137 related articles for article (PubMed ID: 35114566)
1. The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells.
Palanivel C; Chaudhary N; Seshacharyulu P; Cox JL; Yan Y; Batra SK; Ouellette MM
Neoplasia; 2022 Mar; 25():28-40. PubMed ID: 35114566
[TBL] [Abstract][Full Text] [Related]
2. LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases.
Abe T; Umeki I; Kanno SI; Inoue SI; Niihori T; Aoki Y
Cell Death Differ; 2020 Mar; 27(3):1023-1035. PubMed ID: 31337872
[TBL] [Abstract][Full Text] [Related]
3. Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.
Chen S; Vedula RS; Cuevas-Navarro A; Lu B; Hogg SJ; Wang E; Benbarche S; Knorr K; Kim WJ; Stanley RF; Cho H; Erickson C; Singer M; Cui D; Tittley S; Durham BH; Pavletich TS; Fiala E; Walsh MF; Inoue D; Monette S; Taylor J; Rosen N; McCormick F; Lindsley RC; Castel P; Abdel-Wahab O
Cancer Discov; 2022 Oct; 12(10):2434-2453. PubMed ID: 35904492
[TBL] [Abstract][Full Text] [Related]
4. Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling.
Motta M; Fidan M; Bellacchio E; Pantaleoni F; Schneider-Heieck K; Coppola S; Borck G; Salviati L; Zenker M; Cirstea IC; Tartaglia M
Hum Mol Genet; 2019 Mar; 28(6):1007-1022. PubMed ID: 30481304
[TBL] [Abstract][Full Text] [Related]
5. Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.
Steklov M; Pandolfi S; Baietti MF; Batiuk A; Carai P; Najm P; Zhang M; Jang H; Renzi F; Cai Y; Abbasi Asbagh L; Pastor T; De Troyer M; Simicek M; Radaelli E; Brems H; Legius E; Tavernier J; Gevaert K; Impens F; Messiaen L; Nussinov R; Heymans S; Eyckerman S; Sablina AA
Science; 2018 Dec; 362(6419):1177-1182. PubMed ID: 30442762
[TBL] [Abstract][Full Text] [Related]
6. Ras-AKT signaling represses the phosphorylation of histone H1.5 at threonine 10 via GSK3 to promote the progression of glioma.
Sang B; Sun J; Yang D; Xu Z; Wei Y
Artif Cells Nanomed Biotechnol; 2019 Dec; 47(1):2882-2890. PubMed ID: 31307224
[No Abstract] [Full Text] [Related]
7. Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs.
Cuevas-Navarro A; Rodriguez-Muñoz L; Grego-Bessa J; Cheng A; Rauen KA; Urisman A; McCormick F; Jimenez G; Castel P
Elife; 2022 Apr; 11():. PubMed ID: 35467524
[TBL] [Abstract][Full Text] [Related]
8. GSK-3α promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-κB.
Bang D; Wilson W; Ryan M; Yeh JJ; Baldwin AS
Cancer Discov; 2013 Jun; 3(6):690-703. PubMed ID: 23547054
[TBL] [Abstract][Full Text] [Related]
9. LZTR1 is a regulator of RAS ubiquitination and signaling.
Bigenzahn JW; Collu GM; Kartnig F; Pieraks M; Vladimer GI; Heinz LX; Sedlyarov V; Schischlik F; Fauster A; Rebsamen M; Parapatics K; Blomen VA; Müller AC; Winter GE; Kralovics R; Brummelkamp TR; Mlodzik M; Superti-Furga G
Science; 2018 Dec; 362(6419):1171-1177. PubMed ID: 30442766
[TBL] [Abstract][Full Text] [Related]
10. Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex.
Damianou A; Liang Z; Lassen F; Vendrell I; Vere G; Hester S; Charles PD; Pinto-Fernandez A; Santos A; Fischer R; Kessler BM
Life Sci Alliance; 2024 May; 7(5):. PubMed ID: 38453365
[TBL] [Abstract][Full Text] [Related]
11. Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells.
Marchand B; Arsenault D; Raymond-Fleury A; Boisvert FM; Boucher MJ
J Biol Chem; 2015 Feb; 290(9):5592-605. PubMed ID: 25561726
[TBL] [Abstract][Full Text] [Related]
12. Structural Model for Recruitment of RIT1 to the LZTR1 E3 Ligase: Evidences from an Integrated Computational Approach.
Paladino A; D'Angelo F; Noviello TMR; Iavarone A; Ceccarelli M
J Chem Inf Model; 2021 Apr; 61(4):1875-1888. PubMed ID: 33792302
[TBL] [Abstract][Full Text] [Related]
13. Targeted degradation of KRAS by an engineered ubiquitin ligase suppresses pancreatic cancer cell growth in vitro and in vivo.
Ma Y; Gu Y; Zhang Q; Han Y; Yu S; Lu Z; Chen J
Mol Cancer Ther; 2013 Mar; 12(3):286-94. PubMed ID: 23288781
[TBL] [Abstract][Full Text] [Related]
14. GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4.
Huo X; Liu S; Shao T; Hua H; Kong Q; Wang J; Luo T; Jiang Y
J Biol Chem; 2014 Sep; 289(36):24759-70. PubMed ID: 25053419
[TBL] [Abstract][Full Text] [Related]
15. GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors.
Kazi A; Xiang S; Yang H; Delitto D; Trevino J; Jiang RHY; Ayaz M; Lawrence HR; Kennedy P; Sebti SM
Nat Commun; 2018 Dec; 9(1):5154. PubMed ID: 30514931
[TBL] [Abstract][Full Text] [Related]
16. GSK-3 as a novel prognostic indicator in leukemia.
Ruvolo PP
Adv Biol Regul; 2017 Aug; 65():26-35. PubMed ID: 28499784
[TBL] [Abstract][Full Text] [Related]
17. The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis.
Zhu JY; Li Y; Cao DM; Yang H; Oh E; Bi Y; Zhu S; Wang ZY
Mol Cell; 2017 Jun; 66(5):648-657.e4. PubMed ID: 28575660
[TBL] [Abstract][Full Text] [Related]
18. Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.
Yamamoto GL; Aguena M; Gos M; Hung C; Pilch J; Fahiminiya S; Abramowicz A; Cristian I; Buscarilli M; Naslavsky MS; Malaquias AC; Zatz M; Bodamer O; Majewski J; Jorge AA; Pereira AC; Kim CA; Passos-Bueno MR; Bertola DR
J Med Genet; 2015 Jun; 52(6):413-21. PubMed ID: 25795793
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms.
Marchand B; Tremblay I; Cagnol S; Boucher MJ
Carcinogenesis; 2012 Mar; 33(3):529-37. PubMed ID: 22201186
[TBL] [Abstract][Full Text] [Related]
20. PP2A/B56 and GSK3/Ras suppress PKB activity during Dictyostelium chemotaxis.
Rodriguez Pino M; Castillo B; Kim B; Kim LW
Mol Biol Cell; 2015 Dec; 26(24):4347-57. PubMed ID: 26424797
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
