These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 35090952)

  • 1. Mechanism of hepatobiliary toxicity of the LPA
    Gill MW; Murphy BJ; Cheng PTW; Sivaraman L; Davis M; Lehman-McKeeman L
    Toxicol Appl Pharmacol; 2022 Mar; 438():115885. PubMed ID: 35090952
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure dependence and species sensitivity of in vivo hepatobiliary toxicity with lysophosphatidic acid receptor 1 (LPA
    Sivaraman L; Gill M; Nelson DM; Chadwick KD
    Toxicol Appl Pharmacol; 2022 Mar; 438():115846. PubMed ID: 34974053
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes.
    Susukida T; Sekine S; Ogimura E; Aoki S; Oizumi K; Horie T; Ito K
    Toxicol In Vitro; 2015 Oct; 29(7):1454-63. PubMed ID: 26055650
    [TBL] [Abstract][Full Text] [Related]  

  • 4. LPA
    Decato BE; Leeming DJ; Sand JMB; Fischer A; Du S; Palmer SM; Karsdal M; Luo Y; Minnich A
    Respir Res; 2022 Mar; 23(1):61. PubMed ID: 35303880
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.
    Lepist EI; Gillies H; Smith W; Hao J; Hubert C; St Claire RL; Brouwer KR; Ray AS
    PLoS One; 2014; 9(1):e87548. PubMed ID: 24498134
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.
    Zhuo X; Howell BA; Shen H; Woodhead JL; Mosure K; Zhang Y; Scialis RJ; Iyer R; Sun Y; Boy KM; Lentz KA; Denton RR; Soars MG; Johnson BM; Humphreys WG
    Toxicol Sci; 2023 Jul; 194(2):235-245. PubMed ID: 37261863
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.
    Feng B; Xu JJ; Bi YA; Mireles R; Davidson R; Duignan DB; Campbell S; Kostrubsky VE; Dunn MC; Smith AR; Wang HF
    Toxicol Sci; 2009 Apr; 108(2):492-500. PubMed ID: 19223659
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Morgan RE; van Staden CJ; Chen Y; Kalyanaraman N; Kalanzi J; Dunn RT; Afshari CA; Hamadeh HK
    Toxicol Sci; 2013 Nov; 136(1):216-41. PubMed ID: 23956101
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis.
    Palmer SM; Snyder L; Todd JL; Soule B; Christian R; Anstrom K; Luo Y; Gagnon R; Rosen G
    Chest; 2018 Nov; 154(5):1061-1069. PubMed ID: 30201408
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition.
    Ryan J; Morgan RE; Chen Y; Volak LP; Dunn RT; Dunn KW
    Drug Metab Dispos; 2018 May; 46(5):704-718. PubMed ID: 29467212
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Establishment of a Drug-Induced, Bile Acid-Dependent Hepatotoxicity Model Using HepaRG Cells.
    Susukida T; Sekine S; Nozaki M; Tokizono M; Oizumi K; Horie T; Ito K
    J Pharm Sci; 2016 Apr; 105(4):1550-60. PubMed ID: 26952880
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.
    Longo DM; Woodhead JL; Walker P; Herédi-Szabó K; Mogyorósi K; Wolenski FS; Dragan YP; Mosedale M; Siler SQ; Watkins PB; Howell BA
    Toxicol Sci; 2019 Feb; 167(2):458-467. PubMed ID: 30289550
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump.
    Rodrigues AD; Lai Y; Cvijic ME; Elkin LL; Zvyaga T; Soars MG
    Drug Metab Dispos; 2014 Apr; 42(4):566-74. PubMed ID: 24115749
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.
    Petrov PD; Fernández-Murga L; Conde I; Martínez-Sena T; Guzmán C; Castell JV; Jover R
    Arch Toxicol; 2020 Feb; 94(2):589-607. PubMed ID: 31894354
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse.
    Zhang J; He K; Cai L; Chen YC; Yang Y; Shi Q; Woolf TF; Ge W; Guo L; Borlak J; Tong W
    Chem Biol Interact; 2016 Aug; 255():45-54. PubMed ID: 27000539
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury.
    Qiu X; Zhang Y; Liu T; Shen H; Xiao Y; Bourner MJ; Pratt JR; Thompson DC; Marathe P; Humphreys WG; Lai Y
    Mol Pharm; 2016 Apr; 13(4):1206-16. PubMed ID: 26910619
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.
    Köck K; Ferslew BC; Netterberg I; Yang K; Urban TJ; Swaan PW; Stewart PW; Brouwer KL
    Drug Metab Dispos; 2014 Apr; 42(4):665-74. PubMed ID: 24154606
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
    Aleo MD; Shah F; He K; Bonin PD; Rodrigues AD
    Chem Res Toxicol; 2017 May; 30(5):1219-1229. PubMed ID: 28437613
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.
    Generaux G; Lakhani VV; Yang Y; Nadanaciva S; Qiu L; Riccardi K; Di L; Howell BA; Siler SQ; Watkins PB; Barton HA; Aleo MD; Shoda LKM
    Pharmacol Res Perspect; 2019 Dec; 7(6):e00523. PubMed ID: 31624633
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing.
    Tátrai P; Erdő F; Krajcsi P
    Pharmaceutics; 2022 Dec; 15(1):. PubMed ID: 36678658
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.