BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

251 related articles for article (PubMed ID: 35075146)

  • 1. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge.
    Mao Z; Xiao H; Shen P; Yang Y; Xue J; Yang Y; Shang Y; Zhang L; Li X; Zhang Y; Du Y; Chen CC; Guo RT; Zhang Y
    Cell Discov; 2022 Jan; 8(1):5. PubMed ID: 35075146
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
    Akkapeddi P; Hattori T; Khan I; Glasser E; Koide A; Ketavarapu G; Whaby M; Zuberi M; Teng KW; Lefler J; Maso L; Bang I; Ostrowski MC; O'Bryan JP; Koide S
    Proc Natl Acad Sci U S A; 2023 Jul; 120(28):e2302485120. PubMed ID: 37399416
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A novel Imidazo[1,2-a]pyridine derivative modulates active KRAS
    Ali Y; Khan AA; Alanazi AM; Fatima S; Kozmon S
    Int J Biol Macromol; 2024 Jun; 270(Pt 2):132477. PubMed ID: 38772459
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS
    Zhou C; Fan Z; Gu Y; Ge Z; Tao Z; Cui R; Li Y; Zhou G; Huo R; Gao M; Wang D; He W; Zheng M; Zhang S; Xu T
    J Med Chem; 2024 Jan; 67(2):1147-1167. PubMed ID: 38197882
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of novel peptide inhibitors for oncogenic KRAS G12D as therapeutic options using mutagenesis-based remodeling and MD simulations.
    Samad A; Khurshid B; Mahmood A; Rehman AU; Khalid A; Abdalla AN; Algarni AS; Wadood A
    J Biomol Struct Dyn; 2023; 41(22):13425-13437. PubMed ID: 37010994
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, Synthesis, and Pharmacological Evaluation of Multisubstituted Pyrido[4,3-
    Xiao X; Feng J; Ma J; Xia X; Liu X; Zhang J; Ding C; Pang X; Zhang A
    J Med Chem; 2023 Nov; 66(22):15524-15549. PubMed ID: 37921024
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRAS
    Issahaku AR; Mukelabai N; Agoni C; Rudrapal M; Aldosari SM; Almalki SG; Khan J
    Sci Rep; 2022 Oct; 12(1):17796. PubMed ID: 36273239
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of Thieno[2,3-d]pyrimidine-based KRAS G12D inhibitors as potential anticancer agents via combinatorial virtual screening.
    Li L; Liu J; Yang Z; Zhao H; Deng B; Ren Y; Mai R; Huang J; Chen J
    Eur J Med Chem; 2022 Apr; 233():114243. PubMed ID: 35276423
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors.
    Nilewski C; Labadie S; Wei B; Malhotra S; Do S; Gazzard L; Liu L; Shao C; Murray J; Izrayelit Y; Gustafson A; Endres NF; Ma F; Ye X; Zou J; Evangelista M
    ACS Med Chem Lett; 2024 Jan; 15(1):21-28. PubMed ID: 38229748
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery.
    Ramalingam PS; Balakrishnan P; Rajendran S; Jothi A; Ramalingam R; Arumugam S
    Curr Issues Mol Biol; 2023 Mar; 45(3):2136-2156. PubMed ID: 36975507
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16.
    Chalabi-Dchar M; Cassant-Sourdy S; Duluc C; Fanjul M; Lulka H; Samain R; Roche C; Breibach F; Delisle MB; Poupot M; Dufresne M; Shimaoka T; Yonehara S; Mathonnet M; Pyronnet S; Bousquet C
    Gastroenterology; 2015 Jun; 148(7):1452-65. PubMed ID: 25683115
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice.
    He P; Yang JW; Yang VW; Bialkowska AB
    Gastroenterology; 2018 Apr; 154(5):1494-1508.e13. PubMed ID: 29248441
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The Therapeutic Landscape for
    Tria SM; Burge ME; Whitehall VLJ
    Cancers (Basel); 2023 Apr; 15(8):. PubMed ID: 37190303
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of potent and noncovalent KRAS
    Wang Y; Zhang H; Li J; Niu MM; Zhou Y; Qu Y
    Front Pharmacol; 2022; 13():1094887. PubMed ID: 36618907
    [TBL] [Abstract][Full Text] [Related]  

  • 15. High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D.
    Sim MJW; Lu J; Spencer M; Hopkins F; Tran E; Rosenberg SA; Long EO; Sun PD
    Proc Natl Acad Sci U S A; 2020 Jun; 117(23):12826-12835. PubMed ID: 32461371
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovering and Targeting Dynamic Drugging Pockets of Oncogenic Proteins: The Role of Magnesium in Conformational Changes of the G12D Mutated Kirsten Rat Sarcoma-Guanosine Diphosphate Complex.
    Hu Z; Marti J
    Int J Mol Sci; 2022 Nov; 23(22):. PubMed ID: 36430338
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery, optimization and biological activity evaluation of genipin derivatives as potential KRAS G12D inhibitors.
    Sun R; Hu Y; Liu X; Lin Y; Lv D; Li W; Fu L; Jiang F
    Bioorg Chem; 2024 Jul; 148():107460. PubMed ID: 38781668
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.
    Young CC; Baker RM; Howlett CJ; Hryciw T; Herman JE; Higgs D; Gibbons R; Crawford H; Brown A; Pin CL
    Cell Mol Gastroenterol Hepatol; 2019; 7(1):93-113. PubMed ID: 30510993
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Multiple Strategies to Develop Small Molecular KRAS Directly Bound Inhibitors.
    Zhou X; Ji Y; Zhou J
    Molecules; 2023 Apr; 28(8):. PubMed ID: 37110848
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antitumor effect of a small-molecule inhibitor of KRAS
    Vázquez-Borrego MC; Granados-Rodríguez M; Bura FI; Martínez-López A; Rufián-Andújar B; Valenzuela-Molina F; Rodríguez-Ortiz L; Haro-Yuste S; Moreno-Serrano A; Ortega-Salas R; Pineda-Reyes R; Michán C; Alhama J; Romero-Ruiz A; Arjona-Sánchez Á
    Exp Hematol Oncol; 2023 Dec; 12(1):102. PubMed ID: 38066554
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.