Taslim C; Saund RS; Lessnick SL
    PLoS One; 2017; 12(11):e0186275. PubMed ID: 29091716
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma.
    Boone MA; Taslim C; Crow JC; Selich-Anderson J; Byrum AK; Showpnil IA; Sunkel BD; Wang M; Stanton BZ; Theisen ER; Lessnick SL
    Oncogene; 2021 Jul; 40(29):4759-4769. PubMed ID: 34145397
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.
    Kovar H
    Expert Opin Ther Targets; 2014 Nov; 18(11):1315-28. PubMed ID: 25162919
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.