140 related articles for article (PubMed ID: 34985886)
1. Discovery of 3,4-Dihydrobenzo[
Li Y; Zhang L; Yang R; Qiao Z; Wu M; Huang C; Tian C; Luo X; Yang W; Zhang Y; Li L; Yang S
J Med Chem; 2022 Feb; 65(3):1786-1807. PubMed ID: 34985886
[TBL] [Abstract][Full Text] [Related]
2. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer.
Luo X; Yang R; Li Y; Zhang L; Yang S; Li L
Bioorg Med Chem Lett; 2022 Jul; 67():128745. PubMed ID: 35447345
[TBL] [Abstract][Full Text] [Related]
3. TNIK inhibition abrogates colorectal cancer stemness.
Masuda M; Uno Y; Ohbayashi N; Ohata H; Mimata A; Kukimoto-Niino M; Moriyama H; Kashimoto S; Inoue T; Goto N; Okamoto K; Shirouzu M; Sawa M; Yamada T
Nat Commun; 2016 Aug; 7():12586. PubMed ID: 27562646
[TBL] [Abstract][Full Text] [Related]
4. Fragment growth-based discovery of novel TNIK inhibitors for the treatment of colorectal cancer.
Teng Y; Wu R; Bo W; Tang M; Wang T; Cui X; Li Y; Zhang C; Ma Z; Fu Z; Xu Q; Liu J; Chen L
Eur J Med Chem; 2024 Mar; 268():116240. PubMed ID: 38422698
[TBL] [Abstract][Full Text] [Related]
5. Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.
Ho KK; Parnell KM; Yuan Y; Xu Y; Kultgen SG; Hamblin S; Hendrickson TF; Luo B; Foulks JM; McCullar MV; Kanner SB
Bioorg Med Chem Lett; 2013 Jan; 23(2):569-73. PubMed ID: 23232060
[TBL] [Abstract][Full Text] [Related]
6. Direct conversion of osteosarcoma to adipocytes by targeting TNIK.
Hirozane T; Masuda M; Sugano T; Sekita T; Goto N; Aoyama T; Sakagami T; Uno Y; Moriyama H; Sawa M; Asano N; Nakamura M; Matsumoto M; Nakayama R; Kondo T; Kawai A; Kobayashi E; Yamada T
JCI Insight; 2021 Feb; 6(3):. PubMed ID: 33400690
[TBL] [Abstract][Full Text] [Related]
7. A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells.
Kim J; Moon SH; Kim BT; Chae CH; Lee JY; Kim SH
PLoS One; 2014; 9(10):e110180. PubMed ID: 25337707
[TBL] [Abstract][Full Text] [Related]
8. Jatrorrhizine inhibits mammary carcinoma cells by targeting TNIK mediated Wnt/β-catenin signalling and epithelial-mesenchymal transition (EMT).
Sun Y; Gao X; Wu P; Wink M; Li J; Dian L; Liang Z
Phytomedicine; 2019 Oct; 63():153015. PubMed ID: 31302315
[TBL] [Abstract][Full Text] [Related]
9. Discovery of 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one derivatives as a new class of ROCK inhibitors for the treatment of glaucoma.
Sun Y; Li Y; Miao Z; Yang R; Zhang Y; Wu M; Lin G; Li L
Bioorg Med Chem Lett; 2021 Aug; 45():128138. PubMed ID: 34044123
[TBL] [Abstract][Full Text] [Related]
10.
Yang T; Hu M; Chen Y; Xiang M; Tang M; Qi W; Shi M; He J; Yuan X; Zhang C; Liu K; Li J; Yang Z; Chen L
J Med Chem; 2020 Dec; 63(23):14921-14936. PubMed ID: 33256400
[TBL] [Abstract][Full Text] [Related]
11. Emergence of TNIK inhibitors in cancer therapeutics.
Yamada T; Masuda M
Cancer Sci; 2017 May; 108(5):818-823. PubMed ID: 28208209
[TBL] [Abstract][Full Text] [Related]
12. Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth.
Shitashige M; Satow R; Jigami T; Aoki K; Honda K; Shibata T; Ono M; Hirohashi S; Yamada T
Cancer Res; 2010 Jun; 70(12):5024-33. PubMed ID: 20530691
[TBL] [Abstract][Full Text] [Related]
13. Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-
Kurasawa O; Miyazaki T; Homma M; Oguro Y; Imada T; Uchiyama N; Iwai K; Yamamoto Y; Ohori M; Hara H; Sugimoto H; Iwata K; Skene R; Hoffman I; Ohashi A; Nomura T; Cho N
J Med Chem; 2020 Feb; 63(3):1084-1104. PubMed ID: 31895562
[TBL] [Abstract][Full Text] [Related]
14. Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors.
Zhang H; Jing L; Liu M; Goto M; Lai F; Liu X; Sheng L; Yang Y; Yang Y; Li Y; Chen X; Lee KH; Xiao Z
Eur J Med Chem; 2021 Nov; 223():113634. PubMed ID: 34147745
[TBL] [Abstract][Full Text] [Related]
15. Structural Insight into TNIK Inhibition.
Kukimoto-Niino M; Shirouzu M; Yamada T
Int J Mol Sci; 2022 Oct; 23(21):. PubMed ID: 36361804
[TBL] [Abstract][Full Text] [Related]
16. TRAF2 and NCK-Interacting Kinase Inhibitors for Colorectal Cancer: In Vitro and Theoretical Validations.
Arokiaraj SR; Tajuddin NB; Muthusamy K; Jayaraj JM; Alagumuthu M
ACS Comb Sci; 2020 Nov; 22(11):608-616. PubMed ID: 32960032
[TBL] [Abstract][Full Text] [Related]
17. The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
Heffron TP; Heald RA; Ndubaku C; Wei B; Augistin M; Do S; Edgar K; Eigenbrot C; Friedman L; Gancia E; Jackson PS; Jones G; Kolesnikov A; Lee LB; Lesnick JD; Lewis C; McLean N; Mörtl M; Nonomiya J; Pang J; Price S; Prior WW; Salphati L; Sideris S; Staben ST; Steinbacher S; Tsui V; Wallin J; Sampath D; Olivero AG
J Med Chem; 2016 Feb; 59(3):985-1002. PubMed ID: 26741947
[TBL] [Abstract][Full Text] [Related]
18. Computational study on new natural compound inhibitors of Traf2 and Nck-interacting kinase (TNIK).
Ma L; Li R; Yao Z; Wang B; Liu Y; Liu C; Wang H; Chen S; Sun D
Aging (Albany NY); 2022 Oct; 14(20):8394-8410. PubMed ID: 36287174
[TBL] [Abstract][Full Text] [Related]
19. Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity.
Abdelaziz AM; Diab S; Islam S; Basnet SKC; Noll B; Li P; Mekonnen LB; Lu J; Albrecht H; Milne RW; Gerber C; Yu M; Wang S
Med Chem; 2019; 15(6):602-623. PubMed ID: 30569866
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors.
Wang NY; Xu Y; Xiao KJ; Zuo WQ; Zhu YX; Hu R; Wang WL; Shi YJ; Yu LT; Liu ZH
Eur J Med Chem; 2020 Apr; 191():112152. PubMed ID: 32088495
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
