These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

170 related articles for article (PubMed ID: 35164077)

  • 1. Spin Trapping Hydroxyl and Aryl Radicals of One-Electron Reduced Anticancer Benzotriazine 1,4-Dioxides.
    Qi W; Yadav P; Hong CR; Stevenson RJ; Hay MP; Anderson RF
    Molecules; 2022 Jan; 27(3):. PubMed ID: 35164077
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Spin trapping of radicals other than the *OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase.
    Shinde SS; Hay MP; Patterson AV; Denny WA; Anderson RF
    J Am Chem Soc; 2009 Oct; 131(40):14220-1. PubMed ID: 19772319
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Shinde SS; Maroz A; Hay MP; Patterson AV; Denny WA; Anderson RF
    J Am Chem Soc; 2010 Mar; 132(8):2591-9. PubMed ID: 20141134
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
    Anderson RF; Shinde SS; Hay MP; Gamage SA; Denny WA
    Org Biomol Chem; 2005 Jun; 3(11):2167-74. PubMed ID: 15917906
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
    Shinde SS; Anderson RF; Hay MP; Gamage SA; Denny WA
    J Am Chem Soc; 2004 Jun; 126(25):7865-74. PubMed ID: 15212534
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides.
    Anderson RF; Yadav P; Shinde SS; Hong CR; Pullen SM; Reynisson J; Wilson WR; Hay MP
    Chem Res Toxicol; 2016 Aug; 29(8):1310-24. PubMed ID: 27380897
    [TBL] [Abstract][Full Text] [Related]  

  • 7. DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.
    Hay MP; Pruijn FB; Gamage SA; Liyanage HD; Kovacs MS; Patterson AV; Wilson WR; Brown JM; Denny WA
    J Med Chem; 2004 Jan; 47(2):475-88. PubMed ID: 14711317
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine.
    Anderson RF; Harris TA; Hay MP; Denny WA
    Chem Res Toxicol; 2003 Nov; 16(11):1477-83. PubMed ID: 14615975
    [TBL] [Abstract][Full Text] [Related]  

  • 9. On the reaction mechanism of tirapazamine reduction chemistry: unimolecular N-OH homolysis, stepwise dehydration, or triazene ring-opening.
    Yin J; Glaser R; Gates KS
    Chem Res Toxicol; 2012 Mar; 25(3):634-45. PubMed ID: 22390168
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria.
    Anderson RF; Shinde SS; Hay MP; Denny WA
    J Am Chem Soc; 2006 Jan; 128(1):245-9. PubMed ID: 16390153
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Spin trapping of lipid radicals with DEPMPO-derived spin traps: detection of superoxide, alkyl and alkoxyl radicals in aqueous and lipid phase.
    Stolze K; Udilova N; Nohl H
    Free Radic Biol Med; 2000 Nov; 29(10):1005-14. PubMed ID: 11084289
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
    Hay MP; Gamage SA; Kovacs MS; Pruijn FB; Anderson RF; Patterson AV; Wilson WR; Brown JM; Denny WA
    J Med Chem; 2003 Jan; 46(1):169-82. PubMed ID: 12502371
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction.
    Anderson RF; Shinde SS; Hay MP; Gamage SA; Denny WA
    J Am Chem Soc; 2003 Jan; 125(3):748-56. PubMed ID: 12526674
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
    Junnotula V; Sarkar U; Sinha S; Gates KS
    J Am Chem Soc; 2009 Jan; 131(3):1015-24. PubMed ID: 19117394
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugs.
    Hunter FW; Wang J; Patel R; Hsu HL; Hickey AJ; Hay MP; Wilson WR
    Biochem Pharmacol; 2012 Mar; 83(5):574-85. PubMed ID: 22182429
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO in the ischemic-reperfused rat liver.
    Culcasi M; Rockenbauer A; Mercier A; Clément JL; Pietri S
    Free Radic Biol Med; 2006 May; 40(9):1524-38. PubMed ID: 16632113
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Electron and spin-density analysis of tirapazamine reduction chemistry.
    Yin J; Glaser R; Gates KS
    Chem Res Toxicol; 2012 Mar; 25(3):620-33. PubMed ID: 22390194
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction.
    Yadav P; Marshall AJ; Reynisson J; Denny WA; Hay MP; Anderson RF
    Chem Commun (Camb); 2014 Nov; 50(89):13729-31. PubMed ID: 25248989
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Trapping of free radicals with direct in vivo EPR detection: a comparison of 5,5-dimethyl-1-pyrroline-N-oxide and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide as spin traps for HO* and SO4*-.
    Timmins GS; Liu KJ; Bechara EJ; Kotake Y; Swartz HM
    Free Radic Biol Med; 1999 Aug; 27(3-4):329-33. PubMed ID: 10468206
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity.
    Guise CP; Abbattista MR; Anderson RF; Li D; Taghipouran R; Tsai A; Lee SJ; Smaill JB; Denny WA; Hay MP; Wilson WR; Hicks KO; Patterson AV
    Molecules; 2020 Oct; 25(21):. PubMed ID: 33105798
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.