230 related articles for article (PubMed ID: 35086904)
1. Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.
Tripathi A; Alnakhala H; Terry-Kantor E; Newman A; Liu L; Imberdis T; Fanning S; Nuber S; Ramalingam N; Selkoe D; Dettmer U
J Neurosci; 2022 Mar; 42(10):2116-2130. PubMed ID: 35086904
[TBL] [Abstract][Full Text] [Related]
2. Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Imberdis T; Negri J; Ramalingam N; Terry-Kantor E; Ho GPH; Fanning S; Stirtz G; Kim TE; Levy OA; Young-Pearse TL; Selkoe D; Dettmer U
Proc Natl Acad Sci U S A; 2019 Oct; 116(41):20760-20769. PubMed ID: 31548371
[TBL] [Abstract][Full Text] [Related]
3. Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.
Terry-Kantor E; Tripathi A; Imberdis T; LaVoie ZM; Ho GPH; Selkoe D; Fanning S; Ramalingam N; Dettmer U
Int J Mol Sci; 2020 Jul; 21(15):. PubMed ID: 32707907
[TBL] [Abstract][Full Text] [Related]
4. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Fanning S; Haque A; Imberdis T; Baru V; Barrasa MI; Nuber S; Termine D; Ramalingam N; Ho GPH; Noble T; Sandoe J; Lou Y; Landgraf D; Freyzon Y; Newby G; Soldner F; Terry-Kantor E; Kim TE; Hofbauer HF; Becuwe M; Jaenisch R; Pincus D; Clish CB; Walther TC; Farese RV; Srinivasan S; Welte MA; Kohlwein SD; Dettmer U; Lindquist S; Selkoe D
Mol Cell; 2019 Mar; 73(5):1001-1014.e8. PubMed ID: 30527540
[TBL] [Abstract][Full Text] [Related]
5. A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Nuber S; Nam AY; Rajsombath MM; Cirka H; Hronowski X; Wang J; Hodgetts K; Kalinichenko LS; Müller CP; Lambrecht V; Winkler J; Weihofen A; Imberdis T; Dettmer U; Fanning S; Selkoe DJ
Ann Neurol; 2021 Jan; 89(1):74-90. PubMed ID: 32996158
[TBL] [Abstract][Full Text] [Related]
6. Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes.
Nuber S; Zhang X; McCaffery TD; Moors TE; Adom MA; Hahn WN; Martin D; Ericsson M; Tripathi A; Dettmer U; Svenningsson P; Selkoe DJ
NPJ Parkinsons Dis; 2024 Feb; 10(1):47. PubMed ID: 38424059
[TBL] [Abstract][Full Text] [Related]
7. Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.
Rutherford NJ; Moore BD; Golde TE; Giasson BI
J Neurochem; 2014 Dec; 131(6):859-67. PubMed ID: 24984882
[TBL] [Abstract][Full Text] [Related]
8. Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
Dettmer U; Ramalingam N; von Saucken VE; Kim TE; Newman AJ; Terry-Kantor E; Nuber S; Ericsson M; Fanning S; Bartels T; Lindquist S; Levy OA; Selkoe D
Hum Mol Genet; 2017 Sep; 26(18):3466-3481. PubMed ID: 28911198
[TBL] [Abstract][Full Text] [Related]
9. Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models.
Ramalingam N; Brontesi L; Jin SX; Selkoe DJ; Dettmer U
EMBO Rep; 2023 Dec; 24(12):e57145. PubMed ID: 37870370
[TBL] [Abstract][Full Text] [Related]
10. Oligomers of Parkinson's Disease-Related α-Synuclein Mutants Have Similar Structures but Distinctive Membrane Permeabilization Properties.
Stefanovic AN; Lindhoud S; Semerdzhiev SA; Claessens MM; Subramaniam V
Biochemistry; 2015 May; 54(20):3142-50. PubMed ID: 25909158
[TBL] [Abstract][Full Text] [Related]
11. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity.
Nuber S; Chung CY; Tardiff DF; Bechade PA; McCaffery TD; Shimanaka K; Choi J; Chang B; Raja W; Neves E; Burke C; Jiang X; Xu P; Khurana V; Dettmer U; Fanning S; Rhodes KJ; Selkoe DJ; Scannevin RH
Neurotherapeutics; 2022 Apr; 19(3):1018-1036. PubMed ID: 35445353
[TBL] [Abstract][Full Text] [Related]
12. Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy.
Bodner CR; Maltsev AS; Dobson CM; Bax A
Biochemistry; 2010 Feb; 49(5):862-71. PubMed ID: 20041693
[TBL] [Abstract][Full Text] [Related]
13. Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice.
Rutherford NJ; Dhillon JS; Riffe CJ; Howard JK; Brooks M; Giasson BI
Hum Mol Genet; 2017 Dec; 26(24):4906-4915. PubMed ID: 29036344
[TBL] [Abstract][Full Text] [Related]
14. Library-Derived Peptide Aggregation Modulators of Parkinson's Disease Early-Onset α-Synuclein Variants.
Watt KJC; Meade RM; Williams RJ; Mason JM
ACS Chem Neurosci; 2022 Jun; 13(12):1790-1804. PubMed ID: 35613323
[TBL] [Abstract][Full Text] [Related]
15. Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice.
Rajsombath MM; Nam AY; Ericsson M; Nuber S
J Neurosci; 2019 Sep; 39(38):7628-7640. PubMed ID: 31405930
[TBL] [Abstract][Full Text] [Related]
16. Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants.
Watt KJC; Meade RM; Williams RJ; Mason JM
J Biol Chem; 2022 Dec; 298(12):102565. PubMed ID: 36208776
[TBL] [Abstract][Full Text] [Related]
17. Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction.
Ericsson M; von Saucken V; Newman AJ; Doehr L; Hoesch C; Kim TE; Dettmer U
Brain Res; 2021 May; 1758():147349. PubMed ID: 33571519
[TBL] [Abstract][Full Text] [Related]
18. The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly.
Brontesi L; Imberdis T; Ramalingam N; Dettmer U
J Neurochem; 2023 Apr; 165(2):246-258. PubMed ID: 36625497
[TBL] [Abstract][Full Text] [Related]
19. E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease.
Sakai R; Suzuki M; Ueyama M; Takeuchi T; Minakawa EN; Hayakawa H; Baba K; Mochizuki H; Nagai Y
PLoS One; 2019; 14(6):e0218261. PubMed ID: 31242217
[TBL] [Abstract][Full Text] [Related]
20. SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures.
Nicholatos JW; Groot J; Dhokai S; Tran D; Hrdlicka L; Carlile TM; Bennion M; Dalkilic-Liddle I; Hirst WD; Weihofen A
eNeuro; 2021; 8(4):. PubMed ID: 34301719
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]