These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 35143532)

  • 1. p53 oligomerization status as an indicator of sensitivity of p53-wildtype neuroblastomas to the combination of DNA damaging agent and Chk1 inhibitor.
    Levesque AA; Pappalardo RM; Puli P; Enzor LA; Angeles C
    PLoS One; 2022; 17(2):e0263463. PubMed ID: 35143532
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest.
    Levesque AA; Fanous AA; Poh A; Eastman A
    Mol Cancer Ther; 2008 Feb; 7(2):252-62. PubMed ID: 18281511
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.
    Ma CX; Cai S; Li S; Ryan CE; Guo Z; Schaiff WT; Lin L; Hoog J; Goiffon RJ; Prat A; Aft RL; Ellis MJ; Piwnica-Worms H
    J Clin Invest; 2012 Apr; 122(4):1541-52. PubMed ID: 22446188
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
    Eastman A; Kohn EA; Brown MK; Rathman J; Livingstone M; Blank DH; Gribble GW
    Mol Cancer Ther; 2002 Oct; 1(12):1067-78. PubMed ID: 12481430
    [TBL] [Abstract][Full Text] [Related]  

  • 5. p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription.
    Lipski R; Lippincott DJ; Durden BC; Kaplan AR; Keiser HE; Park JH; Levesque AA
    PLoS One; 2012; 7(8):e42615. PubMed ID: 22905155
    [TBL] [Abstract][Full Text] [Related]  

  • 6. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
    Wang Q; Fan S; Eastman A; Worland PJ; Sausville EA; O'Connor PM
    J Natl Cancer Inst; 1996 Jul; 88(14):956-65. PubMed ID: 8667426
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
    Kohn EA; Ruth ND; Brown MK; Livingstone M; Eastman A
    J Biol Chem; 2002 Jul; 277(29):26553-64. PubMed ID: 11953432
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints.
    Levesque AA; Kohn EA; Bresnick E; Eastman A
    Oncogene; 2005 May; 24(23):3786-96. PubMed ID: 15782134
    [TBL] [Abstract][Full Text] [Related]  

  • 9. UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
    Sugiyama K; Shimizu M; Akiyama T; Tamaoki T; Yamaguchi K; Takahashi R; Eastman A; Akinaga S
    Int J Cancer; 2000 Mar; 85(5):703-9. PubMed ID: 10699952
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.
    Tse AN; Schwartz GK
    Cancer Res; 2004 Sep; 64(18):6635-44. PubMed ID: 15374978
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites.
    Montano R; Chung I; Garner KM; Parry D; Eastman A
    Mol Cancer Ther; 2012 Feb; 11(2):427-38. PubMed ID: 22203733
    [TBL] [Abstract][Full Text] [Related]  

  • 12. p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
    Wang XQ; Stanbridge EJ; Lao X; Cai Q; Fan ST; Redpath JL
    Radiat Res; 2007 Dec; 168(6):706-15. PubMed ID: 18088187
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent.
    Nguyen D; Zajac-Kaye M; Rubinstein L; Voeller D; Tomaszewski JE; Kummar S; Chen AP; Pommier Y; Doroshow JH; Yang SX
    Cell Cycle; 2011 Dec; 10(23):4074-82. PubMed ID: 22101337
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells.
    Ando K; Nakamura Y; Nagase H; Nakagawara A; Koshinaga T; Wada S; Makishima M
    Int J Mol Sci; 2019 Jul; 20(15):. PubMed ID: 31362335
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01.
    Redkar A; Mixter P; Daoud SS
    J Exp Ther Oncol; 2004 Oct; 4(3):213-22. PubMed ID: 15724841
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer.
    Ma CX; Ellis MJ; Petroni GR; Guo Z; Cai SR; Ryan CE; Craig Lockhart A; Naughton MJ; Pluard TJ; Brenin CM; Picus J; Creekmore AN; Mwandoro T; Yarde ER; Reed J; Ebbert M; Bernard PS; Watson M; Doyle LA; Dancey J; Piwnica-Worms H; Fracasso PM
    Breast Cancer Res Treat; 2013 Jan; 137(2):483-92. PubMed ID: 23242585
    [TBL] [Abstract][Full Text] [Related]  

  • 17. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
    Yu Q; La Rose J; Zhang H; Takemura H; Kohn KW; Pommier Y
    Cancer Res; 2002 Oct; 62(20):5743-8. PubMed ID: 12384533
    [TBL] [Abstract][Full Text] [Related]  

  • 18. UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines.
    Wu G; Lin N; Xu L; Liu B; Feitelson MA
    BMC Cancer; 2013 Mar; 13():167. PubMed ID: 23537372
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
    Shao RG; Cao CX; Pommier Y
    Acta Pharmacol Sin; 2004 Jun; 25(6):756-62. PubMed ID: 15169628
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
    Shao RG; Cao CX; Shimizu T; O'Connor PM; Kohn KW; Pommier Y
    Cancer Res; 1997 Sep; 57(18):4029-35. PubMed ID: 9307289
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.