195 related articles for article (PubMed ID: 35003591)
1. The mechanism of Raf activation through dimerization.
Zhang M; Maloney R; Jang H; Nussinov R
Chem Sci; 2021 Dec; 12(47):15609-15619. PubMed ID: 35003591
[TBL] [Abstract][Full Text] [Related]
2. The mechanism of activation of monomeric B-Raf V600E.
Maloney RC; Zhang M; Jang H; Nussinov R
Comput Struct Biotechnol J; 2021; 19():3349-3363. PubMed ID: 34188782
[TBL] [Abstract][Full Text] [Related]
3. A dimerization-dependent mechanism drives RAF catalytic activation.
Rajakulendran T; Sahmi M; Lefrançois M; Sicheri F; Therrien M
Nature; 2009 Sep; 461(7263):542-5. PubMed ID: 19727074
[TBL] [Abstract][Full Text] [Related]
4. Ras assemblies and signaling at the membrane.
Nussinov R; Tsai CJ; Jang H
Curr Opin Struct Biol; 2020 Jun; 62():140-148. PubMed ID: 32032914
[TBL] [Abstract][Full Text] [Related]
5. Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation.
Jambrina PG; Rauch N; Pilkington R; Rybakova K; Nguyen LK; Kholodenko BN; Buchete NV; Kolch W; Rosta E
Angew Chem Int Ed Engl; 2016 Jan; 55(3):983-6. PubMed ID: 26644280
[TBL] [Abstract][Full Text] [Related]
6. The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation.
Schneider T; Martinez-Martinez A; Cubillos-Rojas M; Bartrons R; Ventura F; Rosa JL
Oncotarget; 2018 Jul; 9(59):31531-31548. PubMed ID: 30140388
[TBL] [Abstract][Full Text] [Related]
7. Phosphorylation of the C-Raf N Region Promotes Raf Dimerization.
Takahashi M; Li Y; Dillon TJ; Kariya Y; Stork PJS
Mol Cell Biol; 2017 Oct; 37(19):. PubMed ID: 28694330
[TBL] [Abstract][Full Text] [Related]
8. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity.
Tzivion G; Luo Z; Avruch J
Nature; 1998 Jul; 394(6688):88-92. PubMed ID: 9665134
[TBL] [Abstract][Full Text] [Related]
9. Analyses of the oncogenic BRAF
Cope NJ; Novak B; Liu Z; Cavallo M; Gunderwala AY; Connolly M; Wang Z
J Biol Chem; 2020 Feb; 295(8):2407-2420. PubMed ID: 31929109
[TBL] [Abstract][Full Text] [Related]
10. Targeting oncogenic Raf protein-serine/threonine kinases in human cancers.
Roskoski R
Pharmacol Res; 2018 Sep; 135():239-258. PubMed ID: 30118796
[TBL] [Abstract][Full Text] [Related]
11. Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis.
Ta L; Tsai BL; Deng W; Sha J; Varuzhanyan G; Tran W; Wohlschlegel JA; Carr-Ascher JR; Witte ON
iScience; 2023 Dec; 26(12):108480. PubMed ID: 38089570
[TBL] [Abstract][Full Text] [Related]
12. RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.
Holderfield M; Merritt H; Chan J; Wallroth M; Tandeske L; Zhai H; Tellew J; Hardy S; Hekmat-Nejad M; Stuart DD; McCormick F; Nagel TE
Cancer Cell; 2013 May; 23(5):594-602. PubMed ID: 23680146
[TBL] [Abstract][Full Text] [Related]
13. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
Brennan DF; Dar AC; Hertz NT; Chao WC; Burlingame AL; Shokat KM; Barford D
Nature; 2011 Apr; 472(7343):366-9. PubMed ID: 21441910
[TBL] [Abstract][Full Text] [Related]
14. The hydrophobic motif of ROCK2 requires association with the N-terminal extension for kinase activity.
Couzens AL; Saridakis V; Scheid MP
Biochem J; 2009 Apr; 419(1):141-8. PubMed ID: 19099536
[TBL] [Abstract][Full Text] [Related]
15. Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway.
Woods D; Cherwinski H; Venetsanakos E; Bhat A; Gysin S; Humbert M; Bray PF; Saylor VL; McMahon M
Mol Cell Biol; 2001 May; 21(9):3192-205. PubMed ID: 11287623
[TBL] [Abstract][Full Text] [Related]
16. A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.
Gárriz A; Qiu H; Dey M; Seo EJ; Dever TE; Hinnebusch AG
Mol Cell Biol; 2009 Mar; 29(6):1592-607. PubMed ID: 19114556
[TBL] [Abstract][Full Text] [Related]
17. Does Ras Activate Raf and PI3K Allosterically?
Nussinov R; Tsai CJ; Jang H
Front Oncol; 2019; 9():1231. PubMed ID: 31799192
[TBL] [Abstract][Full Text] [Related]
18. Fibronectin-induced proliferation in thyroid cells is mediated by alphavbeta3 integrin through Ras/Raf-1/MEK/ERK and calcium/CaMKII signals.
Illario M; Cavallo AL; Monaco S; Di Vito E; Mueller F; Marzano LA; Troncone G; Fenzi G; Rossi G; Vitale M
J Clin Endocrinol Metab; 2005 May; 90(5):2865-73. PubMed ID: 15687337
[TBL] [Abstract][Full Text] [Related]
19. RAF kinase dimerization: implications for drug discovery and clinical outcomes.
Brummer T; McInnes C
Oncogene; 2020 May; 39(21):4155-4169. PubMed ID: 32269299
[TBL] [Abstract][Full Text] [Related]
20. Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.
Freeman AK; Ritt DA; Morrison DK
Mol Cell; 2013 Feb; 49(4):751-8. PubMed ID: 23352452
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
