BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

265 related articles for article (PubMed ID: 35065465)

  • 1. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory activity, ulcerogenic liability, ADME profiling and docking study.
    Abdellatif KRA; Abdelall EKA; Elshemy HAH; Philoppes JN; Hassanein EHM; Kahk NM
    Bioorg Chem; 2022 Mar; 120():105627. PubMed ID: 35065465
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies.
    Abdellatif KRA; Abdelall EKA; Elshemy HAH; Philoppes JN; Hassanein EHM; Kahk NM
    Bioorg Chem; 2021 Sep; 114():105122. PubMed ID: 34243075
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE
    Labib MB; Fayez AM; El-Nahass ES; Awadallah M; Halim PA
    Bioorg Chem; 2020 Nov; 104():104308. PubMed ID: 33011534
    [TBL] [Abstract][Full Text] [Related]  

  • 4. New pyridazine derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents; design, synthesis and biological evaluation.
    Ahmed EM; Hassan MSA; El-Malah AA; Kassab AE
    Bioorg Chem; 2020 Jan; 95():103497. PubMed ID: 31838289
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of Hydroxybenzofuranyl-pyrazolyl and Hydroxyphenyl-pyrazolyl Chalcones and Their Corresponding Pyrazoline Derivatives as COX Inhibitors, Anti-inflammatory and Gastroprotective Agents.
    Ragab FAE; Mohammed EI; Abdel Jaleel GA; Selim AAMAE; Nissan YM
    Chem Pharm Bull (Tokyo); 2020; 68(8):742-752. PubMed ID: 32741915
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold.
    Bakr RB; Ghoneim AA; Azouz AA
    Bioorg Chem; 2019 Jul; 88():102964. PubMed ID: 31075742
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.
    Abdellatif KR; Abdelgawad MA; Labib MB; Zidan TH
    Bioorg Med Chem Lett; 2015 Dec; 25(24):5787-91. PubMed ID: 26546221
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of pyridazinone derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents.
    Ahmed EM; Kassab AE; El-Malah AA; Hassan MSA
    Eur J Med Chem; 2019 Jun; 171():25-37. PubMed ID: 30904755
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.
    Abdelgawad MA; Labib MB; Ali WAM; Kamel G; Azouz AA; El-Nahass ES
    Bioorg Chem; 2018 Aug; 78():103-114. PubMed ID: 29550530
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies.
    El-Shoukrofy MS; Abd El Razik HA; AboulWafa OM; Bayad AE; El-Ashmawy IM
    Bioorg Chem; 2019 Apr; 85():541-557. PubMed ID: 30807897
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, anti-inflammatory evaluation and molecular docking of novel thiophen-2-ylmethylene-based derivatives as potential TNF-α production inhibitors.
    Dawood DH; Nossier ES; Abdelhameed MF; Asaad GF; Abd El-Rahman SS
    Bioorg Chem; 2022 May; 122():105726. PubMed ID: 35364361
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and biological evaluation of new nicotinate derivatives as potential anti-inflammatory agents targeting COX-2 enzyme.
    El-Dash Y; Khalil NA; Ahmed EM; Hassan MSA
    Bioorg Chem; 2021 Feb; 107():104610. PubMed ID: 33454504
    [TBL] [Abstract][Full Text] [Related]  

  • 13. New indomethacin analogs as selective COX-2 inhibitors: Synthesis, COX-1/2 inhibitory activity, anti-inflammatory, ulcerogenicity, histopathological, and docking studies.
    Abdellatif KRA; Abdelall EKA; Elshemy HAH; El-Nahass ES; Abdel-Fattah MM; Abdelgawad YYM
    Arch Pharm (Weinheim); 2021 Apr; 354(4):e2000328. PubMed ID: 33314237
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies.
    Fadaly WAA; Elshaier YAMM; Hassanein EHM; Abdellatif KRA
    Bioorg Chem; 2020 May; 98():103752. PubMed ID: 32197148
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2.
    Shaker AMM; Shahin MI; AboulMagd AM; Abdel Aleem SA; Abdel-Rahman HM; Abou El Ella DA
    Bioorg Chem; 2022 Dec; 129():106143. PubMed ID: 36191430
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies.
    Alfayomy AM; Abdel-Aziz SA; Marzouk AA; Shaykoon MSA; Narumi A; Konno H; Abou-Seri SM; Ragab FAF
    Bioorg Chem; 2021 Mar; 108():104555. PubMed ID: 33376011
    [TBL] [Abstract][Full Text] [Related]  

  • 17. COX-1/COX-2 inhibition assays and histopathological study of the new designed anti-inflammatory agent with a pyrazolopyrimidine core.
    Abdelall EKA; Lamie PF; Ahmed AKM; El-Nahass ES
    Bioorg Chem; 2019 May; 86():235-253. PubMed ID: 30716621
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis, molecular docking and anti-inflammatory evaluation of new trisubstituted pyrazoline derivatives bearing benzenesulfonamide moiety.
    Raauf AMR; Omar TN; Mahdi MF; Fadhil HR
    Nat Prod Res; 2024; 38(2):253-260. PubMed ID: 36047992
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.
    Alsayed SS; Elshemy HA; Abdelgawad MA; Abdel-Latif MS; Abdellatif KR
    Bioorg Chem; 2017 Feb; 70():173-183. PubMed ID: 28057325
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel 4- Aryl-2(1H)-phthalazinone Derivatives as Cyclooxygenase-2 Inhibitors: Synthesis, Molecular Modeling Study and Evaluation as Promising Anti-inflammatory Agents.
    Hasabelnaby S; Mohi El-Deen EM; Goudah A
    Antiinflamm Antiallergy Agents Med Chem; 2015; 14(3):148-63. PubMed ID: 26526600
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.