BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

249 related articles for article (PubMed ID: 35039149)

  • 1. Progranulin as a therapeutic target in neurodegenerative diseases.
    Rhinn H; Tatton N; McCaughey S; Kurnellas M; Rosenthal A
    Trends Pharmacol Sci; 2022 Aug; 43(8):641-652. PubMed ID: 35039149
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
    Huang M; Modeste E; Dammer E; Merino P; Taylor G; Duong DM; Deng Q; Holler CJ; Gearing M; Dickson D; Seyfried NT; Kukar T
    Acta Neuropathol Commun; 2020 Oct; 8(1):163. PubMed ID: 33028409
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
    Arrant AE; Onyilo VC; Unger DE; Roberson ED
    J Neurosci; 2018 Feb; 38(9):2341-2358. PubMed ID: 29378861
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis.
    Root J; Merino P; Nuckols A; Johnson M; Kukar T
    Neurobiol Dis; 2021 Jul; 154():105360. PubMed ID: 33812000
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by
    Holler CJ; Taylor G; Deng Q; Kukar T
    eNeuro; 2017; 4(4):. PubMed ID: 28828399
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
    Arrant AE; Filiano AJ; Patel AR; Hoffmann MQ; Boyle NR; Kashyap SN; Onyilo VC; Young AH; Roberson ED
    Neurobiol Dis; 2019 Apr; 124():152-162. PubMed ID: 30448285
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeting Progranulin as an Immuno-Neurology Therapeutic Approach.
    Boylan MA; Pincetic A; Romano G; Tatton N; Kenkare-Mitra S; Rosenthal A
    Int J Mol Sci; 2023 Nov; 24(21):. PubMed ID: 37958929
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
    Arrant AE; Roth JR; Boyle NR; Kashyap SN; Hoffmann MQ; Murchison CF; Ramos EM; Nana AL; Spina S; Grinberg LT; Miller BL; Seeley WW; Roberson ED
    Acta Neuropathol Commun; 2019 Dec; 7(1):218. PubMed ID: 31870439
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
    Holler CJ; Taylor G; McEachin ZT; Deng Q; Watkins WJ; Hudson K; Easley CA; Hu WT; Hales CM; Rossoll W; Bassell GJ; Kukar T
    Mol Neurodegener; 2016 Jun; 11(1):46. PubMed ID: 27341800
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD.
    Wu Y; Shao W; Todd TW; Tong J; Yue M; Koga S; Castanedes-Casey M; Librero AL; Lee CW; Mackenzie IR; Dickson DW; Zhang YJ; Petrucelli L; Prudencio M
    Cell Rep; 2021 Aug; 36(8):109581. PubMed ID: 34433069
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia.
    Kurnellas M; Mitra A; Schwabe T; Paul R; Arrant AE; Roberson ED; Ward M; Yeh F; Long H; Rosenthal A
    J Transl Med; 2023 Jun; 21(1):387. PubMed ID: 37322482
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Microglial Progranulin: Involvement in Alzheimer's Disease and Neurodegenerative Diseases.
    Mendsaikhan A; Tooyama I; Walker DG
    Cells; 2019 Mar; 8(3):. PubMed ID: 30862089
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
    Ward ME; Chen R; Huang HY; Ludwig C; Telpoukhovskaia M; Taubes A; Boudin H; Minami SS; Reichert M; Albrecht P; Gelfand JM; Cruz-Herranz A; Cordano C; Alavi MV; Leslie S; Seeley WW; Miller BL; Bigio E; Mesulam MM; Bogyo MS; Mackenzie IR; Staropoli JF; Cotman SL; Huang EJ; Gan L; Green AJ
    Sci Transl Med; 2017 Apr; 9(385):. PubMed ID: 28404863
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.
    Amin S; Carling G; Gan L
    Curr Opin Neurobiol; 2022 Feb; 72():131-139. PubMed ID: 34826653
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations.
    Marian OC; Teo JD; Lee JY; Song H; Kwok JB; Landin-Romero R; Halliday G; Don AS
    Acta Neuropathol Commun; 2023 Mar; 11(1):52. PubMed ID: 36967384
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Progranulin as a therapeutic target for dementia.
    Galimberti D; Fenoglio C; Scarpini E
    Expert Opin Ther Targets; 2018 Jul; 22(7):579-585. PubMed ID: 29889573
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
    Zhang T; Feng T; Wu K; Guo J; Nana AL; Yang G; Seeley WW; Hu F
    Acta Neuropathol; 2023 Jul; 146(1):97-119. PubMed ID: 37120788
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia.
    Sung W; Noh MY; Nahm M; Kim YS; Ki CS; Kim YE; Kim HJ; Kim SH
    J Neuroinflammation; 2024 Feb; 21(1):47. PubMed ID: 38347588
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Homozygous GRN mutations: new phenotypes and new insights into pathological and molecular mechanisms.
    Huin V; Barbier M; Bottani A; Lobrinus JA; Clot F; Lamari F; Chat L; Rucheton B; Fluchère F; Auvin S; Myers P; Gelot A; Camuzat A; Caillaud C; Jornéa L; Forlani S; Saracino D; Duyckaerts C; Brice A; Durr A; Le Ber I
    Brain; 2020 Jan; 143(1):303-319. PubMed ID: 31855245
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients.
    Arrant AE; Davis SE; Vollmer RM; Murchison CF; Mobley JA; Nana AL; Spina S; Grinberg LT; Karydas AM; Miller BL; Seeley WW; Roberson ED
    Ann Clin Transl Neurol; 2020 Dec; 7(12):2433-2449. PubMed ID: 33197149
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.