158 related articles for article (PubMed ID: 34987222)
1. Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs.
Liang S; Thomas SE; Chaplin AK; Hardwick SW; Chirgadze DY; Blundell TL
Nature; 2022 Jan; 601(7894):643-648. PubMed ID: 34987222
[TBL] [Abstract][Full Text] [Related]
2. Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM.
Hammel M; Rosenberg DJ; Bierma J; Hura GL; Thapar R; Lees-Miller SP; Tainer JA
Prog Biophys Mol Biol; 2021 Aug; 163():74-86. PubMed ID: 32966823
[TBL] [Abstract][Full Text] [Related]
3. Cryo-EM structure of the DNA-PK holoenzyme.
Sharif H; Li Y; Dong Y; Dong L; Wang WL; Mao Y; Wu H
Proc Natl Acad Sci U S A; 2017 Jul; 114(28):7367-7372. PubMed ID: 28652322
[TBL] [Abstract][Full Text] [Related]
4. An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.
Hammel M; Yu Y; Radhakrishnan SK; Chokshi C; Tsai MS; Matsumoto Y; Kuzdovich M; Remesh SG; Fang S; Tomkinson AE; Lees-Miller SP; Tainer JA
J Biol Chem; 2016 Dec; 291(53):26987-27006. PubMed ID: 27875301
[TBL] [Abstract][Full Text] [Related]
5. Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Chen S; Vogt A; Lee L; Naila T; McKeown R; Tomkinson AE; Lees-Miller SP; He Y
Sci Adv; 2023 Jun; 9(22):eadg2838. PubMed ID: 37256947
[TBL] [Abstract][Full Text] [Related]
6. Cryo-EM structure of human DNA-PK holoenzyme.
Yin X; Liu M; Tian Y; Wang J; Xu Y
Cell Res; 2017 Nov; 27(11):1341-1350. PubMed ID: 28840859
[TBL] [Abstract][Full Text] [Related]
7. Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining.
Zhu S; Fisher LA; Bessho T; Peng A
Nucleic Acids Res; 2017 Oct; 45(18):10583-10594. PubMed ID: 28985363
[TBL] [Abstract][Full Text] [Related]
8. Dimers of DNA-PK create a stage for DNA double-strand break repair.
Chaplin AK; Hardwick SW; Liang S; Kefala Stavridi A; Hnizda A; Cooper LR; De Oliveira TM; Chirgadze DY; Blundell TL
Nat Struct Mol Biol; 2021 Jan; 28(1):13-19. PubMed ID: 33077952
[TBL] [Abstract][Full Text] [Related]
9. DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).
Radhakrishnan SK; Lees-Miller SP
DNA Repair (Amst); 2017 Sep; 57():17-28. PubMed ID: 28641126
[TBL] [Abstract][Full Text] [Related]
10. Biochemical evidence for Ku-independent backup pathways of NHEJ.
Wang H; Perrault AR; Takeda Y; Qin W; Wang H; Iliakis G
Nucleic Acids Res; 2003 Sep; 31(18):5377-88. PubMed ID: 12954774
[TBL] [Abstract][Full Text] [Related]
11. X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology.
Hammel M; Tainer JA
Protein Sci; 2021 Sep; 30(9):1735-1756. PubMed ID: 34056803
[TBL] [Abstract][Full Text] [Related]
12. Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA-PKcs in human cells.
Xing M; Oksenych V
FEBS Open Bio; 2019 Jul; 9(7):1315-1326. PubMed ID: 31141305
[TBL] [Abstract][Full Text] [Related]
13. Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks.
Dong J; Zhang T; Ren Y; Wang Z; Ling CC; He F; Li GC; Wang C; Wen B
Oncotarget; 2017 Apr; 8(14):22662-22673. PubMed ID: 28186989
[TBL] [Abstract][Full Text] [Related]
14. A novel small molecule inhibitor of the DNA repair protein Ku70/80.
Weterings E; Gallegos AC; Dominick LN; Cooke LS; Bartels TN; Vagner J; Matsunaga TO; Mahadevan D
DNA Repair (Amst); 2016 Jul; 43():98-106. PubMed ID: 27130816
[TBL] [Abstract][Full Text] [Related]
15. Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways.
Wu Q; Liang S; Ochi T; Chirgadze DY; Huiskonen JT; Blundell TL
Prog Biophys Mol Biol; 2019 Oct; 147():26-32. PubMed ID: 31014919
[TBL] [Abstract][Full Text] [Related]
16. The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation.
Davis AJ; Lee KJ; Chen DJ
J Biol Chem; 2013 Mar; 288(10):7037-46. PubMed ID: 23322783
[TBL] [Abstract][Full Text] [Related]
17. DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.
Sibanda BL; Chirgadze DY; Ascher DB; Blundell TL
Science; 2017 Feb; 355(6324):520-524. PubMed ID: 28154079
[TBL] [Abstract][Full Text] [Related]
18. Multicomponent assemblies in DNA-double-strand break repair by NHEJ.
HnĂzda A; Blundell TL
Curr Opin Struct Biol; 2019 Apr; 55():154-160. PubMed ID: 31125797
[TBL] [Abstract][Full Text] [Related]
19. Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair.
Spagnolo L; Rivera-Calzada A; Pearl LH; Llorca O
Mol Cell; 2006 May; 22(4):511-9. PubMed ID: 16713581
[TBL] [Abstract][Full Text] [Related]
20. Development and Evolution of DNA-Dependent Protein Kinase Inhibitors toward Cancer Therapy.
Matsumoto Y
Int J Mol Sci; 2022 Apr; 23(8):. PubMed ID: 35457081
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]